Bisphenol A Does Not Affect Memory Performance in Adult Male Rats

Kuwahara, Rika; Kawaguchi, Shinichiro; Kohara, Yumi; Jojima, Takeshi; Yamashita, Kimihiro

doi:10.1007/s10571-013-0017-6

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…As an endocrine disrupting chemical (EDC) that can bind and activate estrogen receptors, as well as other steroidogenic and non-steroidogenic receptors (Lee et al, 2003; Vandenberg et al, 2009; Wetherill et al, 2002; Xu et al, 2005; Zoeller et al, 2005), BPA exposure may negatively impact this cognitive process. Several assessments have been developed that specifically measure spatial navigational learning and memory in rodents, including the Barnes maze, Morris water maze, radial arm maze, and appetite-motivated maze tests (Barnes, 1979; Kuwahara et al, 2014; Morris, 1984; Olton, 1976; Sharma et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

“…Some reports have suggested that BPA exposure impairs spatial learning and memory (Diaz Weinstein et al, 2013; Eilam-Stock et al, 2012; Goncalves et al, 2010; Jasarevic et al, 2011; Jasarevic et al, 2013; Kim et al, 2011; Kuwahara et al, 2013; Viberg et al, 2011; Xu et al, 2013); while others suggest minimal or no BPA effects on spatial navigation (Ferguson et al, 2012; Kuwahara et al, 2014; Neese et al, 2013; Ryan and Vandenbergh, 2006; Sadowski et al, 2014a; Williams et al, 2013). Differences in species, age at and/or route of exposure, BPA dose, and testing methods may account for those varying results.…”

Section: Introductionmentioning

confidence: 99%

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Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

Johnson

Javurek

Painter

et al. 2016

Hormones and Behavior

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Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of a wide variety of items. Previous studies suggest BPA exposure may result in neuro-disruptive effects; however, data are inconsistent across animal and human studies. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether female and male rats developmentally exposed to BPA demonstrated later spatial navigational learning and memory deficits. Pregnant NCTR Sprague-Dawley rats were orally dosed from gestational day 6 to parturition, and offspring were directly orally dosed until weaning (postnatal Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ) and a 0.5 μg/kg/day ethinyl estradiol (EE)-reference estrogen dose. At adulthood, 1/sex/litter was tested for seven days in the Barnes maze. The 2500 BPA group sniffed more incorrect holes on day 7 than those in the control, 2.5 BPA, and EE groups. The 2500 BPA females were less likely than control females to locate the escape box in the allotted time (P value= 0.04). Although 2.5 BPA females exhibited a prolonged latency, the effect did not reach significance (P value = 0.06), whereas 2.5 BPA males showed improved latency compared to control males (P value = 0.04), although the significance of this result is uncertain. No differences in serum testosterone concentration were detected in any male or female treatment groups. Current findings suggest developmental exposure of rats to BPA may disrupt aspects of spatial navigational learning and memory. HHS Public Access

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

Johnson

Javurek

Painter

et al. 2016

Hormones and Behavior

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“…In addition, fear-related behaviors were altered by BPA in mice (Matsuda et al, 2013) and rats (Negishi et al, 2004). In the elevated plus maze (EPM), exposure of rats to BPA produced anxiogenic effects (Patisaul and Bateman, 2008;Patisaul et al, 2012;Diaz Weinstein et al, 2013;Zhou et al, 2015), anxiolytic effects (Farabollini et al, 1999;Fujimoto et al, 2013;Kuwahara et al, 2014), or unclear/nonexistent effects (Negishi et al, 2004;Fujimoto et al, 2006;Jones and Watson, 2012;Kuwahara et al, 2013). The different reported effects of BPA in rats in the EPM might be due to differences in experimental design or environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor

et al. 2015

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Bisphenol A (BPA) is an environmental endocrine disrupter (EED). Previous studies by our group showed that pre- and postnatal administration of low-level BPA induced depression-like behavior in rats. In this study, we evaluated the effects of prenatal BPA on behavioral responses to a predator odor by using a novel cross-form apparatus consisting of 4 plastic chambers. On the first day, nothing was placed into the chambers (Session 1). On the second day, a predator odor (fox odor) was located in separate chambers at 2 opposite corners of the apparatus (Session 2). Pregnant Wistar rats were exposed to low-dose BPA (less than the reference dose) during the 7 days just before birth, and the offspring of the treated rats were evaluated as adults. The locomotor activity and avoidance response of each rat on both test days were compared. The control and BPA groups showed reduced locomotor activity in the presence of the predator odor, but the odor-avoidance response was significant only in the BPA rats. The BPA-exposed rats were obviously sensitive to the predator odor. These results suggest that prenatal BPA exposure has an amplifying effect on avoidance responses to predator odor stress.

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“…The apparatus and the experimental procedures were adopted from our previous study (Kuwahara et al, 2014). The apparatus (Fig.…”

Section: Maze Testmentioning

confidence: 99%

“…The effective dose of NP, from a neurobehavioral standpoint, is much lower than the dosage associated with general toxicity (Negishi et al, 2004). Our present study was, therefore, designed to evaluate the effects of oral exposure to low dose of NP on learning and memory performance, general activity levels, and emotionality in male and female Sprague-Dawley (SD) rats using a battery of behavioral tests, including a series of learning performance tests previously used in our laboratory (Kuwahara et al, 2014). To our knowledge, this is the first study investigating the effects of oral NP administration on CNS in male and female rats.…”

Section: Introductionmentioning

confidence: 99%

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

et al. 2015

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-Nonylphenol ethoxylate (NPE) is a non-ionic surfactant, that is degraded to short-chain NPE and 4-nonylphenol (NP) by bacteria in the environment. NP, one of the most common environmental endocrine disruptors, exhibits weak estrogen-like activity. In this study, we investigated whether oral administration of NP (at 0.5 and 5 mg/kg doses) affects spatial learning and memory, general activity, emotionality, and fear-motivated learning and memory in male and female Sprague-Dawley (SD) rats. SD rats of both sexes were evaluated using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) that was used to assess spatial learning and memory. In the MAZE test, the time required to reach the reward in male rats treated with 0.5 mg/kg NP group and female rats administered 5 mg/kg NP was significantly longer than that for control animals of the corresponding sex. In other behavioral tests, no significant differences were observed between the control group and either of the NP-treated groups of male rats. In female rats, inner and ambulation values for animals administered 0.5 mg/kg NP were significantly higher than those measured in control animals in open-field test, while the latency in the group treated with 5 mg/kg NP was significantly shorter compared to the control group in step-through passive avoidance test. This study indicates that oral administration of a low-dose of NP slightly impairs spatial learning and memory performance in male and female rats, and alters emotionality and fear-motivated learning and memory in female rats only.

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Bisphenol A Does Not Affect Memory Performance in Adult Male Rats

Cited by 10 publications

References 25 publications

Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study

Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

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