Bisphenol A Accumulation in the Freshwater Clam Pisidium amnicum at Low Temperatures

Heinonen, Jari; Honkanen, Jani O.; Kukkonen, Jussi V. K.; Holopainen, Ismo J.

doi:10.1007/s00244-002-1146-y

Cited by 48 publications

(23 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In adult organisms, BPA is known to affect components involved in the maintenance of the redox status by downregulating the expression of antioxidant genes. [40] The results support the view that UV based advanced oxidation processes can effectively convert BPA into inactive byproducts. UV treatment of BPA resulted in a reduction in toxicity by reducing mortality of zebrafish embryos.…”

Section: Discussionsupporting

confidence: 81%

Efficacy of UV-C photolysis of bisphenol A on transcriptome alterations of genes in zebrafish embryos

Saeed

Hashmi

Zare

et al. 2016

Journal of Environmental Science and Health, Part A

View full text Add to dashboard Cite

The purpose of this study was to investigate the efficacy of UV-C direct photolysis of bisphenol A (BPA) as a remediation method of BPA contamination. We used zebrafish embryos as a model organism to test the toxicity and residual biological activity by measuring cytochrome P4501A1 (CYP1A), aromatase B (Aro B) and heat shock proteins (HSP-70) transcript levels. The mRNA levels of CYP1A gene increased about two fold while exposure of zebrafish embryos at 72 hpf resulted in significant induction (P = 0.048) of Aro B at 100 µg/L of BPA. Exposure of zebrafish embryos at 72 hpf to increasing concentrations of BPA resulted in significant induction (P = 0.0031) of HSP-70 transcript level. UV treatment of BPA resulted in a significant reduction in toxicity by reducing mortality of zebrafish embryos. The results suggest that UV-C direct photolysis may be an effective method for remediation of BPA contamination. Further studies will be necessary for better understanding of the identity and relative activity of the UV degradation by-products.

show abstract

Section: Discussionsupporting

confidence: 81%

Efficacy of UV-C photolysis of bisphenol A on transcriptome alterations of genes in zebrafish embryos

Saeed

Hashmi

Zare

et al. 2016

Journal of Environmental Science and Health, Part A

View full text Add to dashboard Cite

show abstract

“…In addition, net elimination of bisphenol A may be more efficient at high temperatures, especially within the optimal temperature regime, as has been shown in freshwater clam [11], but not above the optimal temperature regime in developing salmon embryos [12]. In addition, net elimination of bisphenol A may be more efficient at high temperatures, especially within the optimal temperature regime, as has been shown in freshwater clam [11], but not above the optimal temperature regime in developing salmon embryos [12].…”

Section: Discussionmentioning

confidence: 85%

Environmental temperature changes uptake rate and bioconcentration factors of bisphenol A in tadpoles of Rana Temporaria

Honkanen

Kukkonen

2006

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Toxicokinetics of radiolabeled (14C) bisphenol A was studied in the common frog (Rana temporaria) at two experimental temperatures (7 and 19 degrees C). The growth rate of the tadpoles during the 96-h experiment was very slow at 7 degrees C, but the weight of tadpoles almost tripled at 19 degrees C. At all tested exposure concentrations (0.2, 1.5, 10, and 100 microg/L), conditional uptake rate constants (ku) were 69 to 82%, and elimination rates (ke) 79 to 90% lower, at 7 degrees C than at 19 degrees C. On the contrary, bioconcentration factors (BCFs) were higher at 7 degrees C than at 19 degrees C. Total accumulated bisphenol A per individual was higher at 19 degrees C, which is in agreement with higher k, at 19 degrees C. Exposure concentrations did not have any constant effect on BCFs at the two temperatures. The results of the current experiment suggest that higher temperature increases uptake and total amount of chemical in frog tadpoles but does not necessarily lead to higher BCFs. High temperature may have increased the growth rate more than the uptake rate, resulting in a net dilution of bisphenol A in tadpole tissues. The observed difference in BCFs also could be a result of temperature-induced changes in allometric relationships (increased surface area to volume ratio) and/or more effective elimination in more developed tadpoles at high temperature.

show abstract

“…BPA also stimulated the activity of the phase II enzyme GST, this suggesting that some metabolism of BPA may occur by this route in the hepatopancreas. BPA bioaccumulation and clearance have been demonstrated in bivalves, with shorter half-lives at higher temperatures (Heinonen et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas

Canesi

Borghi

Ciacci

et al. 2007

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A c c e p t e d M a n u s c r i p t A c c e p t e d M a n u s c r i p t 2 AbstractBisphenol A (BPA) is a well-known xenoestrogen in mammalian systems that can affect reproduction also in aquatic organisms. In this work the possible effects of BPA were investigated in the hepatopancreas of the bivalve mollusc Mytilus galloprovincialis: mussels were injected with different amounts of BPA (3-60 ng/g dw tissue) and tissues sampled at 24 h post-injection. Overall, these data indicate that BPA, at environmentally relevant concentrations, can have both estrogen-like and distinct effects in invertebrates like in vertebrates. Expression of different

show abstract

Bisphenol A Accumulation in the Freshwater Clam Pisidium amnicum at Low Temperatures

Cited by 48 publications

References 19 publications

Efficacy of UV-C photolysis of bisphenol A on transcriptome alterations of genes in zebrafish embryos

Efficacy of UV-C photolysis of bisphenol A on transcriptome alterations of genes in zebrafish embryos

Environmental temperature changes uptake rate and bioconcentration factors of bisphenol A in tadpoles of Rana Temporaria

Bisphenol-A alters gene expression and functional parameters in molluscan hepatopancreas

Contact Info

Product

Resources

About