Bisphenol S promotes fat storage in multiple generations of Caenorhabditis elegans in a daf-16/nhr-49 dependent manner

Zhou, Xinghua; Li, Jie; Zhang, Xiaowei; Zhang, Caiqin; Bai, Juan; Zhao, Yansheng; Zhu, Ying; Zhang, Jiayan; Xiao, Xiang

doi:10.1016/j.cbpc.2021.109175

Cited by 9 publications

(4 citation statements)

References 27 publications

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“…Starvation or stress of F0 C. elegans elicited altered metabolism on the F3 generation [52,53]. Multigenerational exposure to bisphenol S (BPS) in C.elegans promoted fat storage over four generations [54]. Long-term, high dose exposure of F0 Drosophila melanogaster to DEHP led to an increased bodyweight of the offspring [55].…”

Section: Transgenerational Inheritance Of Obesitymentioning

confidence: 99%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

100

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Section: Transgenerational Inheritance Of Obesitymentioning

confidence: 99%

Obesity II: Establishing causal links between chemical exposures and obesity

Heindel¹,

Howard²,

Agay-Shay³

et al. 2022

Biochemical Pharmacology

100

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“…TBT: [182] Bisphenols: [186] C. elegans Obesity phenotype Increased weight, adiposity, and/or lipid accumulation Bisphenols: [199], [285] Erythromycin: [198] PFOA: [286] NAFLD phenotype Steatosis, fatty liver Metabolism changes Metabolomics, lipids, fatty acids, diabetic phenotype, etc.…”

Section: Speciesmentioning

confidence: 99%

Obesity III: Obesogen assays: Limitations, strengths, and new directions

Kassotis

Saal

Babin

et al. 2022

Biochemical Pharmacology

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“…Hence, the upregulation of these two genes can be used as a sign of enhanced fatty acid β oxidation. In addition, the overexpression of the acs-2 gene can push Caenorhabditis elegans into a low-fat state [ 41 ], which further indicates that it is a key target gene in A. muciniphila cell-free supernatant to regulate lipid metabolism. Previous studies have shown that some natural products can reduce the total fat content of C. elegans by upregulating the acs-2 gene [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Akkermansia muciniphila Cell-Free Supernatant Improves Glucose and Lipid Metabolisms in Caenorhabditis elegans

Chen

et al. 2023

Nutrients

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To explore the mechanism by which Akkermansia muciniphila cell-free supernatant improves glucose and lipid metabolisms in Caenorhabditis elegans, the present study used different dilution concentrations of Akkermansia muciniphila cell-free supernatant as an intervention for with Caenorhabditis elegans under a high-glucose diet. The changes in lifespan, exercise ability, level of free radicals, and characteristic indexes of glucose and lipid metabolisms were studied. Furthermore, the expression of key genes of glucose and lipid metabolisms was detected by qRT-PCR. The results showed that A. muciniphila cell-free supernatant significantly improved the movement ability, prolonged the lifespan, reduced the level of ROS, and alleviated oxidative damage in Caenorhabditis elegans. A. muciniphila cell-free supernatant supported resistance to increases in glucose and triglyceride induced by a high-glucose diet and downregulated the expression of key genes of glucose metabolism, such as gsy-1, pygl-1, pfk-1.1, and pyk-1, while upregulating the expression of key genes of lipid metabolism, such as acs-2, cpt-4, sbp-1, and tph-1, as well as down-regulating the expression of the fat-7 gene to inhibit fatty acid biosynthesis. These findings indicated that A. muciniphila cell-free supernatant, as a postbiotic, has the potential to prevent obesity and improve glucose metabolism disorders and other diseases.

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Bisphenol S promotes fat storage in multiple generations of Caenorhabditis elegans in a daf-16/nhr-49 dependent manner

Cited by 9 publications

References 27 publications

Obesity II: Establishing causal links between chemical exposures and obesity

Obesity II: Establishing causal links between chemical exposures and obesity

Obesity III: Obesogen assays: Limitations, strengths, and new directions

Akkermansia muciniphila Cell-Free Supernatant Improves Glucose and Lipid Metabolisms in Caenorhabditis elegans

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