Bis‐aroylhydrazone based on 2,2′‐bis substituted diphenylamine for synthesis of new binuclear organotin (IV) complexes: Spectroscopic characterization, crystal structures, in vitro DNA‐binding, plasmid DNA cleavage, PCR and cytotoxicity against MCF7 cell line

Abstract

have been synthesized from reaction of R 2 SnCl 2 (R = Me, Ph and Bu) with a 2,2′-bis-substituted diphenylamine arοylidene hydrazone, H 4 L. The synthesized compounds were investigated by elemental analysis and infrared, 1 H-NMR and 119 Sn-NMR spectroscopy. The structures of H 4 L, Me 4 Sn 2 L and Bu 4 Sn 2 L were also confirmed by X-ray crystallography. H 4 L molecules adopt (E)-configuration and keto-tautomeric form in the solid state. In all complexes, the bis-hydrazone acts as a tetra-anionic ligand with two contiguous ONO tridentate domains that coordinate the two R 2 Sn moieties in the enolate form.The coordination environments of both tin centers are five-coordinate. DNAbinding studies were performed by UV-Vis spectroscopy, and the results indicate that the synthesized compounds significantly interact with calf thymus-DNA in the intercalative mode. The results of polymerase chain reaction assay show that all the compounds affect on amplification of DNA, and complexes are more effective than ligands. The in vitro cytotoxicity against the human breast cancer line (MCF7) was determined using the MTT assay, and H 4 L and the dibutytin complex showed higher activity.

Transition metal complexes derived fromN′‐(4‐fluorobenzylidene)‐2‐(quinolin‐2‐yloxy) acetohydrazide: Synthesis, structural characterization, and biocidal evaluation

“…The derivatives of quinoline and hydrazone constitute significant categories of compounds that have found multiple applications in therapeutic chemistry because of their wide range of pharmacokinetic properties, [ 1–3 ] especially their prominence in drug discovery programs. [ 4,5 ] The derivatives of quinoline and hydrazone and their complexes have been reported to demonstrate a widespread spectrum of biological properties, [ 6–8 ] such as antimicrobial, [ 9–11 ] antibacterial, [ 12–14 ] antifungal, [ 15,16 ] antiviral, [ 17 ] antiplatelet [ 18 ] antimalarial, [ 19 ] antitubercular, antimycobacterial, [ 20,21 ] anticancer, [ 21–24 ] antianalgesic, anticonvulsant, [ 25 ] and antileishmanial, [ 26,27 ] The hydrazones and their metal complexes also have anti‐uropathogenic, [ 28 ] anti‐arthritic, [ 29 ] antiproliferative, [ 30 ] and antioxidant [ 31–33 ] properties and act as inhibitors for COX‐2, [ 22 ] potent antiangiogenic agents in atherosclerosis, [ 31 ] and potent immunomodulatory agents. [ 34 ] They play a role in the treatment of Alzheimer's disease [ 35,36 ] and inhibit the corrosion of mild steel in acidic media.…”

A new heterotrimetallic sandwich‐like CuII–LaIII–CuII (3d–4f–3d) cluster as a model anticancer drug in interaction with FS‐DNA and BSA and as a new artificial catalyst for catecholase activity

“…The binding constant (K b ) of the complex is calculated by using Equation . [ 60,61 ] where [DNA] is DNA concentration, ε a is the apparent extinction coefficient that calculated from A obs /[complex], ε f is the extinction coefficient of the free complex, and ε b is the extinction coefficient of the bound complex with DNA. A straight line was produced by plotting Equation , with the slope 1/(ε b − ε f ) and the intercept 1/K b (ε b − ε f ), and the binding constant (K b ) was calculated by dividing the slope to the intercept.…”

Synthesis, characterization, PXRD studies, and theoretical calculation of the effect of gamma irradiation and antimicrobial studies on novel Pd(II), Cu(II), and Cu(I) complexes

“…Hydrazone derivatives are a large class of chemicals used in various medicinal applications ( Abdalla et al, 2021 ) because of their broad range of pharmacokinetic features ( Popiołek et al, 2018 ; Aneja et al, 2019 ; El-saied et al, 2020 ; Katariya et al, 2020 ), particularly in drug detection programmers. The hydrazone and carbaldehyde derivatives, as well as their complexes, have been reported to reveal a wide range of biological features ( Sepay and Dey, 2014 ; Parveen et al, 2018 ; Naveen et al, 2020 ; Zülfikaroğlu et al, 2020 ), such as anticancer ( Mandewale et al, 2017 ; Manohar et al, 2018 ; Yousefi et al, 2019 ; Babahan et al, 2020 ), antibacterial ( Ekennia et al, 2018 ; Özbek et al, 2019 ; Khan et al, 2020 ), antimicrobial ( Cao et al, 2018 ; Philip et al, 2018 ; Santiago et al, 2020 ), antifungal ( Rocha et al, 2019 ; Elsayed et al, 2020 ), antimalarial ( Maurya et al, 2017 ), antiviral ( Sreepriya et al, 2020 ), antimycobacterial ( Mandewale et al, 2017 ; Mandewale et al, 2018 ), antileishmanial ( Coimbra et al, 2019 ), antiplatelet ( Margariti et al, 2020 ), anti-analgesic antitubercular, anticonvulsant ( Dehestani et al, 2018 ), anti-uropathogenic ( Alodeani et al, 2015 ), antiproliferative ( Bergamini et al, 2019 ), antiarthritic ( Shabbir et al, 2014 ), and antioxidant properties ( Vanucci-Bacqué et al, 2016 ; Anastassova et al, 2018 ; Al-Hazmi et al, 2020 ); potent immunomodulatory agents ( Meira et al, 2018 ); and potent antiangiogenic agents in atherosclerosis ( Vanucci-Bacqué et al, 2016 ). They are also essential in Alzheimer’s disease treatment ( Haghighijoo et al, 2017 ; Parlar et al, 2019 ).…”