Biscoumarin: new class of urease inhibitors; economical synthesis and activity

A Novel Synthesis of Biscoumarin Derivatives Catalyzed by ZnCl2 under Solvent-Free Coditions

“…IR spectra were measured on a Shimadzu IR-470 Spectrophotometer. 1 H NMR spectra were determined on Bruker400 DRX AVANCE instrument at 400 MHz, respectively.…”

Immunomodulatory, antiglycation and anti-ulcerative properties of <i>Ruellia squarrosa</i> Fenzl Acanthaceae

“…Urease inhibition activity was determined by the indophenol method by using spectrophotometer and taking absorbance at 625 nm. Thiourea was used as the standard inhibitor of urease [13].…”

A Rapid, Efficient and Green Method for Synthesis of 3,3'-Arylmethylene-bis-4-hydroxycoumarins without Use of any Solvent, Catalyst or Solid Surface

“…3,3'-Arylmethylene-bis-4-hydroxycoumarins (3), commonly known as biscoumarins, are the bridge substituted dimers of 4-hydroxycoumarin. They have enormous potential as anticoagulants 1,8,9 and antioxidants 6 and some of them have also been found to be urease inhibitors 10 . The compound 3,3 ′ -methylene-bis-4-hydroxycoumarin, commonly known as dicoumarol, occurs naturally in moldy clover 11 .…”

“…It is the hemorrhagic agent responsible for the sweet clover disease of cattle and has also been employed for the prevention and treatment of thrombosis 12 . 3,3'-Arylmethylene-bis-4-hydroxycoumarins (3) are usually synthesized by condensing 4-hydroxycoumarin (1) with various aldehydes (aromatic, heterocyclic and α,β-unsaturated) (2) using different catalysts and media [8][9][10][13][14][15][16][17][18][19] . Some of these methods require long reaction time, use of expensive catalysts and organic solvents and tedious work up 8,10 .…”

“…3,3'-Arylmethylene-bis-4-hydroxycoumarins (3) are usually synthesized by condensing 4-hydroxycoumarin (1) with various aldehydes (aromatic, heterocyclic and α,β-unsaturated) (2) using different catalysts and media [8][9][10][13][14][15][16][17][18][19] . Some of these methods require long reaction time, use of expensive catalysts and organic solvents and tedious work up 8,10 . The current literature shows that there has been a growing trend towards green synthesis of these compounds [13][14][15][16][17][18][19] .…”