Bisphenol A induces endoplasmic reticulum stress-associated apoptosis in mouse non-parenchymal hepatocytes

Asahi, Junpei; Kamo, Hanako; Baba, Ryoko; Doi, Yoshiaki; Yamashita, Akihisa; Murakami, Daisuke; Hanada, Ayuko; Hirano, Takeshi

doi:10.1016/j.lfs.2010.08.007

Cited by 119 publications

(71 citation statements)

References 37 publications

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“…These results were in harmony with Asahi et al, (2010) who assured that BPA increased the generation of reactive oxygen species. Also, Kabuto et al, (2003) found that BPA administration increases MDA levels in the tissue.…”

Section: Discussionsupporting

confidence: 84%

Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats

Edres¹,

Taha²,

Mandour³

et al. 2018

AJVS

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Key words:Bisphenol A, L-carnitine, Malondialdehyde, Hydronephrosis, GlutathioneThe present study aimed to explore the protective effects of L-carnitine on the oxidative stress induced by Bisphenol A (BPA) in rat kidneys. Forty male adult rats were allocated into four groups (10 rats each); placebo, BPA (50 mg/kg bwt per os), Lcarnitine (500 mg/kg bwt i.p), and the BPA/L-carnitine-treated group. After 70 days, blood and kidneys were collected for measurement of renal function, oxidative/antioxidative status, histopathological analyses, and gene expression of nrf2. BPA significantly increased serum urea and carnitine levels suggesting renal damage evidenced by hydropic degenerative changes and hydronephrosis. The level of malondialdehyde (MDA) in kidney was elevated along with decline in renal total antioxidant capacity (TAC) and reduced glutathione (GSH) concentrations following challenged with BPA. Notably, the expression of nrf2 mRNA transcript in kidney tissues was down-regulated after BPA-induced toxicity. L-carnitine treatment ameliorates the damaged effects of BPA on kidneys as indicated by low levels of serum urea and carnitine, and renal MDA. Further, L-carnitine enhances the antioxidants (TAC, and GSH), with up-regulation of nrf2 expression in kidney tissues. Our results suggest the renoprotective activity of L-carnitine in BPA-induced kidney injuries through induction of antioxidant system and modulation of oxidative stress.

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Section: Discussionsupporting

confidence: 84%

Impact of L-Carnitine on Bisphenol A-Induced Kidney Damage in Rats

Edres¹,

Taha²,

Mandour³

et al. 2018

AJVS

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“…2B). Cultured NCTC 1469 cell viability was slightly affected by DMSA-MNP at all incubation times and nanoparticle concentrations tested, whereas exposure of these cells to 100 µM BPA, used as a liver toxicity control [41], produced a significant decrease in cell viability. These data showed that DMSA-MNP have little toxicity in this cell line, with no notable influence on cell proliferation.…”

Section: In Vitro Dmsa-mnp Cytotoxicitymentioning

confidence: 92%

Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

Mejías

Gutiérrez

Salas

et al. 2013

Journal of Controlled Release

114

101

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Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little is known about their biotransformation and long-term toxicity in the body. Dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles have been proven efficient for in vivo drug delivery, but these results must nonetheless be sustained by comprehensive studies of long-term distribution, degradation and toxicity. We studied DMSA-coated magnetic nanoparticles effects in vitro on NCTC 1469 nonparenchymal hepatocytes, and analyzed their biodistribution and biotransformation in vivo in C57BL/6 mice. Our results indicate that DMSA-coated magnetic nanoparticles have little effect on cell viability, oxidative stress, cell cycle or apoptosis on NCTC 1469 cells in vitro. In vivo distribution and transformation was studied by alternating current magnetic susceptibility measurements, a technique that permits distinction of MNP from other iron species. Our results show that DMSA-coated MNP accumulate in spleen, liver and lung tissues for extended periods of time, in which nanoparticles undergo a process of conversion from superparamagnetic iron oxide nanoparticles to other nonsuperparamagnetic iron forms, with no significant signs of toxicity.

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“…73,225 These studies showed effects on liver enzymes and markers of oxidative stress, potential markers of liver function, at or below 10 -9 M; two other in vitro studies found effects of higher doses on similar endpoints. 226,227 In laboratory animals, four studies showed low dose effects on the expression of liver enzymes and hepatic gene expression (Fig. 1B).…”

Section: Integration Of Endpoints Across Levels Of Biological Organizmentioning

confidence: 97%