“…FGFR activation by FGFs (fibroblast growth factors) can induce several different cell processes, such as differentiation, proliferation, migration, and apoptosis by Roberto D Fanganiello, 1 Andréa L Sertié, 1 Eduardo M Reis, 2 Erika Yeh, 1 Nélio AJ Oliveira, 1 Daniela F Bueno, 1 Irina Kerkis, 3 Nivaldo Alonso, 4 Sérgio Cavalheiro, 5 Hamilton Matsushita, 5 Renato Freitas, 6 Sergio Verjovski-Almeida, 2 and Maria Rita Passos-Bueno Apert syndrome (AS), a severe form of craniosynostosis, is caused by dominant gain-of-function mutations in FGFR2. Because the periosteum contribution to AS cranial pathophysiology is unknown, we tested the osteogenic potential of AS periosteal cells (p.Ser252Trp mutation) and observed that these cells are more committed toward the osteoblast lineage.…”