Low dose effects of bisphenol A

Vandenberg, Laura N.; Ehrlich, Shelley; Belcher, Scott M; Ben‐Jonathan, Nira; Dolinoy, Dana C.; Hugo, Eric R.; Hunt, Patricia A.; Newbold, Retha R.; Rubin, Beverly S.; Saili, Katerine S.; Soto, Ana M.; Wang, Hongsheng; Saal, Frederick S. vom

doi:10.4161/endo.26490

Cited by 176 publications

(78 citation statements)

References 271 publications

(211 reference statements)

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“…DNA methylation displayed non-monotonic dose-responses to continuous total and free liver tissue BPA level in human fetal liver samples, as well, suggesting STAT3 may be a translationally relevant candidate biomarker and supporting a growing body of literature on low dose effects of endocrine disruptors. 25 These data support STAT3 as a candidate biomarker for further testing, but do not support any statement of biological role or direct mechanistic link to either exposure or disease within the context of this study. However, STAT3 is a biologically feasible target for epigenetic shifts that impact liver tumor risk.…”

Section: Discussionmentioning

confidence: 88%

“…After 2 weeks on the respective diet, 8-week-old virgin females were mated with A vy /a males and were impregnated within 5 d. We estimated that daily BPA exposure levels, based on a dam weighing 25 g and consuming 5 g chow daily, were 0, 10 ng, 10 mg, and 10 mg/kg body weight per day for diets containing BPA at 0, 50 ng, 50 mg, and 50 mg/kg of diet, respectively. We chose these diets to capture both mean and maximum human environmental exposures to BPA, which were reported by Vandenberg et al 25 to range from 0.1 to 5 mg/kg body weight per day. In addition, BPA exposure within human relevant ranges was confirmed by direct measurement of BPA in liver tissue of a subset of exposed and control animals.…”

Section: Methodsmentioning

confidence: 99%

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Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health

et al. 2015

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Section: Discussionmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health

et al. 2015

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“…The environmental accumulation and abundance of BPA has sanctioned the extensive and longstanding exposure of animals and humans (Vandenberg et al, 2013). These chemicals can leach out of plastic products when heated and detectable amounts have been found in food and beverages (Brotons et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Testicular Functions and Sexual Behavior in Male Japanese Quail after Exposure to Bisphenol A

Hanafy¹,

Khalil²,

Abdel-Rahi³

et al. 2015

Asian J. of Poultry Science

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Recently, with the world progress of industries, several adverse factors such as Endocrine Disrupting Chemicals (EDCs) have appeared. These contaminants have negative devastating effects on the reproductive performance in a large number of domestic and wildlife animal species. Therefore, the objective of this study was to investigate the reproductive and physiological changes due to pre-pubertal exposure of Japanese quail males to Bisphenol A (BPA) as one of EDCs (BPA is a synthetic chemical acts as estrogenic effect). Three weeks old male quails were weekly injected intra-peritoneally (at 3, 4 and 5 weeks old) with BPA at doses of 0, 1, 5, or 10 mg kgG 1 b.wt. After 6 weeks exposure of BPA, time of sexual libido, semen characteristics, fertility percent, sexual organs development, histopathology of testes were examined and plasma testosterone concentrations were estimated. The results showed that BPA has adverse and deterioration effects on most of the studied traits. The males received 5 and 10 mg BPA showed significantly delayed time of sexual libido compared with control group. Also, males received 5 mg BPA showed significantly reduced semen volume and cloacal gland area compared with control males. The lowest initial motility and fertility percent (p#0.05) were detected in 10 mg group while the highest values were obtained in the control group. Males treated with 1 and 10 mg BPA had lower (p = 0.028) foam production than those produced in control males. Plasma concentrations of testosterone were significantly reduced (p<0.000) in all treated groups compared with control group. Histologically, the growth of the testes was negatively affected by exposure to/or over 1 mg kgG 1 BPA: Namely, the development of seminiferous tubules and spermatogenesis were severely inhibited compared with control testes. It could be concluded that exposure to estrogenic effects of environmental endocrine disruptors such as BPA before/at puberty lead to malformation of reproductive organs and reduction of reproductive capacity which appears not to regenerate in adult male quail.

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“…Therefore, these two will be the primary focus, although, where appropriate, effects of other EDCs on these traits will be discussed. BPA is one of the most widely prevalent EDCs with production currently reported to be in excess of 15 billion pounds per year (Vandenberg et al, 2013; Grandviewresearch, 2014). BPA is present in a wide variety of commonly used products and applications, including polycarbonate plastics, the lining of metal food cans, certain dental sealants, thermal receipt paper, and many other items that are currently not required to be labeled that they contain BPA.…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A and phthalate endocrine disruption of parental and social behaviors

Rosenfeld

2015

Front. Neurosci.

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Perinatal exposure to endocrine disrupting chemicals (EDCs) can induce promiscuous neurobehavioral disturbances. Bisphenol A and phthalates are two widely prevalent and persistent EDCs reported to lead to such effects. Parental and social behaviors are especially vulnerable to endocrine disruption, as these traits are programmed by the organizational-activational effects of testosterone and estrogen. Exposure to BPA and other EDCs disrupts normal maternal care provided by rodents and non-human primates, such as nursing, time she spends hunched over and in the nest, and grooming her pups. Paternal care may also be affected by BPA. No long-term study has linked perinatal exposure to BPA or other EDC and later parental behavioral deficits in humans. The fact that the same brain regions and neural hormone substrates govern parental behaviors in animal models and humans suggests that this suite of behaviors may also be vulnerable in the latter. Social behaviors, such as communication, mate choice, pair bonding, social inquisitiveness and recognition, play behavior, social grooming, copulation, and aggression, are compromised in animal models exposed to BPA, phthalates, and other EDCs. Early contact to these chemicals is also correlated with maladaptive social behaviors in children. These behavioral disturbances may originate by altering the fetal or adult gonadal production of testosterone or estrogen, expression of ESR1, ESR2, and AR in the brain regions governing these behaviors, neuropeptide/protein hormone (oxytocin, vasopressin, and prolactin) and their cognate neural receptors, and/or through epimutations. Robust evidence exists for all of these EDC-induced changes. Concern also exists for transgenerational persistence of such neurobehavioral disruptions. In sum, evidence for social and parental deficits induced by BPA, phthalates, and related chemicals is strongly mounting, and such effects may ultimately compromise the overall social fitness of populations to come.

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Low dose effects of bisphenol A

Cited by 176 publications

References 271 publications

Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health

Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health

Testicular Functions and Sexual Behavior in Male Japanese Quail after Exposure to Bisphenol A

Bisphenol A and phthalate endocrine disruption of parental and social behaviors

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