Bisphenol A contamination in infant rats: molecular, structural, and physiological cardiovascular changes and the protective role of kefir

Friques, Andreia G. F.; Santos, Fernanda D.N.; Angeli, Daiany B.; Silva, Fernanda Aldrigues Crispim; Dias, Ananda T.; Aires, Rafaela; Leal, Marcos André Soares; Nogueira, Breno Valentim; Amorim, Fernanda Gobbi; Campagnaro, Bianca Prandi; Pereira, Thiago de Melo Costa; Campos‐Toimil, Manuel; Meyrelles, Silvana S.; Vasquez, Elisardo C.

doi:10.1016/j.jnutbio.2019.108254

Cited by 19 publications

(17 citation statements)

References 70 publications

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“…Based on genetic sequence analysis of samples of meconium and feces [ 10 ], the general opinion is that the gut microbiota starts in the newborn under the influence of the health conditions of the prenatal mother’s health, gestational age, mode of delivery, type of feeding, quality of environment and exposure to toxins (see Figure 2 , the schematic time course of evolution of the gut microbiota from infants to elderly people) [ 10 , 11 , 12 , 13 , 14 ]. Therefore, once the appropriate composition was established, the symbiotic community could be considered an incredible legion of 10 9 to 10 12 warriors composed of five main phyla.…”

Section: Gut Microbiota: An Extraordinary Army Of Fighters To Defend the Hostmentioning

confidence: 99%

“…The first role of the gut microbiota is to protect the host against pathogenic microorganisms and to neutralize the effects of toxins and/or drugs [ 12 , 13 , 14 ]. The second role is to provide essential metabolites/vitamins, facilitating the absorption of ions and molecules and thus generating an additional source of energy for colonocytes [ 15 ].…”

Section: Gut Microbiota: An Extraordinary Army Of Fighters To Defend the Hostmentioning

confidence: 99%

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

et al. 2021

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The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) or Parkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has been a permanent challenge to science. New tools were developed over the past two decades and were immediately incorporated into routines in many laboratories, but the most valuable scientific contribution was the “waking up” of the gut microbiota. Disturbances in the gut microbiota, such as an imbalance in the beneficial/pathogenic effects and a decrease in diversity, can result in the passage of undesired chemicals and cells to the systemic circulation. Recently, the potential effect of probiotics on restoring/preserving the microbiota was also evaluated regarding important metabolite and vitamin production, pathogen exclusion, immune system maturation, and intestinal mucosal barrier integrity. Therefore, the focus of the present review is to discuss the available data and conclude what has been accomplished over the past two decades. This perspective fosters program development of the next steps that are necessary to obtain confirmation through clinical trials on the magnitude of the effects of kefir in large samples.

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Section: Gut Microbiota: An Extraordinary Army Of Fighters To Defend the Hostmentioning

confidence: 99%

Section: Gut Microbiota: An Extraordinary Army Of Fighters To Defend the Hostmentioning

confidence: 99%

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

et al. 2021

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“…Experimental rat model reveals that administered of bisphenol-A 0.1 mg/kg/day for 60 consecutive days, inhibits acetylcholine-induced relaxation and also associated with NOS and COX blockage, increased levels of NADP+ with elevating the level of ROS/RNS resulting in impaired endothelial function. The model also states the involvement of prostanoids, increase levels of which results in vasoconstriction (Friques et al, 2020). It is worthwhile to note that administration of bisphenol-A through contaminated drinking water (4 nM to 400 µM) for 30 days to CD11 mice is found to increase Ang-II expression which uncouples eNOS from its co-factors like FMN, BH-4, promoting oxidative stress.…”

Section: Bisphenol-a-inducedmentioning

confidence: 99%

Experimental models for vascular endothelial dysfunction

.¹,

Gupta²,

Tomar

et al. 2021

Bangladesh J Pharmacol

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Vascular endothelial dysfunction is characterized by apoptosis of endothelial cells, an imbalance between vasoconstrictory and vasodilatory substances, the imbalance between ROS and antioxidants, vascular remodeling, loss of vascular integrity which leads to an increased risk of cardiovascular complications. To date, no therapeutic intervention is available as a promising agent. This may be due to a poor understanding of the underlying mechanism involved in vascular endothelial dysfunction in the pathogenesis. Animal models sharing identical features as that of humans are paramount to understand fundamental physiology, mechanism and to explore new targets for developing therapeutic agents. Thus, it becomes mandatory to re-explore the available animal models for a better understanding of molecular pathways involving vascular endothelial dysfunction. The purpose of this paper is to review different models for vascular endothelial dysfunction to the outlook for developing new drugs to treat vascular endothelial dysfunction.

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“…Therefore, BPA affects estrogen receptor functions and also other nuclear hormone receptors (Fenichel et al, 2013). In recent years, exposure to BPA has been associated with a wide range of metabolic, reproductive, cardiovascular and neurological diseases and also with increased incidences of endocrine diseases and endocrine-related cancers (Dunder et al, 2019;Friques et al, 2020;Hafezi and Abdel-Rahman, 2019;Hu et al, 2019;Khan et al, 2019;Piao et al, 2019;Santoro et al, 2019;Shu et al, 2019;Win-Shwe et al, 2019). These effects are mediated by hormonal regulation and metabolic signals, mainly by nuclear receptors, or by mechanisms that are currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

et al. 2020

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Bisphenol-A (BPA) used in the production of plastic materials is a temperature-soluble agent. It also has a steroid hormone-like activity; therefore, it poses a danger to human health. In our study, we aimed to investigate the effects of BPA on lymph node and spleen in male rats exposed to this agent during prenatal stage. The pregnant female rats were divided into four groups: control, sham, low dose (300 µg/kg BPA), and high dose (900 µg/kg BPA). BPA was dissolved in 1 mL of corn oil and administered to the pregnant rats every day during pregnancy. On the 21st and 45th day after the birth, male rats’ lymph node and spleen samples were taken and histopathological examination was performed. Samples were stained with hematoxylin and eosin to determine the general histological appearance, and with CD3 and CD20 immunohistochemically. The results of staining were evaluated by H-score, and statistical analysis was performed. In the samples, BPA applications were not found to cause significant tissue damage. But there was a significant decrease in the immunoreactivities of CD3 and CD20 after BPA applications in both 21st and 45th day samples. After high dose BPA administration, decreased CD3 immunoreactivity was statistically significant. It is thought that BPA does not cause histologically significant tissue damage, but it may impair organ function at cellular level. The investigation of molecules involved in organ function will be useful in revealing the mechanisms that will cause dysfunction.

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Bisphenol A contamination in infant rats: molecular, structural, and physiological cardiovascular changes and the protective role of kefir

Cited by 19 publications

References 70 publications

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Experimental models for vascular endothelial dysfunction

Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

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