Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review

Abstract

Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations can lead to new molecular modifications that result in compounds with more desirable pharmacological properties

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

“…Spectral data and elemental analysis conrmed the structures of the synthesized isatin-based azomethine derivatives 2a, 2b, and 3a-d. Bis-Schiff bases are famous for their antitumor, antioxidant, antiglycation, antibacterial, and antiviral activities. [44][45][46] Also, act as inhibitors of enzymes such as a-glucosidase, 47 butrylcholinesterase, and acetylcholinesterase. 48 As shown in Scheme 3, the reaction was readily extended to synthesize a new bis-Schiff base by reaction of 3-hydrazonoindolin-2-one (1) with various bis-aldehyde.…”

Synthesis, Characterization, and Anticancer Potency of Branched Poly (p‐Hydroxy Styrene) Schiff‐Bases

“…[11] The nitrogen atom in azomethine may assist in the formation of a hydrogen bond with the active centers of cell components, altering cell processes. [12][13][14] Additionally, the Schiff base's geometric cavity can govern how the host and visitor interact and its lipophilicity also stimulates synthetic flexibility and selectivity for particles. [15][16][17] To produce large molecular weight conjugated Schiff base polymers, a significant amount of work has been done in recent years.…”