Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC–MS/MS

Frederiksen, Hanne; Aksglæde, Lise; Sørensen, Kaspar; Nielsen, O.B.; Main, Katharina M.; Skakkebæk, Niels E.; Juul, Anders; Andersson, Anna‐Maria

doi:10.1016/j.ijheh.2013.01.007

Cited by 130 publications

(80 citation statements)

References 47 publications

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“…However, it was much lower than other countries. The median excretion dose of BP-3 by Danish adolescents was 57.9 ng/kg-bw/day (boys: 50.4 ng/kg-bw/day; girls: 83.2 ng/kg-bw/day), which was 4 times higher than those in the present study (Frederiksen et al, 2013a). Based on the median concentration of BP-3 of 18.0 ng/mL reported by the NHANES (Calafat et al, 2008), and a body weight of 80.0 kg for American adults as reported by the U.S. EPA (EPA, 2011), the excretion dose for BP-3 by the U.S. adults were 382 ng/kg-bw/day, which was 27 times higher than those for Chinese young adults.…”

Section: Daily Excretion Dosecontrasting

confidence: 80%

“…The 2003e2004 National Health and Nutrition Examination Survey (NHANES) conducted by the U.S. Centers for Disease Control and Prevention (CDC) found that BP-3 was found in over 97% of urine samples from the U.S. general population (Calafat et al, 2008). A study on Danish children and adolescents also showed that BP-3 was detected in 98.4% of the urine samples (Frederiksen et al, 2013a). In France, 80.5% of 191 urine from pregnant women had BP-3 exposure (Philippat et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Benzonphenone-type UV filters in urine of Chinese young adults: Concentration, source and exposure

Gao

Liu

et al. 2015

Environmental Pollution

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Section: Daily Excretion Dosecontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Benzonphenone-type UV filters in urine of Chinese young adults: Concentration, source and exposure

Gao

Liu

et al. 2015

Environmental Pollution

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“…When arriving at the laboratory, the containers were split into smaller tubes and stored at − 20° or − 80° until analysis. The analysis of 15 different phthalate metabolites, seven parabens and nine phenols were performed at the department of Growth and Reproduction at the University Hospital of Copenhagen (12,22). The measurement of cotinine and creatinine were performed at the Department of Environmental Medicine at the University of Southern Denmark.…”

Section: Sampling and Biomarker Analysismentioning

confidence: 99%

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Knudsen

Hansen

Mizrak

et al. 2017

Reviews on Environmental Health

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AbstractBackground:The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6–11 years and their mothers from rural and urban areas in autumn 2011. Some – but not all – results were published; however, the concurrence of the chemicals has not been assessed.Methods:The measured concentrations of polybrominated diphenyl ethers (PBDEs) and glyphosate is assessed to complete the investigation of all 66 chemicals in DEMOCOPHES. The concentrations of PBDEs were measured in plasma samples of 143 mothers and 116 children. Glyphosate was measured in a subsample of 27 urine samples. Previously assessed chemicals were polychlorinated biphenyls (PCBs), and polyfluoroalkyl substances (PFASs) analyzed in blood samples, mercury analyzed in hair, and phthalate metabolites, parabens, phenols, cadmium, paracetamol and cotinine analyzed in urine samples. Differences in concentrations between mothers and children were assessed, and the associations between the concentrations of the different environmental chemicals. investigated by correlation analysis.Results:PBDE47 was found in relatively high levels compared with previous Danish results in both mothers and children, with a significantly higher level in the children compared to their mothers. Glyphosate in concentrations around 1 ng/mL was detected in all 27 samples. The analyzed environmental exposures seem to follow a pattern where chemicals within the same classes are strongly correlated and where children and mothers are exposed to the same chemicals.Conclusion:The correlations between the measured environmental chemicals indicate that a specific exposure pattern may exist, where people who are highly exposed to one class of environmental chemicals also may be highly exposed to certain other classes. As some of the compounds were measured in higher levels in children compared to mothers, increased focus also on the exposure in young children is recommended. For more detailed investigation of specific exposure sources more studies with increased power and detailed questionnaires should be developed.

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“…In women, the maximum concentration was 122.8 μg/g creatinine, i.e., over 3.5 times higher, compared to the highest concentration indicated in children, which was 33.3 μg/g creatinine. Among children and adolescents aged 6-21, Frederiksen et al (2013) [85] examined 129 participants of the "Copenhagen puberty study from 2006 to 2008." The average concentration of BPA determined in the urine was 1.37 ng/ml.…”

Section: Absorption and Distributionmentioning

confidence: 99%

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Mikołajewska¹,

Stragierowicz²,

Gromadzińska³

2015

Int J Occup Med Environ Health

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Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular. Extensive use of BPA in manufacturing products that come in contact with food increases the risk of exposure to this compound, mainly through the digestive tract. Literature data indicate that exposure to bisphenol A even at low doses may result in adverse health effects. The greatest exposure to BPA is estimated among infants, children and pregnant women. The aim of this review is to show potential sources of exposure to bisphenol A and the adverse health effects caused by exposure to this compound in the group of particular risk.

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Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC–MS/MS

Cited by 130 publications

References 47 publications

Benzonphenone-type UV filters in urine of Chinese young adults: Concentration, source and exposure

Benzonphenone-type UV filters in urine of Chinese young adults: Concentration, source and exposure

Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

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