Immunomodulatory, antiglycation and anti-ulcerative properties of &lt;i&gt;Ruellia squarrosa&lt;/i&gt; Fenzl Acanthaceae

Destruction of the tumor (cancerous) cells may be caused by live viruses, which have replicative ability and replicate selectively in tumor cells, known as oncolytic virotherapy. In comparison of conservative cancer therapy, tumor-selective replicating viruses have more advantages. These viruses have introduced new methodologies for the human cancer treatment. Numerous strategies are used in development of virotherapeutics. Virotherapy is not unusual concept, but modern advances in technology of genetic modification of oncolytic viruses have improved the ability of targeting tumor cells more specifically, it triggered the development of novel ammunition to fight cancer. An effective virotherapeutic approach with oncolytic viruses exhibits the feasibility and safety under clinical approach. New strategies are being explored to overcome basic obstacles and challenges in virotherapy. Administration of oncolytic viruses, logically, will successfully augment new treatments against many kinds of tumors. Some encouraging antitumor responses shown by combination therapy are provoking strong immunity against established cancer. Chief developments in oncolytic virotherapy have seen in past several years. Significant understandings have been provided by findings on the interface among immune comebacks and viruses, whereas potential results have shown in clinical trials.

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AIDS Dementia Complex: Neurotoxicity in AIDS Patients

Qadir

Ahmed

Noreen³

2023

Crit Rev Eukaryot Gene Expr

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AIDS dementia complex (ADC) is a nervous system disorder that harms the neurons in different parts of the brain. Various features are involved in altering the normal activities of neurons. Neurotoxicity is induced due to HIV viral proteins such as gp120, SDF, Tat, etc. These proteins target macrophages, glial cells, astrocytes, and release neurotoxins. These neurotoxins proved harmful for the neurons, caused apoptotic cell death by raising calcium, glutamate level and by producing various free radicals such as nitric oxide (NO<sup>·</sup>). Lipid peroxidation and lipids rafts also play a vital role in producing toxicity and apoptotic cell death. Membrane associated oxidative stress, cognitive impairment, and high level of HNE (4-hydroxynonenal); all are involved in ADC pathogenesis.

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Immunomodulatory, antiglycation and anti-ulcerative properties of <i>Ruellia squarrosa</i> Fenzl Acanthaceae

Cited by 7 publications

References 13 publications

Folk medicine, biological activity, and chemical profiles of Brazilian Acanthaceae (Lamiales) - A review

Folk medicine, biological activity, and chemical profiles of Brazilian Acanthaceae (Lamiales) - A review

Oncolytic Virotherapy: An Advanced Microbial Approach for the Management of Cancer

AIDS Dementia Complex: Neurotoxicity in AIDS Patients

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