Bisphenol S leads to cytotoxicity-induced antioxidant responses and oxidative stress in isolated rainbow trout (Oncorhyncus mykiss) hepatocytes

Kaptaner, Burak; Yılmaz, Can; Aykut, Handan; Doğan, Emine; Fidan, Ceylan; Bostancı, Müşerref; Yıldız, Fatoş

doi:10.1007/s11033-021-06771-6

Cited by 16 publications

(8 citation statements)

References 59 publications

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“…8-OHdG is an important biological indicator of oxidative damage, and BPS increases intracellular ROS level and lipid peroxidation via hyperuricaemia, depletes antioxidant enzyme activity including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST) and GSTT1 and reduces glutathione (GSH) content, thereby inducing oxidative damage. 30 In contrast, allopurinol demonstrated recovery from BPS toxicity in the current study. Allopurinol delays the progression of renal damage and restores normal glomerular and tubular architecture by decreasing UA through the inhibition of xanthine oxidase and ROS production via its antioxidant effect.…”

Section: Discussioncontrasting

confidence: 58%

“…Similar to the findings of Wang et al, 29 8‐OHdG levels were elevated with BPS in the present study. 8‐OHdG is an important biological indicator of oxidative damage, and BPS increases intracellular ROS level and lipid peroxidation via hyperuricaemia, depletes antioxidant enzyme activity including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S‐transferase (GST) and GSTT1 and reduces glutathione (GSH) content, thereby inducing oxidative damage 30 …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Khalifa

Hosny

Matter

et al. 2022

Basic Clin Pharma Tox

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Bisphenol S (BPS) is used as an alternative to bisphenol A (BPA) in polycarbonate plastics, epoxy resins and thermal receipt sheet manufacturing. We examined the toxic effects of BPS on gastric and renal functions, as well as the efficacy of allopurinol as a treatment. Albino rats were given only BPS (30 and 120 mg/kg BW/day), and some were treated with allopurinol prior to sacrifice. Gastric and renal specimens were evaluated histologically and immunohistochemically, and blood from the tail vein was analysed for levels of gastrin, uric acid (UA), erythropoietin and 8‐deoxyguanosine (8‐OHdG). Gastrin levels decreased while erythropoietin, UA and 8‐OHdG levels increased significantly. The severity of gastric and renal damage observed in BPS‐treated animals increased with increasing doses. The mean percentage of COX‐2 immunoreactivity and the mean number of CD45 immunoreactive cells were significantly increased in the stomach and kidney of BPS rats. Allopurinol ameliorated the biochemical, histological and immunohistochemical alterations induced by BPS, with superior protection at lower doses. Allopurinol can reverse the effects of BPS on the stomach and kidneys.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Khalifa

Hosny

Matter

et al. 2022

Basic Clin Pharma Tox

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“…[66] Contrary to our observations regarding GST activity, researchers have established that GST activity significantly increases on exposure to 31.25 µM or high concentrations of BPS, whereas GST Theta 1-1 activity is reduced by a similar amount of BPS. [61] Interestingly, in our investigation, an increase in GPx activity was recorded only when the fish were exposed to 12 ppm of BPS for 21 days. The increased GPx activity may be attributed to the elevated levels of hydrogen peroxide and lipid peroxide.…”

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Biochemical responses and antioxidant defense mechanisms in Channa Striatus exposed to Bisphenol S

Mohan,

Jacob,

Malini

et al. 2024

J Biochem & Molecular Tox

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Bisphenol S (BPS), a BPA analog and a safer alternative, is utilized in a diverse range of industrial applications, such as making polycarbonate plastics, epoxy resins, thermal receipt papers, and currency bills. Recently, the increased use of BPS in containers and packages for daily life has been interrogated due to its identical chemical structure and probable endocrine‐disrupting actions as BPA has. The present study aimed to evaluate the alterations in biochemical indices and antioxidant enzymes as certain indicators of the endocrine‐disrupting effect of BPS in Channa striatus, a freshwater fish. BPS‐exposed fish species were subjected to three sub‐lethal concentrations of BPS (1, 4, and 12 ppm) and observed after an interval of 7 and 21 days. Exposure to BPS caused a reduction in the level of protein in muscle, gonads and the liver due to an impairment of protein synthesis. Levels of cholesterol in the muscle, gonads, and liver of BPS‐exposed fish were found to be decreased after treatment, indicating either an inhibition of cholesterol biosynthesis in the liver or reduced absorption of dietary cholesterol. The levels of antioxidant enzymes such as superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase showed remarkable increases, while the activity of glutathione S‐transferase decreased considerably, indicating the antioxidant defense mechanism to counteract the oxidative stress induced by BPS. Moreover, a significant increase was noted in the level of lipid peroxidation products, like malondialdehyde and conjugate diene, which represent biomarkers of oxidative stress. The histoarchitecture changes were also observed in the liver, muscle and gonads of BPS‐treated fish species. The present study showed that sub‐lethal exposure to BPS significantly influenced the activities of these enzymes and peroxidation byproducts. From this study, it is concluded that BPS‐caused toxic effects in fish species lead to an imbalance in the antioxidant defense system. It is clearly indicated that BPS toxicity could lead to susceptible oxidative stress in various tissues and could damage vital organs.

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“…In RWPE-1 cells, the incubation with BPS or BPF at doses ranging from 0 to 600 μM for 24 h showed imbalances in the levels of oxidative stress markers such as superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, as well as in the levels of glutathione and the total antioxidant capacity compared to the nonexposed groups [ 72 ]. Similarly, in hepatocytes exposed to BPS at doses ranging from zero to 500 μM for 24 h, results showed imbalances in the superoxide dismutase, catalase, and glutathione peroxidase levels [ 73 ]. Moreover, the MUC of BPF (detected in ≥85% of urinary samples) for adult individuals was significantly associated with imbalances in oxidative stress markers [ 74 ].…”

Section: Possible Mechanisms Of Actionmentioning

confidence: 99%

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Alharbi

Algonaiman

Alduwayghiri

et al. 2022

IJERPH

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Bisphenol A, a well-known endocrine-disrupting chemical, has been replaced with its analogs bisphenol S (BPS) and bisphenol F (BPF) over the last decade due to health concerns. BPS and BPF are present in relatively high concentrations in different products, such as food products, personal care products, and sales receipts. Both BPS and BPF have similar structural and chemical properties to BPA; therefore, considerable scientific efforts have investigated the safety of their exposure. In this review, we summarize the findings of relevant epidemiological studies investigating the association between urinary concentrations of BPS and/or BPF with the incidence of obesity or diabetes. The results showed that BPS and BPF were detected in many urinary samples at median concentrations ranging from 0.03 to 0.4 µg·L−1. At this exposure level, BPS median urinary concentrations (0.4 µg·L−1) were associated with the development of obesity. At a lower exposure level (0.1–0.03 µg·L−1), two studies showed an association with developing diabetes. For BPF exposure, only one study showed an association with obesity. However, most of the reported studies only assessed BPS exposure levels. Furthermore, we also summarize the findings of experimental studies in vivo and in vitro regarding our aim; results support the possible obesogenic effects/metabolic disorders mediated by BPS and/or BPF exposure. Unexpectedly, BPS may promote worse obesogenic effects than BPA. In addition, the possible mode of action underlying the obesogenic effects of BPS might be attributed to various pathophysiological mechanisms, including estrogenic or androgenic activities, alterations in the gene expression of critical adipogenesis-related markers, and induction of oxidative stress and an inflammatory state. Furthermore, susceptibility to the adverse effects of BPS may be altered by sex differences according to the results of both epidemiological and experimental studies. However, the possible mode of action underlying these sex differences is still unclear. In conclusion, exposure to BPS or BPF may promote the development of obesity and diabetes. Future approaches are highly needed to assess the safety of BPS and BPF regarding their potential effects in promoting metabolic disturbances. Other studies in different populations and settings are highly suggested.

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Bisphenol S leads to cytotoxicity-induced antioxidant responses and oxidative stress in isolated rainbow trout (Oncorhyncus mykiss) hepatocytes

Cited by 16 publications

References 59 publications

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study

Biochemical responses and antioxidant defense mechanisms in Channa Striatus exposed to Bisphenol S

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

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