Bis(pyridazine-5-olate-4-carboxylate)manganese hydrate: Synthesis, characterization, and in vitro antitumor activities

Sparfloxacin – Cu(ii) – aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation

“…The Annexin V/PI double staining assay was used to further determine the ability of the complexes to induce apoptosis in Eca-109 cells. 51 As can be seen from Fig. 10, the apoptosis rate of the Eca-109 cells in the drug-treated group increased to 25.2% (complex 1 ) and 17.1% (complex 2 ), while that of the control group was 3.8%.…”

“…Both complexes could damage cellular DNA, and complex 1 caused a greater degree of DNA damage compared with complex 2 . 50,51…”

“…Both complexes could damage cellular DNA, and complex 1 caused a greater degree of DNA damage compared with complex 2. 50,51 The mechanism of cell death caused by a drug can be revealed by detecting changes in nuclear morphology by Hoechst 33342 staining. 50 As shown in Fig.…”