Bismuth (III) Acetate: A New Catalyst for Preparation of Azlactones via the Erlenmeyer Synthesis

Catalyzing the Erlenmeyer Plöchl reaction: organic bases versus sodium acetate

“…1,[5][6][7][8][9][10][11][12][13][14][15] The conditions reported in several of them 8,14,15 have been tested for the synthesis of compound 1; however, these produced incomplete reactions and/or an unacceptable amount of transacylation by-products. 16 Although sodium acetate provided satisfactory conversion to compound 1, long reaction time (24 h) and other scale up factors such as agitation and large a excess of sodium acetate led us to evaluate alternative organic bases.…”

A Facile and Efficient Synthesis of 4‐Arylidene‐2‐phenyl‐5(4H)‐oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens

“…Because of the diverse pharmacological and other applications, synthesis of 4‐arylidene‐2‐phenyl‐5(4 H )‐oxazolones has been of utmost interest to organic chemists for a long time. A number of methods are available for the synthesis of 5(4 H )‐oxazolones, including the recent use of bismuth acetate and zinc chloride…”

“…[1][2][3][4][5][6] Because of the diverse pharmacological and other applications, 7 synthesis of 4-arylidene-2-phenyl-5 (4H)-oxazolones has been of utmost interest to organic chemists for a long time. A number of methods 8 are available for the synthesis of 5(4H)-oxazolones, including the recent use of bismuth acetate 9 and zinc chloride. 10 Further, microwave-assisted synthesis of these compounds 11 was found to be clearer, faster, and more economical.…”

Diammonium hydrogen phosphate: a versatile and inexpensive reagent for one-pot synthesis of dihydropyrimidinones, quinazolinones and azalactones under solvent-free conditions

“…They are also useful precursors for the synthesis of amino acids [29], peptides [30], heterocycles [31], biosensors [32], and antitumor or antimicrobial compounds [33]. The Erlenmeyer reaction is the most widely used method for the preparation of these compounds [34], and various reagents are known to effect this condensation [35][36][37][38][39][40][41]. Some of these methods, however, suffer from drawbacks, which include the use of hazardous materials [39], commercially non-available [37] or highly corrosive and difficult-to-handle reagents [36], long reaction times [34], low yields [38], drastic reaction conditions and tedious workup procedures [39][40][41].…”