Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment

Krawczyk, Barbara

doi:10.1016/j.chemosphere.2023.137763

Cited by 65 publications

(24 citation statements)

References 206 publications

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“…Moreover, the octanol−water partition coefficient (K ow ) serves as an indicator of hydrophobicity and is effective in estimating biological availability. 54 The estimated log(K ow ) values for BPA, BPAF, and BPG were 3.64, 4.67, and 6.56, respectively, 55 consistent with their enrichment level in larvae and observed behavioral and neurotransmission effects in this work. Consequently, the high lipophilicity of BPG makes it more likely to accumulate in the brain, partially explaining its pronounced neural impact in the present study.…”

Section: Analogues Represent a Greater Neuroendocrinesupporting

confidence: 85%

Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut–Brain Regulation in Zebrafish

Mu,

Liu,

Zhao

et al. 2024

Environ. Sci. Technol.

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There is epidemiological evidence in humans that exposure to endocrine-disrupting chemicals such as bisphenol A (BPA) is tied to abnormal neuroendocrine function with both behavioral and intestinal symptoms. However, the underlying mechanism of this effect, particularly the role of gut−brain regulation, is poorly understood. We exposed zebrafish embryos to a concentration series (including environmentally relevant levels) of BPA and its analogues. The analogue bisphenol G (BPG) yielded the strongest behavioral impact on zebrafish larvae and inhibited the largest number of neurotransmitters, with an effective concentration of 0.5 μg/L, followed by bisphenol AF (BPAF) and BPA. In neurod1:EGFP transgenic zebrafish, BPG and BPAF inhibited the distribution of enteroendocrine cells (EECs), which is associated with decreased neurotransmitters level and behavioral activity. Immune staining of ace-α-tubulin suggested that BPAF inhibited vagal neural development at 50 and 500 μg/L. Single-cell RNA-Seq demonstrated that BPG disrupted the neuroendocrine system by inducing inflammatory responses in intestinal epithelial cells via TNFα-trypsin-EEC signaling. BPAF exposure activated apoptosis and inhibited neural developmental pathways in vagal neurons, consistent with immunofluorescence imaging studies. These findings show that both BPG and BPAF affect the neuroendocrine system through the gut−brain axis but by different mechanisms, revealing new insights into the modes of bisphenol-mediated neuroendocrine disruption.

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Section: Analogues Represent a Greater Neuroendocrinesupporting

confidence: 85%

Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut–Brain Regulation in Zebrafish

Mu,

Liu,

Zhao

et al. 2024

Environ. Sci. Technol.

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“…BPA is a compound with the molecular formula C 15 H 16 O 2 . In industry, BPA is used to synthesize polycarbonate and epoxy resin, as well as in the inner coating of food and beverage (milk powder) cans (Czarny‐Krzymińska et al., 2023), food packaging (Figure 2) (Sungur et al., 2014), medical devices, and dental sealants (Kang et al., 2006). Highly heterogeneous, BPA belongs to the family of endocrine disruptors (Diamanti‐Kandarakis et al., 2009).…”

Section: Influence Of Anthocyanins On Food Contaminants From the Natu...mentioning

confidence: 99%

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

Jiang,

Li,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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Foodborne contaminants refer to substances that are present in food and threaten food safety. Due to the progress in detection technology and the rising concerns regarding public health, there has been a surge in research focusing on the dangers posed by foodborne contaminants. These studies aim to explore and implement strategies that are both safe and efficient in mitigating the associated risks. Anthocyanins, a class of flavonoids, are abundantly present in various plant species, such as blueberries, grapes, purple sweet potatoes, cherries, mulberries, and others. Numerous epidemiological and nutritional intervention studies have provided evidence indicating that the consumption of anthocyanins through dietary intake offers a range of protective effects against the detrimental impact of foodborne contaminants. The present study aims to differentiate between two distinct subclasses of foodborne contaminants: those that are generated during the processing of food and those that originate from the surrounding environment. Furthermore, the impact of anthocyanins on foodborne contaminants was also summarized based on a review of articles published within the last 10 years. However, further investigation is warranted regarding the mechanism by which anthocyanins target foodborne contaminants, as well as the potential impact of individual variations in response. Additionally, it is important to note that there is currently a dearth of clinical research examining the efficacy of anthocyanins as an intervention for mitigating the effects of foodborne pollutants. Thus, by exploring the detoxification effect and mechanism of anthocyanins on foodborne pollutants, this review thereby provides evidence, supporting the utilization of anthocyanin‐rich diets as a means to mitigate the detrimental effects of foodborne contaminants.

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“…However, numerous studies have shown that exposure to BPA can causes adverse effects on reproduction, neurobehavior, obesity, cardiovascular development, liver function, oxidative stress, and inflammation. − As a result, its use has been restricted in several products. In response to these regulations, bisphenol analogues (BPs) such as bisphenol AF (BPAF), bisphenol F (BPF), bisphenol S (BPS), and bisphenol AP (BPAP) have been developed as substitutes for BPA . As a consequence, these BPs were detected in environment and consumer products, attracting widespread attention …”

Section: Introductionmentioning

confidence: 99%

Bisphenol AP Exposure-Induced Inflammatory Response in Zebrafish Embryos Revealed by Transcriptomic Analysis

Ding,

Wang

2024

Environ. Health

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Bisphenol AP (BPAP) is a bisphenol analogue that is used as a substitute for BPA in industrial production and is now commonly found in the environment. Currently, there is limited information available on its developmental toxicity in aquatic organisms. This study exploited zebrafish embryos to investigate the adverse effects of BPAP exposure during their early life stages. The results revealed that BPAP had a median lethal concentration (LC 50 ) of 36, 22, and 8.5 μmol/L for zebrafish embryos at 24, 48, and 72 h post fertilization (hpf), respectively. Additionally, exposure to BPAP led to abnormal development in zebrafish embryos, including hatching delay, malformation, and inhibition of spontaneous movements. Transcriptomic analysis further revealed that BPAP exposure upregulated the mRNA expression levels of genes related to inflammatory pathways, such as il1b, ptgs2b, and fosab, indicating the induction of an inflammatory response. Overall, our findings provide early and valuable insights into the environmental and health risks associated with BPAP exposure.

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Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment

Cited by 65 publications

References 206 publications

Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut–Brain Regulation in Zebrafish

Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut–Brain Regulation in Zebrafish

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

Bisphenol AP Exposure-Induced Inflammatory Response in Zebrafish Embryos Revealed by Transcriptomic Analysis

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