Bismuth-Based Quadruple Therapy with Bismuth Subcitrate, Metronidazole, Tetracycline and Omeprazole in the Eradication ofHelicobacter pylori

Abstract

The OBMT regimen used in this study is safe and effective against metronidazole-sensitive H pylori strains.

Efficacy and safety of single‐triple capsules of bismuth biskalcitrate, metronidazole and tetracycline, given with omeprazole, for the eradication of Helicobacter pylori: an international multicentre study

“…21 This treatment, when given for 10 days, appears to contain the appropriate combination of ingredients to overcome metronidazole resistance, a shortcoming of other bismuth-based combinations used previously. 20 It was also found that the eradication rate of H. pylori did not differ by disease type, as duodenal ulcer, gastric ulcer and non-ulcer dyspepsia all showed greater than 90% eradication rates; this supports the work of others, who also showed no discernible differences by disease type when patients were treated with omeprazolebismuth biskalcitrate-metronidazole-tetracycline. 22 The small number of patients treated in some of these categories in the current trial, however, requires caution in interpreting these results.…”

“…This regimen was selected for development based on effectiveness, treatment duration, patient convenience, safety and cost. [16][17][18][19][20] The 'three-in-one' feature of this capsule was designed to increase acceptability and compliance, as the patient would need to take three of the four medications from the same bottle at the same times. This study was designed to assess the efficacy and safety of this regimen for the eradication of H. pylori.…”

Triple Antimicrobial Therapy and Acid Suppression in Dogs with Chronic Vomiting and Gastric Helicobacter spp

“…When clinical signs develop during adulthood in humans infected with H pylori, they are preceded by a long asymptomatic period, during which progressive gastric structural and functional damage occurs. 5,47,48 The frequency of vomiting in these dogs may increase as progressive gastritis develops. A longer study period is needed to address this question.…”

Treatment of H. pylori Infection: A Review

“…In the last years, however, the decrease of eradication rate of the standard triple therapy based on amoxicillin, clarithromycin plus a PPI, and the increasing prevalence of metronidazole or clarithromycin resistant strains have induced several authors to propose the quadruple therapy -based on metronidazole, tetracycline Fig (7), bismuth compounds and a PPI or ranitidine-even as first line option [76][77][78][79][80][81][82][83][84][85][86][87][88][89]. In literature several protocols are reported, decribing treatments lasting 7, 10 or 14 days, with different dosages of metronidazole, bismuth, tetracycline and PPI.…”