Bisphenols impact hormone levels in animals: A meta-analysis

Rubin, Alexander M.; Seebacher, Frank

doi:10.1016/j.scitotenv.2022.154533

Cited by 25 publications

(8 citation statements)

References 74 publications

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“…Thus, it can affect steroidogenic enzyme expression and interfere with sex steroid levels [ 11 ]. Numerous animal studies have demonstrated that exposure to BPA has adverse reproductive and behavioral outcomes [ 12 – 14 ]. Similarly, emerging human researches suggest that BPA has unfavorable impacts on the reproductive system of both sexes, metabolic processes, like obesity and diabetes, and cardiovascular diseases [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, BPF and BPS have also been identified with estrogenic and anti-androgenic features because these analogs have similar chemical structures to BPA [ 20 ]. Additionally, as per in vitro and in vivo studies, they cause similar endocrine alterations and adverse physiological effects [ 14 , 21 , 22 ]. Recently, Wang et al focused on associations of urinary bisphenol concentrations with adverse effects on sex hormones in children and adolescents, revealing that BPA analogs (BPS and BPF) could have comparable endocrine disrupting effects as those possessed by BPA [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

et al. 2022

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Background Bisphenol A (BPA) exposure and its structural analogs (BPS and BPF) might cause endocrine alterations and adverse physiological effects. Few studies to date have directly explored the association between its structural analogs (BPS, BPF) and sex hormones in adult male participants. Therefore, we aimed to assess the associations between BPA, BPS, BPF, and sex hormones in American adult men. Methods We used data from the U.S. National Health and Nutrition Examination Survey 2011–2016. We excluded participants without data available on sex hormones and urinary bisphenols. Furthermore, participants consuming sex hormone medications were excluded. Multivariable regression models were performed to assess the association between bisphenols and sex hormones. Results In this study, 2367 participants were included. Of 2367, in 1575 participants, the data on BPS and BPF were available. We found that a per unit increase in BPF was associated with 0.575 ng/dL higher total testosterone (TT) (Model 2: 95% CI: 0.047, 1.103, P = 0.033). However, there was no significant association between BPA or BPS and TT. Furthermore, increased BPA and BPS levels were associated with higher levels of sex hormone-binding globulin (SHBG) (Model 2: β = 0.364, 95% CI: 0.158, 0.571; β = 0.25, 95% CI: 0.071, 0.429, respectively). Additionally, participants in the highest BPA exposure quartile (quartile 4) had 4.072 nmol/L higher levels of SHBG than those in quartile 1 (Model 2: 95% CI: 0.746, 7.397, P = 0.017; P for trend =0.005). Both BPA and BPS were negatively associated with free testosterone (FT, nmol/L) after full adjustment (Model 2, β = − 0.01%, P = 0.0211, P = 0.0211; Model 2, β = − 0.01%, P = 0.0258, respectively). However, BPF was positively associated with FT (Model 2, β = 0.0029%, P = 0.0028). Conclusion Our study indicated that exposure to both BPA and its substitutions could alter sex hormone levels. This finding supports the possibility that human exposure to bisphenols at environmental levels might affect the endogenous hormone balance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

et al. 2022

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“…A vast range of human-manufactured chemicals are now present in the environment and many disrupt endocrine function [104][105][106]. The thyroid axis is particularly susceptible to chemical endocrine disruption by industrial chemicals that are commonly found in the environment globally, including bisphenols, halogenated organochlorides and polychlorinated biphenyls [8,107,108]. EDCs can disrupt nearly all steps in the thyroid signalling cascade from thyroid production and transport to disruption of deiodinase enzymes and thyroid receptors [8,[109][110][111].…”

Section: (B) Anthropogenic Impacts: Compounded Perturbationsmentioning

confidence: 99%

Thyroid hormone links environmental signals to DNA methylation

Seebacher,

Little

2024

Phil. Trans. R. Soc. B

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Environmental conditions experienced within and across generations can impact individual phenotypes via so-called ‘epigenetic' processes. Here we suggest that endocrine signalling acts as a ‘sensor' linking environmental inputs to epigenetic modifications. We focus on thyroid hormone signalling and DNA methylation, but other mechanisms are likely to act in a similar manner. DNA methylation is one of the most important epigenetic mechanisms, which alters gene expression patterns by methylating cytosine bases via DNA methyltransferase enzymes. Thyroid hormone is mechanistically linked to DNA methylation, at least partly by regulating the activity of DNA methyltransferase 3a, which is the principal enzyme that mediates epigenetic responses to environmental change. Thyroid signalling is sensitive to natural and anthropogenic environmental impacts (e.g. light, temperature, endocrine-disrupting pollution), and here we propose that thyroid hormone acts as an environmental sensor to mediate epigenetic modifications. The nexus between thyroid hormone signalling and DNA methylation can integrate multiple environmental signals to modify phenotypes, and coordinate phenotypic plasticity at different time scales, such as within and across generations. These dynamics can have wide-ranging effects on health and fitness of animals, because they influence the time course of phenotypic adjustments and potentially the range of environmental stimuli that can elicit epigenetic responses. This article is part of the theme issue ‘Endocrine responses to environmental variation: conceptual approaches and recent developments’.

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“…Human exposure to bisphenols present in the environment most commonly occurs through food intake, followed by inhalation and direct skin contact with environmental components such as indoor dust, soil, and surface water [ 80 , 81 ]. Bisphenols ingested through food intake are mainly derived from plastic packaging and containers.…”

Section: Contamination Status Of Bisphenolsmentioning

confidence: 99%

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

Wu,

Tian,

Zhu

et al. 2023

Toxics

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Reproductive disorders are considered a global health problem influenced by physiological, genetic, environmental, and lifestyle factors. The increased exposure to bisphenols, a chemical used in large quantities for the production of polycarbonate plastics, has raised concerns regarding health risks in humans, particularly their endocrine-disrupting effects on female reproductive health. To provide a basis for future research on environmental interference and reproductive health, we reviewed relevant studies on the exposure patterns and levels of bisphenols in environmental matrices and humans (including susceptible populations such as pregnant women and children). In addition, we focused on in vivo, in vitro, and epidemiological studies evaluating the effects of bisphenols on the female reproductive system (the uterus, ovaries, fallopian tubes, and vagina). The results indicate that bisphenols cause structural and functional damage to the female reproductive system by interfering with hormones; activating receptors; inducing oxidative stress, DNA damage, and carcinogenesis; and triggering epigenetic changes, with the damaging effects being intergenerational. Epidemiological studies support the association between bisphenols and diseases such as cancer of the female reproductive system, reproductive dysfunction, and miscarriage, which may negatively affect the establishment and maintenance of pregnancy. Altogether, this review provides a reference for assessing the adverse effects of bisphenols on female reproductive health.

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Bisphenols impact hormone levels in animals: A meta-analysis

Cited by 25 publications

References 74 publications

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males

Thyroid hormone links environmental signals to DNA methylation

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives

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