Birth weight and ovulatory dysfunction

Abstract

Objective To explore the association between birthweight and ovulatory dysfunction in adulthood. Design Case–control study. Setting Northeast of Scotland University Hospital, hosting the regional fertility centre and maternity unit. Population A total of 18 846 mother–daughter record pairs from the Aberdeen Fertility Centre Data Set and the Aberdeen Maternity and Neonatal Databank (AMND). Cases were the daughters with ovulatory dysfunction attending the Aberdeen Fertility Centre between 1992 and 2007, Control group 1 included the daughters attending the fertility centre with confirmed ovulation, and Control group 2 included all women naturally fertile who gave birth in Aberdeen during the same period. Methods The electronic maternity records of the mothers of women in the three groups were retrieved from AMND and compared. Main outcome measures Daughters' birthweight and standardised birthweight, characteristics of mothers and daughters at delivery and current daughters' characteristics. Results Cases, Control group 1 and Control group 2 included 466, 548 and 17 832 daughters, respectively. The mean birthweight (standard deviation) in grams was comparable between Cases 3203 (522), Control group 1, 3235 (482) P = 0.30, and Control group 2, 3226 (495) P = 0.31. The proportions of daughters born small for gestational age, large for gestational age, or preterm were comparable between the Cases group and each Control group, as was the mode of delivery and Apgar scores at 1 and 5 minutes. The age at delivery, body mass index, social class or pregnancy complications were comparable in the mothers of the Cases and each Control group. Conclusions Ovulatory dysfunction does not appear to be related to birthweight or perinatal events.

Vigilância Do Crescimento E Desenvolvimento: Análise Dos Registros Na Caderneta De Saúde Da Criança

“…Isso pode ser justificado por se tratar de uma das informações mais requeridas do recém-nascido, tanto pela sua família quanto pelos profissionais; para esses, o peso ao nascer é um dado fundamental, tendo em vista que algumas doenças que acometem os adultos estão relacionadas às alterações no crescimento e desenvolvimentos intrauterinos, a exemplo das doenças cardiovasculares, metabólicas e endócrinas na vida adulta (14) .…”

Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause

“…Although SGA women in Brazil (Melo et al 2010) and those with LBW in Italy (Pandolfi et al 2008) and Turkey (Hizli et al 2012) present a higher risk for developing PCOS, these findings were not confirmed in individuals from the USA (Legro et al 2010), UK (Cresswell et al 1997, Michelmore et al 2001, Shayeb et al 2014, The Netherlands (Sadrzadeh et al 2003), Finland (Laitinen et al 2003), Spain (Ibáñ ez et al 2008) or Denmark (Mumm et al 2013). One study conducted in Australia analysed birth weight as a continuous variable and found that each 100 g increase in birth weight increased the risk of hyperandrogenism.…”

“…The authors of that study also found that the subjects' thinness was related to PCOS symptoms and to IR (Davies et al 2012; Table 3). These apparent regional differences may result from the limitations of these studies, which include the use of varying definitions of PCOS (Cresswell et al 1997, Laitinen et al 2003, Sadrzadeh et al 2003, Ibáñ ez et al 2008, Hizli et al 2012, Mumm et al 2013, the inclusion of women using hormonal contraceptives (Ibáñ ez et al 2007, Davies et al 2012, Mumm et al 2013, the small numbers of participants (Ibáñez et al 2001, Pandolfi et al 2008, the use of self-reported birth data (Laitinen et al 2003, Sadrzadeh et al 2003, Legro et al 2010, Hizli et al 2012, the inclusion of women with immature HPG axes (Ibáñ ez et al 2001) and the absence of compensatory growth assessments (Cresswell et al 1997, Michelmore et al 2001, Laitinen et al 2003, Sadrzadeh et al 2003, Ibáñez et al 2008, Pandolfi et al 2008, Legro et al 2010, Melo et al 2010, Hizli et al 2012, Mumm et al 2013, Shayeb et al 2014. The use of birth weight classifications as an exposure factor across studies was perhaps the most important limitation, because not all of the studies adjusted the subjects' birth weight for GA. For that reason, some of the studies included preterm newborn infants.…”

“…The use of birth weight classifications as an exposure factor across studies was perhaps the most important limitation, because not all of the studies adjusted the subjects' birth weight for GA. For that reason, some of the studies included preterm newborn infants. This feature might indicate the presence of selection bias (Cresswell et al 1997, Michelmore et al 2001, Sadrzadeh et al 2003, Ibáñ ez et al 2008, Legro et al 2010, Hizli et al 2012, Mumm et al 2013, Shayeb et al 2014, especially considering that the functional maturation of organs and tissues of a preterm newborn is completed during postnatal life (Ben 2008).…”

“…Because the cardio-metabolic profile of PCOS phenotypes characterised by hyperandrogenism and chronic anovulation is poorer, the inclusion of nonhyperandrogenic phenotypes might favour the occurrence of bias in the assessment of the aetiopathogenesis of PCOS and its relationship to cardiovascular comorbidities during late stages of life (Melo et al 2011, Daan et al 2014. Moreover, most of the existing studies are multicentre cross-sectional or case-control studies in which women at different stages of life and who have a varied prevalence of comorbidities associated with PCOS were analysed (Michelmore et al 2001, Ibáñ ez et al 2008, Legro et al 2010, Chen et al 2011, Hizli et al 2012, Hwang et al 2012, Shi et al 2012, Louwers et al 2013, Shayeb et al 2014.…”