Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs

Kim, Sung Hyun; Tramontina, Vinicius Augusto; Papalexiou, Vula; Luczsyzyn, S M; Lima, Antônio Adílson Soares de; Prado, Antonia Maria Binder do

doi:10.1016/j.ijom.2011.12.002

Cited by 15 publications

(17 citation statements)

References 11 publications

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“…However, postoperative complications such as persistent bleeding, pain, paresthesia, and discomfort have been reported following a free gingival graft procedure (2,3). Although different adjunct treatments such as antiseptics, antibacterials (4,5), hemostatic agents (6), and bioactive materials (7) have been tested to overcome these complications and minimize patient discomfort, an ideal treatment has not been found to date. An increased wound healing rate can reduce the potential for infection and discomfort after periodontal plastic surgeries (8).…”

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confidence: 99%

Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Sezgin¹,

Çetin²,

Bulut³

et al. 2019

Balkan Med J

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Background:Postoperative complications occur after periodontal plastic surgeries, but an ideal treatment to overcome them has not been found yet.Aims:To evaluate the effects of topically applied Oral-norm gel on the healing of excisional wounds.Study Design:Animal experiment.Methods:Excisional wounds with a diameter of 3 mm were made in the center of the palatal mucosa of 63 Sprague Dawley rats. Seven animals were sacrificed at time 0. The remaining rats were divided into two groups: a test group in which the topical Oral-norm gel was applied three times a day and a control group in which nothing was applied. Seven animals in each group were sacrificed at 3, 7, 14, and 21 days. Mean wound surface area was measured photographically, while wound healing and width were evaluated microscopically.Results:The mean wound surface area decreased significantly after 3 days in both groups (p<0.001). Between days 3 and 7, the mean wound surface area decreased from 6.62 (2.85) to 0.83 (1.62) mm2 in the control group and 5.07 (0.88) to 1.42 (1.67) mm2 in the test group. The wound width decreased significantly on day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had a significant increase in inflammation and vascularization on day 3 (p<0.001), with a reduction thereafter. No significant differences in macroscopic and microscopic measurements were observed between the groups at any time point (p>0.05).Conclusion:The Oral-norm gel has no positive healing effects in the palatal mucosa of rats.

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confidence: 99%

Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Sezgin¹,

Çetin²,

Bulut³

et al. 2019

Balkan Med J

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“…Although haemostatics (Rossmann & Rees , Kim et al. ), mechanical barriers (Farnoush ), bioactive materials (Carnio & Hallmon , Yen et al. , Shanmugam et al.…”

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confidence: 99%

“…However, paresthesia, herpetic lesion, mucocele, arteriovenous shunt, excessive bleeding (BLE) and severe post-operative pain have been reported following FGG procedure (Brasher et al 1975, Wang et al 2001. Although haemostatics (Rossmann & Rees 1999, Kim et al 2012, mechanical barriers (Farnoush 1978), bioactive materials (Carnio & Hallmon 2005, Yen et al 2007, Shanmugam et al 2010, Ayvazyan et al 2011, Hammad et al 2011, Thoma et al 2012, antibacterial and antiseptic agents (Kozlovsky et al 2007, Hammad et al 2011, Patel et al 2012, herbal products (Hammad et al 2011, Verstappen et al 2012) have been found effective in preventing such complications, an ideal support could not be specified for this purpose. Further, undesired side effects such as delayed wound healing/foreign body reaction (Petersen et al 1984, Finn et al 1992, Matthew et al 1993) have been notified.…”

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confidence: 99%

Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery

Keçeli

Aylıkçı

Köseoğlu

et al. 2015

J Clinic Periodontology

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“…[ 21 ] Good hemostasis has been achieved by using the drug as local hemostatic in tonsillectomy[ 22 ] and in dentistry as topical hemostatic agent at palatal donor sites. [ 23 ] One of its main advantages, particularly in underdeveloped or developing countries, is its low cost. BS appears to be as effective as FTA in preventing postextraction hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial comparing three local hemostatic agents for dental extractions in patients under chronic anticoagulant therapy - A comparative study

Puia

Hilber

Garcia-Blanco

2020

Ann Maxillofac Surg

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Introduction: Oral anticoagulants are widely used worldwide for many systemic diseases. Recent oral surgical protocols suggest that therapeutic levels of the anticoagulant drug should be maintained for simple dental extractions because bleeding complications could be managed with proper local hemostasis. The aim of the present study was to compare bleeding complication of three different local hemostatic agents for dental extractions without interrupting drug administration in patients undergoing oral Vitamin K antagonist chronic anticoagulant therapy. Material and Methods: Randomized control trial of three hemostatic agents for dental extractions, in patients under oral anticoagulant therapy without drug interruption. The present study included 240 patients with international normalized ratio between 1.5 and 3.5. Patients took their anticoagulation drug normally. A single surgeon performed calibrated simple dental extractions and applied a plug of bismuth subgallate (BS), fibrin tissue adhesive (FTA) or microfibrillar collagen (MC), assigned randomly. Statistical analysis of bleeding between the groups was performed using the Chi-square test. Results: There was no hemorrhagic complication in the BS group, and only one in the FTA group. However, in the MC group, 10 patients (12.5%) suffered postoperative bleeding. Data analysis showed statistical differences between the MC group and the other two groups ( P < 0.05). Discussion: BS and FTA showed similar clinical effectiveness and were more effective than MC for the control of postoperative bleeding in oral anticoagulated patients.

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Bismuth subgallate as a topical haemostatic agent at the palatal wounds: a histologic study in dogs

Cited by 15 publications

References 11 publications

Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery

Randomized clinical trial comparing three local hemostatic agents for dental extractions in patients under chronic anticoagulant therapy - A comparative study

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