Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes

Masuno, Hiroshi; Kidani, Teruki; Sekiya, Keizo; Sakayama, Kenshi; Shiosaka, Takahiko; Yamamoto, Haruyasu; Honda, Katsuya

doi:10.1016/s0022-2275(20)30108-5

Cited by 206 publications

(28 citation statements)

References 47 publications

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“…The expression of PPARγ, C/EBPα, and LPL was upregulated in abdominal adipocytes of adult female rats. Masuno et al (2001) reported that BPA can increase the activity of LPL and the accumulation of TG in 3T3-L1 cells, leading to its differentiation into adipocytes with larger lipid droplets [ 66 ]. The staining of tissue sections in this study also yielded similar results ( Figure 1 and Figure 2 ).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

et al. 2021

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Resveratrol butyrate esters (RBE) are derivatives of resveratrol (RSV) and butyric acid and exhibit biological activity similar to that of RSV but with higher bioavailability. The aim of this study was designed as an animal experiment to explore the effects of RBE on the serum biochemistry, and fat deposits in the offspring rats exposed to bisphenol A (BPA), along with the growth and decline of gut microbiota. We constructed an animal model of perinatal Bisphenol A (BPA) exposure to observe the effects of RBE supplementation on obesity, blood lipids, and intestinal microbiota in female offspring rats. Perinatal exposure to BPA led to weight gain, lipid accumulation, high levels of blood lipids, and deterioration of intestinal microbiota in female offspring rats. RBE supplementation reduced the weight gain and lipid accumulation caused by BPA, optimised the levels of blood lipids, significantly reduced the Firmicutes/Bacteroidetes (F/B) ratio, and increased and decreased the abundance of S24-7 and Lactobacillus, respectively. The analysis of faecal short-chain fatty acid (SCFA) levels revealed that BPA exposure increased the faecal concentration of acetate, which could be reduced via RBE supplementation. However, the faecal concentrations of propionate and butyrate were not only significantly lower than that of acetate, but also did not significantly change in response to BPA exposure or RBE supplementation. Hence, RBE can suppress BPA-induced obesity in female offspring rats, and it demonstrates excellent modulatory activity on intestinal microbiota, with potential applications in perinatological research.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

et al. 2021

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“…Some EDCs influence gene expression, including expression of genes related to lipid storage [ 15 , 16 ]. Tributyltin also has epigenetic effects [ 29 ], although it is unknown if these effects extend to genes related to lipid accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…Many of these chemicals work indirectly through epigenetic mechanisms by affecting key genes linked to obesity. Specifically, phthalate esters such as bisphenol-a and mono-(2-ethylhexyl) phthalate upregulate adipocyte or lipogenic genes which can lead to obese phenotypes [ 15 , 16 ]. Additionally, EDCs can act directly on the HPT axis by altering levels of circulating thyroid hormones (triiodothyronine [T 3 ] and thyroxine [T 4 ]) which regulate, among other things, lipid metabolism [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish

Minicozzi

Axlid²,

Hippel³

et al. 2021

PLoS ONE

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Perchlorate is a water-soluble contaminant found throughout the United States and many other countries. Perchlorate competitively inhibits iodide uptake at the sodium/iodide symporter, reducing thyroid hormone synthesis, which can lead to hypothyroidism and metabolic syndromes. Chronic perchlorate exposure induces hepatic steatosis and non-alcoholic fatty liver disease (NAFLD) in developing threespine stickleback (Gasterosteus aculeatus). We hypothesized that perchlorate would also induce zebrafish (Danio rerio) to develop phenotypes consistent with NAFLD and to accumulate lipids throughout the body. We exposed zebrafish embryos to four concentrations of perchlorate treated water (10μg/L, 10mg/L, 30mg/L, and 100mg/L) and a control (0mg/L) over the course of 133 days. Adult zebrafish were euthanized, sectioned, H&E and Oil Red-O stained, and analyzed for liver morphology and whole body lipid accumulation. In a representative section of the liver, we counted the number of lipid droplets and measured the area of each droplet and the total lipid area. For whole body analysis, we calculated the ratio of lipid area to body area within a section. We found that zebrafish exposed to perchlorate did not differ in any measured liver variables or whole body lipid area when compared to controls. In comparison to stickleback, we see a trend that control stickleback accumulate more lipids in their liver than do control zebrafish. Differences between the species indicate that obesogenic effects due to perchlorate exposure are not uniform across fish species, and likely are mediated by evolutionary differences related to geographic location. For example, high latitude fishes such as stickleback evolved to deposit lipid stores for over-winter survival, which may lead to more pronounced obesogenic effects than seen in tropical fish such as zebrafish.

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“…In contrast from the foregoing, a finding revealed that chronic BPA administration to rats for 3 months did not bring about a change in body weight, fat storage or a rise in triglyceride level [3]. It was also revealed that by utilizing 3T3-F442A, adipocytes and BPA invigorated insulin-dependent glucose uptake with augmented Glut4 expression in an animal model [4][5][6].…”

Section: DImentioning

confidence: 92%

Histopathological changes associated with exposure of some viscerals and testicular tissues to bisephenol A and di(2-ethylhexyl)phthalate

Omorodion¹,

Atoigwe-Ogeyemhe²,

Achukwu³

et al. 2021

Trop. J. Pharm Res

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Purpose: To evaluate the pathological effect associated with the exposure of viscerals and testicular tissues of albino rats to BPA and DEHP. Methods: A total of sixty adult male Wistar rats weighing 200 – 250 g were divided into four (4) groups of 15 rats per cage in a sanitized environment. Group I animals received normal rodent pellet and water and served as untreated group. Thereafter, the rats in the second group (II) were administered 5 mg/kg per day of BPA mixed with rodent pellet orally; group III received 0.5 mg/kg daily dose of DEHP mixed with rodent pellet; while group IV received orally mixture of 0.5 mg/kg of BPA and 0.5 mg/kg DEHP + pelleted rodent feed. The rats were fed and water provided regularly for 30 days; finally, the animals were weighed and sacrificed by cranial dislocation. Result: BPA and DEHP resulted in significant (p < 0.05) weight losses, inflammation and fatty deposits in the liver, degenerated bowman capsule and glomeruli of the kidneys, lung oedema, and deteriorated leydig cells in testes. Conclusion: The results suggest that BPA and DEHP cause significant weight loss and are injurious to the cellular make-up of rat tissues, which may be the same in higher animals.

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Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes

Cited by 206 publications

References 47 publications

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish

Histopathological changes associated with exposure of some viscerals and testicular tissues to bisephenol A and di(2-ethylhexyl)phthalate

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