1930
DOI: 10.1001/jama.1930.02720120010004
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Bismuth Subnitrate in the Treatment of Arterial Hypertension

Abstract: tonsils, and also the importance of taking care of the teeth even after the tonsils are taken out. There is unquestionably a swing against the promiscuous removal of tonsils, and I am sure that Dr. Kaiser's work, reported from year to year, is the leading factor in this tremendous revulsion of feeling from too frequent taking out of the tonsils to a proper aspect of the subject. In Cincinnati and vicinity there used to be large groups of children on whom tonsillectomies had been ordered based on the fact that … Show more

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Cited by 20 publications
(7 citation statements)
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“…Stieglitz was aware of evidence from bacteriologists that enteric bacteria could convert nitrate to nitrite (Salen, 1925;Zobell, 1932). He thus proposed the following (Stieglitz, 1927):…”
Section: B Historical Uses Of Inorganic Nitratementioning
confidence: 99%
“…Stieglitz was aware of evidence from bacteriologists that enteric bacteria could convert nitrate to nitrite (Salen, 1925;Zobell, 1932). He thus proposed the following (Stieglitz, 1927):…”
Section: B Historical Uses Of Inorganic Nitratementioning
confidence: 99%
“…Whilst the earliest observation of nitrate supplementation lowering blood pressure dates back to 1927 [ 93 ], it is the more recent observations that have raised the intense interest currently in the possible use of dietary nitrate as an anti-hypertensive. This interest was initiated in 2006 when Larsen et al first demonstrated that a single oral sodium nitrate load of 0.1 mmol/kg/day for 3 days reduces diastolic blood pressure by 3.7 mmHg ( P = 0.002).…”
Section: Clinical Trial Evidencementioning
confidence: 99%
“…Inorganic NO 3 − has been used to treat CVD for over two millennia in traditional Chinese medicines,21 and was used by doctors in the early 20th century with some notable success for hypertension 22. While the doctors at the time were uncertain of the mechanisms of these effects, we now know that the utility of nitrate relates to its ability to provide a source of the pleiotropic molecule nitric oxide (NO).…”
Section: Inorganic No3− and Cvdmentioning
confidence: 99%