Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster

Antony, Anet; Olakkaran, Shilpa; Purayil, Anupama Kizhakke; Puttaswamygowda, Gurushankara Hunasanahally

doi:10.1016/j.jhazmat.2018.07.050

Cited by 59 publications

(17 citation statements)

References 49 publications

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“…( Park and Choi, 2009 ) studied the effect of nonylphenol and bisphenol A on Daphnia magna and Chironomus riparius and observed increased MDA content and decreased activity of CAT in both chemical exposed groups. ( Anet et al, 2019 ) observed increased lipid peroxidation and decreased SOD, CAT, GSH, and GST activities in Drosophila melanogaster treated with BPA. ( Tiwari and Vanage, 2017 ) demonstrated bisphenol A-induced lipid peroxidation and decrease in the activity of various enzymatic and non-enzymatic antioxidants in bone marrow cells, blood lymphocytes, and testicular and epidermal tissues of male rats.…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Sharma

Chadha

2021

Saudi Journal of Biological Sciences

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Section: Discussionmentioning

confidence: 99%

Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Sharma

Chadha

2021

Saudi Journal of Biological Sciences

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“…In the present study, we found that BPA exposure caused a significant decrease in the gene expression of SOD1, SOD2, Gpx2, and catalase. Anet et al [ 60 ] studied the effects of BPA exposure on oxidative damage and genotoxicity in the common fruit fly ( Drosophila melanogaster ) and found that BPA not only resulted in increased ROS and lipid peroxidation, but also reduced the protein expression of antioxidant enzymes. However, the BPA + R30 treatments effectively attenuated the BPA-induced decrease in the gene expression of antioxidant enzymes.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Liao

Chen

Shih

et al. 2021

IJMS

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Resveratrol can affect the physiology or biochemistry of offspring in the maternal–fetal animal model. However, it exhibits low bioavailability in humans and animals. Fifteen-week SD pregnant female rats were orally administered bisphenol A (BPA) and/or resveratrol butyrate ester (RBE), and the male offspring rats (n = 4–8 per group) were evaluated. The results show that RBE treatment (BPA + R30) compared with the BPA group can reduce the damage caused by BPA (p < 0.05). RBE enhanced the expression of selected genes and induced extramedullary hematopoiesis and mononuclear cell infiltration. RBE increased the abundance of S24-7 and Adlercreutzia in the intestines of the male offspring rats, as well as the concentrations of short-chain fatty acids (SCFAs) in the feces. RBE also increased the antioxidant capacity of the liver by inducing Nrf2, promoting the expression of HO-1, SOD, and CAT. It also increased the concentration of intestinal SCFAs, enhancing the barrier formed by intestinal cells, thereby preventing BPA-induced metabolic disruption in the male offspring rats, and reduced liver inflammation. This study identified a potential mechanism underlying the protective effects of RBE against the liver damage caused by BPA exposure during the peri-pregnancy period, and the influence of the gut microbiota on the gut–liver axis in the offspring.

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“…In random skin flaps, post-ischemic reperfusion induces oxidative stress and apoptosis, leading to tissue damage ( Kosuru et al, 2018 ). In the early stages of oxidative stress, ROS react with cell membrane lipids and proteins, triggering peroxidation and destruction of cells ( Anet et al, 2018 ). As a marker of lipid peroxidation, the MDA level reflects the extent of tissue injury ( Tsikas, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

Lin

et al. 2018

Front. Pharmacol.

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Random-pattern skin flap transplantation is frequently applied in plastic and reconstructive surgery. However, the distal part of the flap often suffers necrosis due to ischemia. In this study, the effects of salvianolic acid B (Sal B) on flap survival were evaluated, and the underlying mechanisms were investigated. Sal B improved the survival area, reduced tissue edema, and increased the number of microvessels in skin flaps after 7 days, whereas an autophagy inhibitor (3-methyladenine) reversed the Sal B-induced increase in flap viability. In addition, Sal B stimulated angiogenesis, inhibited apoptosis, reduced oxidative stress, and upregulated autophagy in areas of ischemia. Moreover, the effects of Sal B on angiogenesis, apoptosis, and oxidative stress were reversed by autophagy inhibition. Overall, our findings suggest that Sal B has pro-angiogenesis, anti-apoptosis, and anti-oxidative stress effects by stimulating autophagy, which enhances the survival of random-pattern skin flaps.

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Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster

Cited by 59 publications

References 49 publications

Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Bisphenol A induced toxicity in blood cells of freshwater fish Channa punctatus after acute exposure

Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota

Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy

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