Biomonitoring of Danish school children and mothers including biomarkers of PBDE and glyphosate

Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background:</jats:title><jats:p>The Danish part of the large European Human biomonitoring pilot project Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale (DEMOCOPHES) investigated the urine, hair and blood concentrations of 66 different environmental chemicals in a group of 145 Danish school children aged 6–11 years and their mothers from rural and urban areas in autumn 2011. Some – but not all – results were published; however, the concurrence of the chemicals has not been assessed.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>The measured concentrations of polybrominated diphenyl ethers (PBDEs) and glyphosate is assessed to complete the investigation of all 66 chemicals in DEMOCOPHES. The concentrations of PBDEs were measured in plasma samples of 143 mothers and 116 children. Glyphosate was measured in a subsample of 27 urine samples. Previously assessed chemicals were polychlorinated biphenyls (PCBs), and polyfluoroalkyl substances (PFASs) analyzed in blood samples, mercury analyzed in hair, and phthalate metabolites, parabens, phenols, cadmium, paracetamol and cotinine analyzed in urine samples. Differences in concentrations between mothers and children were assessed, and the associations between the concentrations of the different environmental chemicals. investigated by correlation analysis.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>PBDE47 was found in relatively high levels compared with previous Danish results in both mothers and children, with a significantly higher level in the children compared to their mothers. Glyphosate in concentrations around 1 ng/mL was detected in all 27 samples. The analyzed environmental exposures seem to follow a pattern where chemicals within the same classes are strongly correlated and where children and mothers are exposed to the same chemicals.</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>The correlations between the measured environmental chemicals indicate that a specific exposure pattern may exist, where people who are highly exposed to one class of environmental chemicals also may be highly exposed to certain other classes. As some of the compounds were measured in higher levels in children compared to mothers, increased focus also on the exposure in young children is recommended. For more detailed investigation of specific exposure sources more studies with increased power and detailed questionnaires should be developed.</jats:p></jats:sec>

Re-registration Challenges of Glyphosate in the European Union

“…Nonetheless, glyphosate residues were reported in bottled drinking water (Rendón-von Osten and Dzul-Caamal, 2017). Glyphosate residues were detected in honey and soy sauce (Rubio et al, 2014), in produce (Bøhn et al, 2014), processed food products, even in human specimens (blood, urine, mother's milk) (Knudsen et al, 2017;Rendón-von Osten and Dzul-Caamal, 2017). It should be noted, however, that measurements of glyphosate in complex biological matrices e.g., blood and breast milk, that led to positive scores used ELISA methods of questionable accuracy, and instrumental analysis by LC-MS/MS did not find glyphosate above its limit of detection in human breast milk (McGuire et al, 2016;Steinborn et al, 2016).…”

Human Biomonitoring of Glyphosate Exposures: State-of-the-Art and Future Research Challenges

“…A paucity of data exists regarding glyphosate exposure levels in potentially exposed (sub)populations in occupational and environmental settings and among different family types, e.g., studies focusing on residential, para-occupational, and environmental exposures. This is especially important for vulnerable populations such as children, who have already been shown to exhibit higher levels of glyphosate body burdens than adults [ 23 , 24 ].…”

Glyphosate and AMPA levels in human urine samples and their correlation with food consumption: results of the cross-sectional KarMeN study in Germany

“…With regard to studies from additional countries dealing with human exposure to glyphosate, we refer to the current review of Gillezeau et al (2019). This review listed three studies investigating the association between glyphosate/AMPA exposure and food consumption or dietary pattern in the general population (no occupational exposure) (Knudsen et al 2017;McGuire et al 2016;Parvez et al 2018). The number of participants in these three studies was between 27 and 71, and one of the studies (McGuire et al 2016) only examined the differences in urinary glyphosate and AMPA concentrations between subjects consuming organic and conventionally grown food.…”