Bithorax Complex genes control alary muscle patterning along the cardiac tube of Drosophila

LaBeau, Elisa M.; Trujillo, Damian L.; Cripps, Richard M.

doi:10.1016/j.mod.2009.01.001

Cited by 28 publications

(39 citation statements)

References 29 publications

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“…Interestingly, pan-mesodermal expression of either Ubx or AbdA, two abdominal Hox proteins, resulted in the formation of three supernumerary pairs of AMs arranged in a segmental pattern in the three thoracic segments (LaBeau et al, 2009). This suggested the existence of thoracic PCs that fail to give rise to muscles in the absence of proper Hox input.…”

Section: Ams and Tarms: Homologous Muscle Lineages With Morphologies mentioning

confidence: 99%

An Org-1–Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila

et al. 2014

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The T-box transcription factor Tbx1 and the LIM-homeodomain transcription factor Islet1 are key components in regulatory circuits that generate myogenic and cardiogenic lineage diversity in chordates. We show here that Org-1 and Tup, the Drosophila orthologs of Tbx1 and Islet1, are co-expressed and required for formation of the heart-associated alary muscles (AMs) in the abdomen. The same holds true for lineage-related muscles in the thorax that have not been described previously, which we name thoracic alary-related muscles (TARMs). Lineage analyses identified the progenitor cell for each AM and TARM. Three-dimensional highresolution analyses indicate that AMs and TARMs connect the exoskeleton to the aorta/heart and to different regions of the midgut, respectively, and surround-specific tracheal branches, pointing to an architectural role in the internal anatomy of the larva. Org-1 controls tup expression in the AM/TARM lineage by direct binding to two regulatory sites within an AM/TARM-specific cis-regulatory module, tupAME. The contributions of Org-1 and Tup to the specification of Drosophila AMs and TARMs provide new insights into the transcriptional control of Drosophila larval muscle diversification and highlight new parallels with gene regulatory networks involved in the specification of cardiopharyngeal mesodermal derivatives in chordates.

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Section: Ams and Tarms: Homologous Muscle Lineages With Morphologies mentioning

confidence: 99%

An Org-1–Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila

et al. 2014

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“…The somatic musculature of the Drosophila embryo is a classical model with which to study the regulatory processes that generate cellular diversity in response to positional information provided by embryonic body axes. Each hemi-segment shows a stereotypical arrangement of 30 somatic muscles connected to the exoskeleton, one alary muscle that attaches to the dorsal vessel, which is the equivalent of the heart, and six muscle stem-like cells [known as adult muscle precursors (AMPs)] Bate et al, 1991;Figeac et al, 2010;LaBeau et al, 2009). Each skeletal muscle is a syncytium seeded by a founder cell (FC), which undergoes multiple rounds of fusion with fusion-competent myoblasts.…”

Section: Introductionmentioning

confidence: 99%

Tup/Islet1 integrates time and position to specify muscle identity in Drosophila

et al. 2012

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SUMMARYThe LIM-homeodomain transcription factor Tailup/Islet1 (Tup) is a key component of cardiogenesis in Drosophila and vertebrates. We report here an additional major role for Drosophila Tup in specifying dorsal muscles. Tup is expressed in the four dorsal muscle progenitors (PCs) and tup-null embryos display a severely disorganized dorsal musculature, including a transformation of the dorsal DA2 into dorsolateral DA3 muscle. This transformation is reciprocal to the DA3 to DA2 transformation observed in collier (col) mutants. The DA2 PC, which gives rise to the DA2 muscle and to an adult muscle precursor, is selected from a cluster of myoblasts transiently expressing both Tinman (Tin) and Col. The activation of tup by Tin in the DA2 PC is required to repress col transcription and establish DA2 identity. The transient, partial overlap between Tin and Col expression provides a window of opportunity to distinguish between DA2 and DA3 muscle identities. The function of Tup in the DA2 PC illustrates how single cell precision can be reached in cell specification when temporal dynamics are combined with positional information. The contributions of Tin, Tup and Col to patterning Drosophila dorsal muscles bring novel parallels with chordate pharyngeal muscle development.

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“…Although we did not quantify the phenotype, we observed that the number of projections varied. For example, we saw additional Prc-positive projections at positions different from where the seven pairs of alary muscles normally attach (LaBeau et al, 2009). Not much is known about the embryonic origin of the alary muscles and the molecules required for their development.…”

Section: Discussionmentioning

confidence: 94%

A role for Drosophila Wnt‐4 in heart development

Tauc¹,

Mann²,

Werner³

et al. 2012

Genesis

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Summary:In vertebrates, different Wnt-signaling pathways are required in a temporally coordinated manner to promote cardiogenesis. In Drosophila, wingless holds an essential role in heart development. Among the known Drosophila Wnts is DWnt4, the function of which has been studied in various developmental processes except for heart development. We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm. Moreover, we detect DWnt4 mRNA transcripts in myocardial cells by stage 16. The heart phenotype in DWnt4 mutant embryos is characterized by various degrees of disrupted expression of different cardiac markers. Overexpression of Dwnt4 also affects heart marker expression, which can be partially rescued by simultaneous inhibition of PKC. Our data reveal a role for DWnt4 in cardiogenesis; however, integration of DWnt4 with other known signaling pathways that function in heart development still awaits further investigation. genesis 50:466-481 , 2012. V V C 2012 Wiley Periodicals, Inc.

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Bithorax Complex genes control alary muscle patterning along the cardiac tube of Drosophila

Cited by 28 publications

References 29 publications

An Org-1–Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila

An Org-1–Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila

Tup/Islet1 integrates time and position to specify muscle identity in Drosophila

A role for Drosophila Wnt‐4 in heart development

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