Birth prevalence of congenital heart disease: A cross-sectional observational study from North India

Saxena, Anitá; Mehta, Anurag; Sharma, Mamta; Salhan, Sudha; Kalaivani, Mani; Ramakrishnan, Sivasubramanian; Juneja, Rajnish

doi:10.4103/0974-2069.189122

Cited by 61 publications

(63 citation statements)

References 20 publications

(21 reference statements)

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“…The present study on Sickneonates we observed a prevalence rate of 26 % which seems higher than other studies but may be explained by inclusion of more sick neonates We observed VSD in 28.2 percent of cases followed closely by ASD in about 21 % of cases VSD PDA 19.8 and PDA alone in 9.9 % of cases in sharp contrast to earlier study by Saxena et all who observed. [1][2][3]17] VSDs (restrictive and non restrictive) were the most common significant CHDs (43.9% and 20.7%, respectively) with a prevalence rate of 5.22 per 1000 live births. ASDs and PDAs consisted of 7.3% and 4.3% of the significant CHDs, with a prevalence rate of 0.59/1000 and 0.34/1000, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Congenital Heart Disease in Sick Neonates: An Echocardiographic Evaluation

Sharma¹,

Acharya²,

Sahoo³

et al. 2018

AIMDR

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Background: Congenital heart disease (CHD) is one of the major causes of mortality and morbidity in the paediatric population particularly in neonates and infants of both the developing and developed countries. Importance of congenital defects is more prominent in infants and delay in recognition may adversely effect survival. Objective: To find the prevalence and pattern of CHD in sick neonates in a tertiary care hospital VSSIMSAR Odisha India catering to economically backward area of our country. Methods: A prospective analysis of case of 8.856 patients (0-1 month) was conducted to ascertain the prevalence and spectrum of CHDs. Results: A total of 232 patients out of 8.856, were found having CHDs measuring a prevalence of 26.2/1000 among sick neonates. About 202 (91.3%) were the acyanotics and 20 (8.6%) were cyanotic heart patients. 4 (1.7%)were complex congenital heart disease Among the acyanotic heart diseases the most frequent lesion seen in 126 (62.7%) followed by ASD alone or in combination was detected in 76 cases (37.6 %) followed by PDA alone or in combination in around 74 cases(36.6%). Combined defects PDA and VSD in 40 cases (20.2 %). Valvular PS was observed in 3% of cases among the cyanotic heart diseases Tetralogy of Fallot was the most frequent cyanotic heart disease seen in 9 cases. Conclusion: Prevalence of congenital heart disease is very high among the sick neonates though figure of 26.2/1000 among the sick neonates could be an over estimation of the actual disease burden in our community because of high prevalence of sick children. The study heightened awareness among the treating physicians about the high prevalence of cardiac diseases in sick neonates and early recognition is essential to reduce the mortality and morbidity associated with these ailments.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Congenital Heart Disease in Sick Neonates: An Echocardiographic Evaluation

Sharma¹,

Acharya²,

Sahoo³

et al. 2018

AIMDR

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“…Khalil et al (15) 1994 Indian Pediatrics Hospital Live births 10964 3.9/1000 Kapoor R et al (9) 2007 Indian Pediatrics Hospital (Kanpur) 0-15 yrs. 10641 26/1000 M Mishra (16) 2009 IHJ Community (UP) 5-15 yrs. 118212 1.3/1000 Bhat NK (17) 2013 Indian journal of Pediatrics Hospital (Uttarakhand) 0-18 yrs.…”

Section: Chd Detected Bymentioning

confidence: 99%

Echocardiography Based Study of the Prevalence and Pattern of Congenital Heart Disease (Chd) in 5-15 Years Old School Going Children of Manipur, a North-East Hilly Indian State

Thangjam¹,

Rothangpui²,

Irom³

et al. 2017

jebmh

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BACKGROUND CHD is the leading cause of morbidity and mortality in the developed world, while reports from India looking into the burden of the disease have been variable depending on the age group of subjects studied and the methodology involved. We were interested to find the prevalence and pattern of the disease in this north eastern Indian state of Manipur, which has a unique geographical and racial composition. MATERIALS AND METHODS This is a community based, prospective, cross sectional study where each and every child aged 5-15 years from randomly selected schools of Manipur were examined by 2D colour Doppler Echocardiography and physically as well, where the examiners were blinded, and the findings were noted independent of each other. The anthropometric parameters, clinical details and echocardiography findings were all recorded. RESULTS Of the 3600 children examined, 47 cases of CHD were detected, giving echocardiographic prevalence of 13 per 1000 where BAV (44%) was found as the commonest lesion followed by VSD (17%) and ASD (14%). Clinically detectable lesion was found in 21 subjects (VSD-8, ASD-7, PS-3, PDA-1, AVSD-1, BAV-1 with AR). Of the clinically detectable CHD, VSD was the commonest followed by ASD. In the subclinical CHD category, 20 cases of BAV, 4 cases of mild MVP without MR, 1 case of apical LV discompacta, 1 case of IASA were detected. CONCLUSION The echocardiography prevalence of congenital heart disease in school going children of Manipur is 13/1000. This highest ever reported prevalence of CHD in children is most probably related to the use of the highly sensitive investigative tool of Echocardiography in each subject of our study resulting in detection of clinically silent lesions.

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“…Cardiac septal defects (CSDs) constitute 1% of all congenital heart diseases (CHDs) [1]. The prevalence of CHD worldwide (population based) is between 1 and 150/1000 live births, while in India, it is 8.07/1000 live births [2]. However, septal defects have a reported frequency of 4.1/1000 live births.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Gene Copy Number Variations in Patients With Cardiac Septal Defects Using Multiplex Ligation-Dependent Probe Amplification

Borkar

Nayak

et al. 2019

Asian J Pharm Clin Res

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Objective: Cardiac septal defects (CSDs), the most common human congenital heart malformations are complex and heterogeneous. Progress in molecular biology has helped to identify many genes responsible for cardiac morphogenesis. However, etiologic factors in familial as well as isolated syndromes are being identified; the root genetic cause still needs to be resolved and its mechanism is yet to be revealed. The objective of this study is to identify DNA copy number variations (CNVs) and their possible association with septal defects. Methods: Multiplex ligation-dependent probe amplification (MLPA) was used to detect DNA copy number in non-syndromic CSDs using the P311-A1 Kit consisting of probes for the key genes, namely, NKX2-5 (NK2 transcription factor related, locus 5), GATA4 (GATA binding protein 4), TBX5 (T-box transcription factor), bone morphogenetic protein 4, and CRELD1 (cysteine rich with EGF-like domains 1). Results: We studied 124 clinically diagnosed CSD subjects, of which 111 (89.5%) had atrial septal defects and 13 (10.5%) had ventricular septal defects. MLPA assay was carried out in all these patients after a thorough clinical and cytogenetic screening. CNVs were identified in 16 (12.9%) cases, of which heterozygous deletions and heterozygous duplications were detected (8 patients each) with apparent phenotypes. Conclusion: MLPA could be a useful assay for the detection of CNVs and to be adopted as the first line of screening in patients with congenital heart diseases.

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Birth prevalence of congenital heart disease: A cross-sectional observational study from North India

Cited by 61 publications

References 20 publications

Prevalence of Congenital Heart Disease in Sick Neonates: An Echocardiographic Evaluation

Prevalence of Congenital Heart Disease in Sick Neonates: An Echocardiographic Evaluation

Echocardiography Based Study of the Prevalence and Pattern of Congenital Heart Disease (Chd) in 5-15 Years Old School Going Children of Manipur, a North-East Hilly Indian State

Analysis of Gene Copy Number Variations in Patients With Cardiac Septal Defects Using Multiplex Ligation-Dependent Probe Amplification

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