Bis(maltolato)vanadium(III)-Polypyridyl Complexes: Synthesis, Characterization, DNA Cleavage, and Insulin Mimetic Activity

Islam, Md. Nazrul; Kumbhar, Avinash S.; Zeller, Mat­thias; Butcher, Raymond J.; Dusane, Menakshi Bhat; Joshi, Bimba N.

doi:10.1021/ic9025359

Cited by 47 publications

(15 citation statements)

References 65 publications

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“…As a part of research program on the interaction of metal polypyridyl complexes with DNA, a series of mixed ligand V(III) complexes was prepared [219], that contained the monoanion of 3-hydroxy-2-methyl-4H-pyran-4-one (maltH) and a N-N hetherocyclic ligand, i.e., 2,2 -bipyridine (bipy), 1,10-phenanthroline (phen), dipyrido [3,2- The hexaanion from 2,5-bis(dicarboxymethyl)aminomethyl-1,4-benzenediol (bicahH 6 ) coordinated two V(III) ions [220], giving a species that at pH 3.2 underwent reversible oxidation to V(IV) ( Table 9, entry 13), whereas reductions resulted ligand-centered.…”

Section: Dinuclear Compoundsmentioning

confidence: 99%

A journey into the electrochemistry of vanadium compounds

Galloni

Conte

2015

Coordination Chemistry Reviews

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Section: Dinuclear Compoundsmentioning

confidence: 99%

A journey into the electrochemistry of vanadium compounds

Galloni

Conte

2015

Coordination Chemistry Reviews

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“…Vanadium-containing complexes with glutamic acid, bipyridine, or hydroxypyridinonate ligands for example [111][112][113][114] exhibit insulin-like properties. Some complexes are also stable in gastric juice, allowing oral administration.…”

Section: Vanadium-and Tungsten-based Pharmaceuticalsmentioning

confidence: 99%

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

Meermann

Sperling

2012

Anal Bioanal Chem

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Method development and applications of hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals are summarized within this review. Advantages and limitations of the separation modes-high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography (GC)-as well as the detection modes-inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization-mass spectrometry (ESI-MS)-are discussed. ICP-MS detection is found to be advantageous for the quantification of drugs containing metals and other heteroatoms. The species-independent sensitivity and multielement capabilities of ICP-MS allow it to be used for quantification even when species-specific standards are not available, as well as to determine the stoichiometry in metallodrug-biomolecule interactions. Molecular information that is totally destroyed when ICP is applied as ionization source and is therefore not obtainable via ICP-MS detection can be accessed by the complementary technique of ESI-MS. Speciation analysis combining both elemental and molecular information is therefore a powerful tool for the analysis of metal-based pharmaceuticals and their metabolites in body fluids and other relevant matrices.

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“…[8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization.…”

Section: Introductionmentioning

confidence: 99%

“…7 Bis(maltolate) metal(IV) complexes are extensively used in medical studies to assess their therapeutic value as active agents against diabetes, as agents for controlling metal levels in the body and as contrast agents in imaging applications. [8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization.…”

Section: Introductionmentioning

confidence: 99%

A New Post-Metallocene-Ti Catalyst with Maltolate Bidentade Ligand: an Investigation in Heterogeneous Polymerization Reactions in Different Mesoporous Supports

Gheno¹,

Basso²,

Livotto³

et al. 2016

Journal of the Brazilian Chemical Society

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A new titanium catalyst easily synthesized from ethylmaltol bidentate chelator ligand was studied in homogeneous and heterogeneous ethylene polymerization. The dichlorobis(3-hydroxy-2-ethyl-4-pyrone)titanium(IV) complex was characterized by 1 H and 13 C NMR (nuclear magnetic resonance), UV-Vis and elemental analysis. Theoretical study by density functional theory (DFT) showed that the complex chlorines exhibit cis configuration, which is important for the activity in olefin polymerization. The complex was supported by two methods, direct impregnation or methylaluminoxane (MAO) pre-treatment, in five mesoporous supports: MCM-41 (micro and nano), SBA-15 and also the corresponding modified Al species. All the catalytic systems were active in ethylene polymerization and the catalytic activity was strongly influenced by the method of immobilization of the catalyst and the type of support. Keywords: catalysis, synthesis, mesoporous support, immobilization, polyethylene IntroductionPolyethylene (PE) has a broad application in different segments of the everyday life, from food packaging to resistant pieces for engineering. Due to the polymer industrial demands, continuous development of new technologies and synthetic methods for obtaining this material are necessary. Existing processes, involving polyethylene synthesis in industrial and/or research scale, use Ziegler-Natta, metallocene, and more recently, postmetallocene catalysts. Our research group has studied the synthesis of different post-metallocene catalysts and tested these complexes in ethylene polymerization. Organometallic complexes of Ti and Zr were obtained from bidentate chelator ligands as naphthoquinone, methylpyrone, ethylpyrone and 3-hydroxyflavone. [1][2][3][4][5] All the synthesized complexes were active in homogeneous ethylene polymerization at different reaction conditions. 3-Hydroxy-2-methyl-4-pyrone (methylpyrone or maltol) is a non-toxic compound of natural occurrence in many plants, 6 while 3-hydroxy-2-ethyl-4-pyrone (ethylmaltol) is a synthetic commercial product. These organic compounds are commonly used in food industries as flavor ingredients. Both hydroxypyrones are characterized by their synthetic versatility and they easily coordinate with transition metals of group IV to give L 2 MCl 2 complexes.7 Bis(maltolate) metal(IV) complexes are extensively used in medical studies to assess their therapeutic value as active agents against diabetes, as agents for controlling metal levels in the body and as contrast agents in imaging applications. [8][9][10][11][12] Maltolate complexes appear attractive to catalyze olefin polymerization reaction as well. In 2001, Sobota et al. 13 synthesized and characterized titanium complexes of methylmaltol and verified their catalytic activity in ethylene and propylene polymerization. Subsequently, our research group has synthesized several Ti and Zr complexes Gheno et al. 2083 Vol. 27, No. 11, 2016 analogous based in maltolate ligands. The synthesized complexes were shown to be active in the ethylene...

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Bis(maltolato)vanadium(III)-Polypyridyl Complexes: Synthesis, Characterization, DNA Cleavage, and Insulin Mimetic Activity

Cited by 47 publications

References 65 publications

A journey into the electrochemistry of vanadium compounds

A journey into the electrochemistry of vanadium compounds

Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications

A New Post-Metallocene-Ti Catalyst with Maltolate Bidentade Ligand: an Investigation in Heterogeneous Polymerization Reactions in Different Mesoporous Supports

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