Synthesis, Characterization, and Anticancer Potency of Branched Poly (p‐Hydroxy Styrene) Schiff‐Bases

Abstract

A significant issue in cancer biology is finding anticancer therapies that effectively kill cancer cells. Through the use of several aldehydes, Schiff bases based on branched poly (p‐hydroxy styrene) are created. The branched polymer is first chloroacetylated, then aminated with 1,4‐phenylenediamine, and finally, aldehydes are reacted with the aminated polymer to produce the Schiff base compounds. Through the utilization of FTIR, TGA, XRD, NMR, and elemental analysis, all synthesized Schiff‐bases are identified and characterized. Further, the antineoplastic potential of all Schiff bases is evaluated against different cancer cell lines. The results gained from this study indicate that the Schiff base polymers have cytotoxic power against cancer cells depending on cancer cell type and this antiproliferation potency is dose‐concentration dependent. Importantly, the prepared S1 Schiff‐base polymer shows potent cytotoxicity and is able to trigger the apoptosis and reactive oxygen species (ROS) in MCF‐7 cells. Further, it downregulates VEGFR protein expression. The Schiff base polymers would have extensive applications in the biological disciplines.

Antimicrobial, anti‐inflammatory, and antioxidant evaluations of ammonium and phosphonium salts based on poly(vinylbenzyl chloride‐co‐acrylonitrile)

“…Parcheta and Sobiesiak 12 summarized the recent developments in the domain of polymer surface modification with the purpose of introducing antibacterial properties. Salts of ammonium and phosphonium are among the various antimicrobial polymers 13–16 that have been thoroughly studied and utilized in numerous antimicrobial‐related fields 17–19 …”