Bisphenol A and cardiometabolic risk factors in obese children

Khalil, Naila; Ebert, James R.; Wang, Lei; Belcher, Scott M.; Lee, Miryoung; Czerwinski, Stefan A.; Kannan, Kurunthachalam

doi:10.1016/j.scitotenv.2013.09.088

Cited by 91 publications

(62 citation statements)

References 47 publications

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“…It was reported that increased urinary levels of BPA were associated with increased aspartate amino transferase, elevated diastolic blood pressure and increased insulin resistance. 30 There are a limited number of studies about the effects of BPA on autism which were investigated together with exposure to other toxins. In 2010, in a study investigating the effects of exposure to environmental toxins including BPA on autism spectrum disorder, it was found the that mothers of children with autism spectrum disorder had more limited information about environmental toxins and they were exposed to these toxins more than those of healthy children.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

et al. 2015

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The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 µg/ml, 2.70 ± 0.90 µg/ml, 1.25 ± 0.30 ng/ml) compared to healthy control subjects (0.29 ± 0.05 µg/ml, 1.62 ± 0.56 µg/ml, 0.88 ± 0.18 ng/ml) respectively (P = .000). The fact that higher serum MEHP, DEHP, and BPA were found levels in the autism spectrum disorder group compared to healthy controls suggests that endocrine disruptors may have a role in the pathogenesis of autism spectrum disorders.

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Section: Discussionmentioning

confidence: 99%

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

et al. 2015

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“…While the majority of the epidemiological studies of BPA and obesity demonstrate a positive association (vom Saal & Hughes 2005, Khalil et al . 2013, Rochester 2013), molecular studies in vitro (Chamorro-Garcia et al .…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A enhances adipogenic differentiation of human adipose stromal/stem cells

Ohlstein¹,

Strong²,

McLachlan³

et al. 2014

Journal of Molecular Endocrinology

112

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Exposure of humans to the endocrine disrupter bisphenol A (BPA) has been associated with increased weight and obesity. However, the mechanism(s) by which BPA increases adipose tissue in humans remains to be determined. The goal of this study was to determine the effects of BPA on adipogenesis of cultured human adipose stromal/stem cells (ASCs), precursors to mature adipocytes. ASCs from three donors were cultured for either 14 or 21 days in adipogenic differentiation media containing increasing concentrations of BPA (100 pM–10 μM). The extent of adipogenic differentiation in the ASCs was assessed by staining with Oil Red O to visualize adipogenic differentiation and then quantified by extraction and optical density measurement of the retained dye. BPA significantly enhanced adipogenesis at a concentration of 1 μM after 21 days of culture. Additionally, we found that BPA increased transcription of the estrogen receptor (ER (ESR1)) and that treatment with the ER antagonist ICI 182 780, blocked the effects of BPA, indicating that BPA may act via an ER-mediated pathway. The results of molecular analyses indicated that the expression of the adipogenesis-associated genes dual leucine zipper-bearing kinase (DLK (MAP3K12)), IGF1, CCAAT/enhancer-binding protein alpha (C/EBPα (CEBPA)), peroxisome proliferator-activated receptor gamma (PPARγ (PPARG)), and lipoprotein lipase (LPL) was temporally accelerated and increased by BPA. In summary, these results indicate that BPA significantly enhances adipogenesis in ASCs through an ER-mediated pathway at physiologically relevant concentrations.

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“…However, no such correlation was observed when urinary concentration was specified in terms of mg BPA/g creatinine. Khalil et al (2014) [103] found that higher concentrations of BPA in the urine collected from 39 obese and overweight children (3-8 years, Children's Medical Center of Dayton, Ohio) were associated with adverse metabolic effects, and also with elevated diastolic blood pressure levels.…”

Section: Children's Development Birth Weightmentioning

confidence: 99%

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

Mikołajewska¹,

Stragierowicz²,

Gromadzińska³

2015

Int J Occup Med Environ Health

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Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular. Extensive use of BPA in manufacturing products that come in contact with food increases the risk of exposure to this compound, mainly through the digestive tract. Literature data indicate that exposure to bisphenol A even at low doses may result in adverse health effects. The greatest exposure to BPA is estimated among infants, children and pregnant women. The aim of this review is to show potential sources of exposure to bisphenol A and the adverse health effects caused by exposure to this compound in the group of particular risk.

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Bisphenol A and cardiometabolic risk factors in obese children

Cited by 91 publications

References 47 publications

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder

Bisphenol A enhances adipogenic differentiation of human adipose stromal/stem cells

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

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