Biventricular mechanics in prediction of severe myocardial fibrosis in patients with dilated cardiomyopathy: CMR study

Mazurkiewicz, Łukasz; Petryka, Joanna; Śpiewak, Mateusz; Miłosz-Wieczorek, Barbara; Werys, Konrad; Małek, Łukasz A.; Polańska-Skrzypczyk, Magdalena; Ojrzyńska, Natalia; Kubik, Agata; Marczak, Magdalena; Miśko, Jolanta; Grzybowski, Jacek

doi:10.1016/j.ejrad.2017.03.019

Cited by 10 publications

(8 citation statements)

References 27 publications

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“…We did not observe any link between hs-TnT and replacement fibrosis (i.e., LGE extent), which is in agreement with previous research from Yi et al [47]. However, we detected a strong association (HR 8.3) between hs-TnT and interstitial fibrosis (i.e., ECV), which is similar to the observations of Mazurkiewicz et al, who also revealed a link between hs-TnT and ECV in DCM [46].…”

Section: Associations Between Bnp and Hs-tnt Withsupporting

confidence: 92%

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Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

Rubiś

Dziewięcka

Szymańska

et al. 2021

Cells

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The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center, observational study. The study population was composed of 100 DCM patients (87 male, mean age 45.2 ± 11.8 years, mean ejection fraction 29.7% ± 10.1%). Replacement fibrosis was quantified by means of late gadolinium enhancement (LGE), whereas interstitial fibrosis was assessed via extracellular volume (ECV). Plasma concentrations of cardiotrophin-1, growth differentiation factor-15, platelet-derived growth factor, procollagen I C-terminal propeptide, procollagen III N-terminal propeptide, and C-terminal telopeptide of type I collagen were measured. There were 44% patients with LGE and the median ECV was 27.7%. None of analyzed fibrosis serum biomarkers were associated with the LGE or ECV, whereas NT-proBNP was independently associated with both LGE and ECV, and troponin T was associated with ECV. None of the circulating fibrosis markers differentiated between DCM patients with and without replacement fibrosis, or patients stratified according to median ECV. However, cardiac-specific markers, such as NT-proBNP and hs-TnT, were associated with fibrosis. Levels of circulating markers of fibrosis seem to have no utility in the diagnosis and monitoring of cardiac fibrosis in DCM.

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Section: Associations Between Bnp and Hs-tnt Withsupporting

confidence: 92%

“…Similarly, Tachi et al and Child et al reported correlations between post-contrast T1 times and BNP in DCM [ 44 , 45 ]. In the same vein, Child et al and Mazurkiewicz et al showed associations between ECV and NT-proBNP [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

Rubiś

Dziewięcka

Szymańska

et al. 2021

Cells

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“…It must also be noted that CMR mapping techniques were not applied to our cohort, whereas they are now considered important in the diagnosis of PPCM. Our results may suggest the use of biventricular strain parameters for predicting fibrosis severity in PPCM [14]. However, due to the small sample size, we did not assess any association between strain values and outcomes.…”

Section: Study Limitationsmentioning

confidence: 75%

“…SSFP images were used to calculate left (LV) and right ventricular (RV) volumes and ejection fractions (EF) with the use of dedicated software (Syngo via. Siemens, Erlangen, Germany), as previously described [14]. Left atrial (LA) and right atrial (RA) volumetric and functional calculations were performed separately by two independent and skilled observers (JPM and LM) according to a previously described protocol [15].…”

Section: Image Analysismentioning

confidence: 99%

Cardiovascular Magnetic Resonance in Peripartum Cardiomyopathy: Comparison with Idiopathic Dilated Cardiomyopathy

et al. 2021

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Background: Peripartum (PPCM) and dilated (DCM) cardiomyopathies are distinct forms of cardiac disease that share certain aspects in clinical presentation. Aim: We hypothesized that different cardiac structural changes underlie PPCM and DCM, and we aimed to investigate them with cardiovascular magnetic resonance (CMR). Methods: We included 21 PPCM patients (30.5 ± 5.9 years) and 30 female DCM patients (41.5 ± 16.8 years) matched for left ventricular ejection fraction. Biventricular and biatrial volumetric and functional parameters were assessed along with ventricular and atrial strain indices based on feature-tracking techniques. The presence of late gadolinium enhancement (LGE) was also assessed. Results: In PPCM, the left ventricular (LV) stroke volume index was lower (p = 0.04), right atrial (RA) minimal and pre-systolic volumes were higher (p < 0.01 and p = 0.02, respectively), and the total RA ejection fraction was lower (p = 0.02) in comparison to DCM. Moreover, in PPCM, the LV global longitudinal strain (p = 0.03), global circumferential strain rate (p = 0.04), and global longitudinal strain rate (p < 0.01) were less impaired than in DCM. Both PPCM and DCM patients with LGE had more dilated ventricles and more impaired LV and left atrial function than in PPCM and DCM patients without LGE. Conclusions: Subtle differences appear on CMR between PPCM and DCM. Most importantly, the RA is larger and more impaired, and LV global longitudinal strain is less reduced in PPCM than in DCM. Furthermore, similarly to DCM, PPCM patients with LGE have more dilated and impaired ventricles than patients without LGE.

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“…Recent approaches including strain assessment even enabled distinguishing between DCM patients and physiological exercise-induced cardiac remodeling by applying CMR stress protocols [60]. Furthermore, CMR strain assessment by measuring low LV contractile reverses under dobutamine stress enabled prediction of biventricular fibrosis [61] and myocardial remodelling in patients with DCM, which was associated with a lower probability of functional recovery [62]. Importantly, biventricular dysfunction and a significant prognostic impact of RV GLS in patients with advanced staged DCM have been demonstrated beyond LV performance quantification [63].…”

Section: Cmr-ft In Non-ischemic Cardiomyopathiesmentioning

confidence: 99%

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

Lange

Schuster

2021

Curr Heart Fail Rep

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Purpose of Review Cardiac magnetic resonance-feature-tracking (CMR-FT)-based deformation analyses are key tools of cardiovascular imaging and applications in heart failure (HF) diagnostics are expanding. In this review, we outline the current range of application with diagnostic and prognostic implications and provide perspectives on future trends of this technique. Recent Findings By applying CMR-FT in different cardiovascular diseases, increasing evidence proves CMR-FT-derived parameters as powerful diagnostic and prognostic imaging biomarkers within the HF continuum partly outperforming traditional clinical values like left ventricular ejection fraction. Importantly, HF diagnostics and deformation analyses by CMR-FT are feasible far beyond sole left ventricular performance evaluation underlining the holistic nature and accuracy of this imaging approach. Summary As an established and continuously evolving technique with strong prognostic implications, CMR-FT deformation analyses enable comprehensive cardiac performance quantification of all cardiac chambers.

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Biventricular mechanics in prediction of severe myocardial fibrosis in patients with dilated cardiomyopathy: CMR study

Cited by 10 publications

References 27 publications

Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

Cardiovascular Magnetic Resonance in Peripartum Cardiomyopathy: Comparison with Idiopathic Dilated Cardiomyopathy

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking—All About the Left Ventricle?

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