Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children

Martínez‐Aguayo, Alejandro; Aglony, Marlene; Bancalari, Rodrigo; Avalos, Carolina; Bolte, Lillian; García, Hernán; Loureiro, Carlos Alfredo; Carvajal, Cristián A.; Campino, Carmen; Inostroza, Andrea; Fardella, Carlos E.

doi:10.1111/j.1365-2265.2011.04308.x

Cited by 44 publications

(37 citation statements)

References 39 publications

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“…To our knowledge, no other human studies have reported on the association between pBMI and activation of the autonomic nervous system at rest; this topic warrants further investigation. Similar to others, we found that BW was inversely related to blood pressure [27][28][29][30] ; no evidence was found for a U-shaped curve. Although Filler et al 12 found a positive relation between high BW and high blood pressure, we could not confirm these findings; however, they did not use age, sex, and height standardization of blood pressure, and included hospitalized patients.…”

Section: Discussionsupporting

confidence: 73%

Maternal Prepregnancy Body Mass Index and Their Children’s Blood Pressure and Resting Cardiac Autonomic Balance at Age 5 to 6 Years

Gademan

Eijsden²,

Roseboom³

et al. 2013

Hypertension

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Adverse intrauterine conditions can program hypertension. Because one of the underlying mechanisms is thought to be cardiac autonomic balance, we investigated the association between prepregnancy body mass index (BMI) and blood pressure and indicators of the autonomic balance in the child at age 5 to 6 years. Also investigated was whether these associations were mediated by standardized birth weight and child BMI. Pregnant women (n=3074) participating in the Amsterdam Born Children and their Development study completed a questionnaire at gestational week 14. At age 5 to 6 years, offspring’s sympathetic drive (pre-ejection period), parasympathetic drive (respiratory sinus arrhythmia), and heart rate were measured by electrocardiography and impedance cardiography at rest. Blood pressure was assessed simultaneously. After adjusting for possible maternal/offspring confounders, prepregnancy BMI was positively linearly associated with diastolic blood pressure (β=0.11 mm Hg; 95% confidence interval, 0.05–0.17), systolic blood pressure (β=0.14 mm Hg; 95% confidence interval, 0.07–0.21), but not with heart rate, sympathetic or parasympathetic drive. After adding birth weight and child BMI to the model, the independent effect size of prepregnancy body mass index on systolic blood pressure (β=0.07 mm Hg; 95% confidence interval, 0.00–0.14) and diastolic blood pressure (β=0.07 mm Hg; 95% confidence interval, 0.01–0.13) decreased by ≈50%. Birth weight did not mediate these relationships, but was independently and negatively associated with blood pressure. Child BMI was positively associated with blood pressure and partly mediated the association between prepregnancy BMI and blood pressure. In conclusion, higher prepregnancy BMI is associated with higher blood pressure in the child (aged 5–6 years) but does not seem to be attributable to early alterations in resting cardiac autonomic balance. Child BMI, but not birth weight, mediated the association between prepregnancy BMI and blood pressure.

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Section: Discussionsupporting

confidence: 73%

Maternal Prepregnancy Body Mass Index and Their Children’s Blood Pressure and Resting Cardiac Autonomic Balance at Age 5 to 6 Years

Gademan

Eijsden²,

Roseboom³

et al. 2013

Hypertension

View full text Add to dashboard Cite

show abstract

“…This finding confirms the reliability of salivary cortisol measurements shown before in premature infants (15) and older children (16). We did not find the inverse relation between birth weight and cortisol levels as shown in other studies in children (7,17).…”

Section: Articles De Jong Et Alsupporting

confidence: 40%

“…In adults birth weight is inversely associated with cortisol levels and cortisol levels are positively correlated to blood pressure (5,6). This was also shown in children between the ages of 4.9 and 15.5 y and born at a gestational age >32 wk (7). In preterm born young adult men, cortisol is also associated with high systolic blood pressure (8).…”

mentioning

confidence: 57%

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

2015

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“…As observed in a large Swedish study including more than 1000 children aged 5-14 years [36], morning cortisol was not related to systolic or diastolic blood pressure in our study. Furthermore, our data could not confirm an inverse association between low birth weight and cortisol levels [37]. …”

Section: Discussionmentioning

confidence: 66%

Gender-Specific Alterations in Salivary Cortisol Levels in Pubertal Intracytoplasmic Sperm Injection Offspring

Belva¹,

Painter²,

Schiettecatte

et al. 2013

Horm Res Paediatr

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Background: There is accumulating evidence that in vitro conception in humans may be associated with adverse health outcomes later in life. It has been proposed that suboptimal early life conditions may ‘program' key endocrine systems. A disturbance of the hypothalamic-pituitary-adrenal (HPA) axis leading to alterations in cortisol secretion in the offspring may be such a mechanism. To date, no data on cortisol levels in children conceived by intracytoplasmic sperm injection (ICSI) are available in the literature. Methods: In this cross-sectional study, salivary cortisol known as a key regulator of metabolism was measured and results were compared between 201 pubertal ICSI children and 196 spontaneously conceived (SC) counterparts. Results: ICSI females had lower mean salivary cortisol levels (9.0 µg/l; 95% CI 8.1-9.9) than SC females (10.6 µg/l; 95% CI 9.7-11.5; p = 0.01). This difference remained after adjusting for current characteristics, early life factors and maternal characteristics. In ICSI males, no difference in cortisol levels was found in comparison with the SC group. Conclusion: In our study, 14-year-old female but not male ICSI teenagers were found to have lower salivary cortisol concentrations in comparison with SC peers. However, before definite conclusions can be drawn, our results should be completed by longitudinal sampling.

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Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children

Abstract: The results of this study demonstrate an inverse association between birth weight and blood pressure and serum aldosterone and cortisol levels. This association is independent of BMI and Tanner, suggesting foetal programming of the hypothalamic-pituitary-adrenal axis.

Cited by 44 publications

References 39 publications

Maternal Prepregnancy Body Mass Index and Their Children’s Blood Pressure and Resting Cardiac Autonomic Balance at Age 5 to 6 Years

Maternal Prepregnancy Body Mass Index and Their Children’s Blood Pressure and Resting Cardiac Autonomic Balance at Age 5 to 6 Years

Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

Gender-Specific Alterations in Salivary Cortisol Levels in Pubertal Intracytoplasmic Sperm Injection Offspring

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