2021
DOI: 10.3390/cells10061295
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Lack of Relationship between Fibrosis-Related Biomarkers and Cardiac Magnetic Resonance-Assessed Replacement and Interstitial Fibrosis in Dilated Cardiomyopathy

Abstract: The relationship between circulating fibrosis-related molecules and magnetic resonance-assessed cardiac fibrosis in dilated cardiomyopathy (DCM) is poorly understood. To compare circulating biomarkers between DCM patients with high and low fibrosis burdens, we performed a prospective, single-center, observational study. The study population was composed of 100 DCM patients (87 male, mean age 45.2 ± 11.8 years, mean ejection fraction 29.7% ± 10.1%). Replacement fibrosis was quantified by means of late gadoliniu… Show more

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Cited by 4 publications
(2 citation statements)
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“…Poulsen et al showed that hypertensive patients had decreased longitudinal strain and increased amino-terminal propeptide of procollagen type III, accompanied by an inverse correlation of the two parameters [20]. Plasma markers emerge in an early stage of a myocardial fibrotic process in mild to moderate hypertensive patients and indirectly reflect myocardial fibrosis, and may lack specificity in the case of concomitant fibrotic diseases (e.g., cardiac fibrosis combined with liver or kidney fibrosis) [33]. However, the patients in the current study rather suffered a late fibrotic process due to LGE-CMR is a visual approach to directly display focal myocardial fibrosis [34].…”
Section: Differences In Strain Between Lge + and Lge − Rh Patientsmentioning
confidence: 99%
“…Poulsen et al showed that hypertensive patients had decreased longitudinal strain and increased amino-terminal propeptide of procollagen type III, accompanied by an inverse correlation of the two parameters [20]. Plasma markers emerge in an early stage of a myocardial fibrotic process in mild to moderate hypertensive patients and indirectly reflect myocardial fibrosis, and may lack specificity in the case of concomitant fibrotic diseases (e.g., cardiac fibrosis combined with liver or kidney fibrosis) [33]. However, the patients in the current study rather suffered a late fibrotic process due to LGE-CMR is a visual approach to directly display focal myocardial fibrosis [34].…”
Section: Differences In Strain Between Lge + and Lge − Rh Patientsmentioning
confidence: 99%
“…On the other hand, these collagen-derived biomarkers are not cardiac specific, and they are sensitive to comorbidities and noncardiac conditions that affect collagen turnover. Extensive validation is still needed because accumulating studies have indicated the circulating level of these biomarkers (e.g., PICP and PIIINP) did not correlate with the collagen content derived from histological examination or imaging techniques ( 29 31 ). Hence, these biomarkers have not yet been implemented in clinical practice.…”
Section: Detection: Laboratory Biomarkers and Imaging Techniquesmentioning
confidence: 99%