Bispectral EEG (BSEEG) quantifying neuro-inflammation in mice induced by systemic inflammation: A potential mouse model of delirium

Yamanashi, Takehiko; Malicoat, Johnny R.; Steffen, Kalvon T.; Zarei, Kasra; Li, Rui; Purnell, Benton S.; Najafi, Annice; Saito, Kenji; Singh, Uday; Toth, Brandon A.; Lee, Shelley; Dailey, Michael E.; Cui, Huxing; Kaneko, Koichi; Cho, Hyunkeun Ryan; Iwata, Masaaki; Buchanan, Gordon F.; Shinozaki, Gen

doi:10.1016/j.jpsychires.2020.12.036

Cited by 15 publications

(18 citation statements)

References 55 publications

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“…In fact, our group recently developed a pre-clinical model to assess neuroinflammation measured by BSEEG method applied to a mouse in response to systemic inflammation induced by lipopolysaccharides. 23 The model showed clear dose-dependent increase of BSEEG proportionate to dose of lipopolysaccharides and the effect was more drastic in aged mouse compared to young mouse. 23 We speculate that is why the BSEEG is capable to predict patients’ mortality.…”

Section: Discussionmentioning

confidence: 88%

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Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Saito

Malicoat

Leyden

et al. 2021

Brain Communications

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Complications of delirium and dementia increase mortality; however, it is difficult to diagnose delirium accurately, especially among dementia patients. The bispectral electroencephalography (BSEEG) score can detect delirium and predict mortality in elderly patients. We aimed to develop an efficient and reliable BSEEG device for high-throughput screening. We also hypothesized that BSEEG score can predict mortality among dementia patients. A prospective cohort study was conducted between January 2016 to December 2018 to measure BSEEG from elderly patients and correlate with outcomes. A total of 502 elderly (55 years old or older) patients with and without dementia were enrolled. For a replication of the utility of BSEEG, mortalities between BSEEG-positive and BSEEG-negative group were compared. In addition, patients with and without dementia status was added to examine the utility of BSEEG among dementia patients. The mortality within 180 days in the BSEEG-positive group was higher than that of the BSEEG-negative group in both the replication and the total cohorts. Mortality of those in the BSEEG-positive group showed a dose-dependent increase in both cohorts. When the dementia patients showed BSEEG positive, their mortality was significantly higher than those with dementia but who were BSEEG-negative. Mortality within 30 days in the BSEEG-positive group was significantly higher than that of the BSEEG-negative group. The utility of the BSEEG to predict mortality among large sample of 502 elderly patients was shown. The BSEEG score can predict mortality among elderly patients in general, and even among dementia patients, as soon as 30 days.

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Section: Discussionmentioning

confidence: 88%

“… 23 The model showed clear dose-dependent increase of BSEEG proportionate to dose of lipopolysaccharides and the effect was more drastic in aged mouse compared to young mouse. 23 We speculate that is why the BSEEG is capable to predict patients’ mortality.…”

Section: Discussionmentioning

confidence: 88%

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Saito

Malicoat

Leyden

et al. 2021

Brain Communications

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“…Our previous studies showed that the BSEEG approach can detect delirium subjects 13 , 15 , 16 and predict poor outcomes 14 . It has also been shown that increased BSEEG score was observed in lipopolysaccharides-induced delirium mouse model 23 . The BSEEG approach presented here is an objective marker of brain dysfunction, as it indicates more slow waves compared to high-frequency waves.…”

Section: Discussionmentioning

confidence: 94%

Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score

Yamanashi

Marra

Crutchley

et al. 2021

Sci Rep

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We have previously developed a bispectral electroencephalography (BSEEG) device, which was shown to be effective in detecting delirium and predicting patient outcomes. In this study we aimed to apply the BSEEG approach for a sepsis. This was a retrospective cohort study conducted at a single center. Sepsis-positive cases were identified based on retrospective chart review. EEG raw data and calculated BSEEG scores were obtained in the previous studies. The relationship between BSEEG scores and sepsis was analyzed, as well as the relationship among sepsis, BSEEG score, and mortality. Data were analyzed from 628 patients. The BSEEG score from the first encounter (1st BSEEG) showed a significant difference between patients with and without sepsis (p = 0.0062), although AUC was very small indicating that it is not suitable for detection purpose. Sepsis patients with high BSEEG scores showed the highest mortality, and non-sepsis patients with low BSEEG scores showed the lowest mortality. Mortality of non-sepsis patients with high BSEEG scores was as bad as that of sepsis patients with low BSEEG scores. Even adjusting for age, gender, comorbidity, and sepsis status, BSEEG remained a significant predictor of mortality (p = 0.008). These data are demonstrating its usefulness as a potential tool for identification of patients at high risk and management of sepsis.

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“…Neurodegeneration can result from the alterations in the balance of neurotransmitters (Arai et al, 2004;Harris et al, 2014;Kim et al, 2020;Korte-Bouws et al, 2018;Tyagi et al, 2008;Vakalopoulos, 2014). Inflammation was previously reported to alter the neurotransmitter metabolism, and thus affects frontal neuronal activity (Yamanashi et al, 2021). In our study the combination of BAY-117082 and MOR/GAL synergistically decreased glutamate, whether this synergistic effect exists between BAY-117082 and MOR/GAL on other neurotransmitters need further investigation.…”

Section: Discussionmentioning

confidence: 50%

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Magdy

Gamal

Samir

et al. 2021

Journal Cellular Physiology

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Inflammatory pathway and disruption in glutamate homeostasis join at the level of the glia, resulting in various neurological disorders. In vitro studies have provided evidence that membrane proteins connexions (Cxs) are involved in glutamate release, meanwhile, excitatory amino-acid transporters (EAATs) are crucial for glutamate reuptake (clearance). Moreover, pannexin-1 (Panx-1) activation is more detrimental to neurons. Their expression patterns during inflammation and the impacts of IκB kinase (IKK) inhibition, morphine, and galantamine on the inflammatory-associated glutamate imbalance remain elusive.To investigate this, rats were injected with saline or lipopolysaccharide.Thereafter, vehicles, morphine, galantamine, and BAY-117082 were administered in different groups of animals. Subsequently, electroencephalography, enzyme-linked immunosorbent assay, western blot, and histopathological examinations were carried out and various indicators of inflammation and glutamate level were determined. Parallel analysis of Cxs, Panx-1, and EAAts in the brain was performed. Our findings strengthen the concept that unregulated expressions of Cxs, Panx-1, and EAATs contribute to glutamate accumulation and neuronal cell loss. Nuclear factor-kB (NF-κB) pathway can significantly contribute to glutamate homeostasis via modulating Cxs, Panx-1, and EAATs expressions. BAY-117082, via inhibition of IkK, promoted the antiinflammatory effects of morphine as well as galantamine. We concluded that NF-κB is an important component of reshaping the expressions of Cxs, panx-1, and EAATs and the development of glutamate-induced neuronal degeneration.

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Bispectral EEG (BSEEG) quantifying neuro-inflammation in mice induced by systemic inflammation: A potential mouse model of delirium

Cited by 15 publications

References 55 publications

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Mortality prediction by bispectral electroencephalography among 502 patients: its role in dementia

Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

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