Bisphenol A, Chlorinated Derivatives of Bisphenol A and Occurrence of Myocardial Infarction in Patients with Type 2 Diabetes: Nested Case-Control Studies in Two European Cohorts

Hu, Chunyun; Schöttker, Ben; Venisse, Nicolas; Limousi, Frédérike; Saulnier, Pierre Jean; Albouy-Llaty, Marion; Dupuis, Antoine; Brenner, Hermann; Migeot, Virginie; Hadjadj, Samy

doi:10.1021/acs.est.9b02963

Cited by 38 publications

(14 citation statements)

References 45 publications

(67 reference statements)

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“…Previous studies have reported that urinary BPA is positively associated with an increased prevalence of total CVD in the U.S. population (Cai et al 2020;Hu et al 2019). Another study has shown a positively association between BPA and CVD (Melzer et al 2010).…”

Section: Discussionmentioning

confidence: 96%

The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

wang¹,

Fei²,

Liu³

et al. 2021

Preprint

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Background Bisphenol F (BPF) and bisphenol S (BPS) are replacing bisphenol A (BPA) in the manufacturing of products containing polycarbonates and epoxy resins, however, the effects of these substitutes on the risk of cardiovascular disease (CVD) have not been assessed. Objective To examine the association of urinary BPS and BPF with the CVD risk in a U.S. representative population. Method A cross-sectional data with 1,266 participants aged 20 to 80 years from the 2013–2016 National Health and Nutrition Examination Survey (NHANES) was analyzed. The logistic regression was used to assess the association between BPF, BPS and CVD. The Bayesian kernel machine regression (BKMR) model was applied to assess the mixed effect. Results A total of 138 patients with CVD were identified. After adjusting for potential confounding factors, T3 concentration of BPS increased the risk of total CVD (OR: 1.98, 95%CI: 1.20–3.28). When stratified by age, we found that BPS increased the risk of CVD in the 50–80 age groups (OR:1.40, 95%CI: 1.05–1.87). BPS was positively associated with the risk of stroke and T3 of BPS increased the stroke risk by 3.46 times (95%CI: 1.09–10.95). No significant association was observed between BPF and CVD. Although BKMR model did not identify the mixed exposure effect of BPS, the risk of CVD increased, with the increase of compound concentration. Conclusion Our results suggest that BPS may increase the risk of total CVD and stroke in the U.S population, and prospective studies are needed to confirm the results.

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Section: Discussionmentioning

confidence: 96%

The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

wang¹,

Fei²,

Liu³

et al. 2021

Preprint

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“…Several epidemiological investigations have been developed to assess the cardiotoxic effects of BPA. The evidence is consistent, reporting that there is an association between exposure to BPA and an increased prevalence of CVDs [ 103 , 104 ] including atherosclerosis [ 105 ], coronary artery disease (CAD) [ 104 , 106 , 107 , 108 , 109 ], peripheral artery disease (PAD) [ 110 ], dilated cardiomyopathy (DCM) [ 109 ], and myocardial infarction (MI) [ 104 , 111 ]; heart failure; and angina pectoris [ 104 ] and its risk factors, such as hypertension [ 112 , 113 , 114 , 115 ] and diabetes [ 103 , 108 ] ( Figure 2 ). There is a multiplicity of different analytical techniques to quantify BPA concentrations in human tissues.…”

Section: Effects Of Bpa On Humansmentioning

confidence: 99%

“…The authors demonstrated the exposure to BPA in the two studies (ESTHER cohort: 31% and SURDIAGENE cohort: 38%). The meta-analysis of the results showed that in booth cohorts, there exists a positive association between MI and the detection of BPA in urine (OR = 1.97; 95% CI = 1.05–3.70, p = 0.04) [ 111 ]. More recently, in 2020, Cai et al evaluated the relationship between urinary BPA levels and CVDs in the U.S. adult population using data from NHANES 2003–2014.…”

Section: Effects Of Bpa On Humansmentioning

confidence: 99%

Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review

Fonseca

Lorigo

2022

JoX

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Currently, the plastic monomer and plasticizer bisphenol A (BPA) is one of the most widely used chemicals. BPA is present in polycarbonate plastics and epoxy resins, commonly used in food storage and industrial or medical products. However, the use of this synthetic compound is a growing concern, as BPA is an endocrine-disrupting compound and can bind mainly to estrogen receptors, interfering with different functions at the cardiovascular level. Several studies have investigated the disruptive effects of BPA; however, its cardiotoxicity remains unclear. Therefore, this review’s purpose is to address the most recent studies on the implications of BPA on the cardiovascular system. Our findings suggest that BPA impairs cardiac excitability through intracellular mechanisms, involving the inhibition of the main ion channels, changes in Ca2+ handling, the induction of oxidative stress, and epigenetic modifications. Our data support that BPA exposure increases the risk of developing cardiovascular diseases (CVDs) including atherosclerosis and its risk factors such as hypertension and diabetes. Furthermore, BPA exposure is also particularly harmful in pregnancy, promoting the development of hypertensive disorders during pregnancy. In summary, BPA exposure compromises human health, promoting the development and progression of CVDs and risk factors. Further studies are needed to clarify the human health effects of BPA-induced cardiotoxicity.

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“…Therefore, BPA affects estrogen receptor functions and also other nuclear hormone receptors (Fenichel et al, 2013). In recent years, exposure to BPA has been associated with a wide range of metabolic, reproductive, cardiovascular and neurological diseases and also with increased incidences of endocrine diseases and endocrine-related cancers (Dunder et al, 2019;Friques et al, 2020;Hafezi and Abdel-Rahman, 2019;Hu et al, 2019;Khan et al, 2019;Piao et al, 2019;Santoro et al, 2019;Shu et al, 2019;Win-Shwe et al, 2019). These effects are mediated by hormonal regulation and metabolic signals, mainly by nuclear receptors, or by mechanisms that are currently unknown.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

et al. 2020

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Bisphenol-A (BPA) used in the production of plastic materials is a temperature-soluble agent. It also has a steroid hormone-like activity; therefore, it poses a danger to human health. In our study, we aimed to investigate the effects of BPA on lymph node and spleen in male rats exposed to this agent during prenatal stage. The pregnant female rats were divided into four groups: control, sham, low dose (300 µg/kg BPA), and high dose (900 µg/kg BPA). BPA was dissolved in 1 mL of corn oil and administered to the pregnant rats every day during pregnancy. On the 21st and 45th day after the birth, male rats’ lymph node and spleen samples were taken and histopathological examination was performed. Samples were stained with hematoxylin and eosin to determine the general histological appearance, and with CD3 and CD20 immunohistochemically. The results of staining were evaluated by H-score, and statistical analysis was performed. In the samples, BPA applications were not found to cause significant tissue damage. But there was a significant decrease in the immunoreactivities of CD3 and CD20 after BPA applications in both 21st and 45th day samples. After high dose BPA administration, decreased CD3 immunoreactivity was statistically significant. It is thought that BPA does not cause histologically significant tissue damage, but it may impair organ function at cellular level. The investigation of molecules involved in organ function will be useful in revealing the mechanisms that will cause dysfunction.

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Bisphenol A, Chlorinated Derivatives of Bisphenol A and Occurrence of Myocardial Infarction in Patients with Type 2 Diabetes: Nested Case-Control Studies in Two European Cohorts

Cited by 38 publications

References 45 publications

The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

The Bisphenol F and Bisphenol S and Cardiovascular disease: results from NHANES 2013-2016

Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review

Investigation of the effects of bisphenol-A exposure on lymphoid system in prenatal stage

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