Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Sharma, Prince; Chadha, Pooja

doi:10.1016/j.sjbs.2021.04.088

Cited by 30 publications

(24 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since BPA is present in waters, both fresh and salty [ 23 , 24 , 25 , 26 ], it is also absorbed by the organisms that are living in them. BPA is usually toxic to aquatic organisms [ 27 , 28 , 29 ]. However, some aquatic organisms, such as the Mediterranean mussel Mytilus galloprovincialis [ 30 ] and the Green-eared Mussel Perna viridis [ 31 ] or marine fish [ 32 , 33 , 34 , 35 ], are capable of accumulating BPA in the muscles and liver.…”

Section: Introductionmentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

View full text Add to dashboard Cite

BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.

show abstract

Section: Introductionmentioning

confidence: 99%

Can Antioxidants Reduce the Toxicity of Bisphenol?

2022

View full text Add to dashboard Cite

show abstract

“…Exposure to BPA results in decreased levels of antioxidant enzymes. A reduced level of SOD and CAT was reported by Sharma and Chadha [47] in BPA exposed C. punctatus. The level of SOD and CAT was also found to decrease significantly in BPA administered rats [48,49].…”

Section: Discussionmentioning

confidence: 62%

“…BPA has also been reported to cause DNA damage in RWPE-1 cells as the tail intensities were found to be increased significantly as compared to control [ 58 ]. Sharma and Chadha [ 47 ] also observed DNA damage in BPA exposed C. punctatus. In the present study, treatment with S. commune (Sch1) extract effectively protected DNA from damage caused by the genotoxic compound, BPA.…”

Section: Discussionmentioning

confidence: 96%

“…Channa punctatus was exposed to genotoxic compound BPA to induce oxidative stress. There are several studies which state that BPA is responsible for the generation of oxidative stress and also causes DNA damage [45][46][47]. Exposure to BPA results in decreased levels of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…BPA was used to induce oxidative stress and genotoxicity. A sub lethal dose (3.81 mg/l), half of LC 50 determined in previous study conducted in our lab [ 47 ] was used. Group I: normal healthy control; Group II: BPA; Group III: BPA + S. commune (Sch1) extract (5 mg/100 g body weight); Group IV: BPA + S. commune extract (10 mg/100 g body weight).…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

An endophytic Schizophyllum commune possessing antioxidant activity exhibits genoprotective and organprotective effects in fresh water fish Channa punctatus exposed to bisphenol A

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Oxidative stress is responsible for the onset of several chronic and degenerative diseases. Exogenous supply of antioxidants is reported to neutralize the effects of oxidative stress. Several synthetic antioxidants suffer from various side effects which necessitates the exploration of antioxidant compounds from natural sources. Endophytic fungi residing in the plants are gaining the attention of researchers as a source of novel antioxidants. Majority of the research conducted so far on endophytic fungi has been restricted to the members of phylum ascomycota. Basidiomycota, inspite of their immense bioactive potential remain relatively unexploited. This study aimed to assess the ameliorative effects of an endophytic Schizophyllum commune (basidiomycetous fungus) against oxidative stress associated altered antioxidant levels, genotoxicity and cellular damage to different organs in bisphenol A exposed fresh water fish Channa punctatus. Results Good antioxidant and genoprotective potential was exhibited by S. commune extract in in vitro studies conducted using different antioxidant, DNA damage protection, and cytokinesis blocked micronuclei assays. In vivo studies were performed in fresh water fish Channa punctatus exposed to bisphenol A. A significant decrease in the considered parameters for DNA damage (% micronuclei and comet assay) were recorded in fish treated with S. commune extract on comparison with untreated bisphenol A exposed group. The S. commune extract treated fish also exhibited an increase in the level of antioxidant enzymes viz. catalase, superoxide dismutase and glutathione reductase as well as histoprotective effect on various organs. GC-MS analysis revealed the presence of 3-n-propyl-2,4-pentanedione, n-heptadecanol-1, trans-geranylgeraniol, 3-ethyl-2-pentadecanone, 1-heneicosanol and squalene as some of the compounds in S. commune extract. Conclusion The study highlights the significance of an endophytic basidiomycetous fungus S. commune as a source of antioxidant compounds with possible therapeutic potential.

show abstract

The effect of bisphenol A on antioxidant defense and the structure and function of the liver of Siberian sturgeon (Acipenser baerii)

Khorshidi,

Salati,

Keyvanshokooh

2024

Microscopy Res & Technique

View full text Add to dashboard Cite

The present study was conducted to investigate the biochemical and histological changes of liver tissue in Siberian sturgeon (Acipenser baerii) exposed to different doses of bisphenol A (BPA). One hundred and eighty pieces of 1‐year‐old A. baerii with an average weight of 200–250 g bought and randomly distributed in 18 tanks (n = 10). After 2 weeks of adaptation, the fish received intraperitoneal injections of 1, 10, and 100 μg/g/week BPA and μg/g/week of 17β‐estradiol intraperitoneally. The solvent control group received only peanut oil, while the control group did not receive any injections. In order to investigate histological changes of the liver, after 2 weeks the liver samples were taken, fixed in 10% formalin solution and slides prepared by routine histological methods. For assaying antioxidant defense status, the liver tissue from three fish of each replicates was captured and after homogenization, activity of catalase, superoxide dismutase, and glutathione peroxidase and malondialdehyde measured. The most important histological changes observed in the liver tissue were: vacuolation of hepatocytes, nuclear hypertrophy, necrosis of liver cells, expansion of sinusoids, and accumulation of fat cells. In the highest dose, the intensity of tissue changes increased. Activity of antioxidant enzymes and malondialdehyde content increased in fish exposed to 100 μg/g/week BPA in compare with other groups (p < .05). According to our findings, it could be concluded that liver histology was affected by BPA and tissue damage had occurred, which had led to changes in blood parameters. Also, the obtained results showed that the high concentrations of BPA used in this study stimulate the antioxidant defense.Research Highlights BPA evoke oxidative stress in Siberian sturgeons in high dose of exposure. Severity of liver histologic lesions was dose dependent.

show abstract

Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Abstract: Graphical abstract

Cited by 30 publications

References 90 publications

Can Antioxidants Reduce the Toxicity of Bisphenol?

Can Antioxidants Reduce the Toxicity of Bisphenol?

An endophytic Schizophyllum commune possessing antioxidant activity exhibits genoprotective and organprotective effects in fresh water fish Channa punctatus exposed to bisphenol A

The effect of bisphenol A on antioxidant defense and the structure and function of the liver of Siberian sturgeon (Acipenser baerii)

Contact Info

Product

Resources

About