Birth Prevalence of Congenital Heart Disease Worldwide

Linde, Denise van der; Konings, Elisabeth E.M.; Slager, Maarten A.; Witsenburg, Maarten; Helbing, Willem A.; Takkenberg, Johanna J.M.; Roos‐Hesselink, Jolien W.

doi:10.1016/j.jacc.2011.08.025

Cited by 2,666 publications

(1,986 citation statements)

References 21 publications

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“…It has increased steadily since 1930. The birth prevalence since 1995 ranges between 1.9 and 9.3/1000 births [4], [5], [8]. The current lower prevalence in Africa is similar to that in the West in the early 1930s (0.6/1000 births) and is probably related to an under diagnosis.…”

Section: Introductionmentioning

confidence: 92%

“…Congenital heart disease (CHD) and early acquired heart disease (EAHD) are of special importance in adolescents as they may impact their subsequent health as they age [2], [3]. Many studies which investigated the prevalence of CHD in fetal and newborn populations found fewer subjects than in population studies of older children and adolescents [4], [5]. Echocardiographic screening revealed a prevalence rate of approximately 3.5% for cardiac lesion in older children [6], [7].…”

Section: Introductionmentioning

confidence: 99%

“…The current lower prevalence in Africa is similar to that in the West in the early 1930s (0.6/1000 births) and is probably related to an under diagnosis. The best estimate of today's worldwide rate is 9.1/1000 births [5].…”

Section: Introductionmentioning

confidence: 99%

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Cardiac anomalies and associated comorbidities in a large adolescent population

Fink

Machluf

Farkash

et al. 2017

International Journal of Adolescent Medicine and Health

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Abstract:Objective: To determine the prevalence, secular trends and associations of heart disease in a large unscreened, otherwise basically healthy, adolescent population. Subjects and methods: Cross-sectional study of the cardiac status of 113,694 adolescents from the northern district of Israel, who completed the profiling process between the ages of 16 and 19, including all essential measures over a 22-year period. Results of imaging were categorized as either isolated valvar or structural abnormalities, and their clinically significant subgroups defined prospectively. The findings were correlated with the socio-demographic and anthropometric data and non-cardiac health conditions. Results: Of those sent for echocardiography, 1257 (0.93% of the total population) had isolated valvar disease and 216 (0.19%) had structural abnormalities, with 20% of both groups considered significant. Females had lower prevalence of heart disease. There was peak prevalence in the second 5-year period. Tall subjects or a past history of rheumatic fever had more valvar abnormalities. Thin subjects or those with skeletal anomalies had more structural abnormalities. Significant valvar and structural anomalies were more common in subjects with learning disorders, endocrine disorders and diabetes mellitus. Fewer valvar abnormalities were diagnosed in obese subjects. Heart disease was more common in those with non-solid tumors. Conclusion: Appreciable numbers of potentially healthy adolescents were found to have heart disease. There appeared to be an association with body size, skeletal abnormalities and relatively common medical disorders, the cause of which remains to be determined in prospective studies that could change the way common adolescent disease should be followed.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Cardiac anomalies and associated comorbidities in a large adolescent population

Fink

Machluf

Farkash

et al. 2017

International Journal of Adolescent Medicine and Health

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“…The incidence has been reported to be around 1/33 000 live births, accounting for ≈0.05% of congenital heart malformations 2. Although a familial recurrence of heart defects in subjects with ccTGA has been reported,3 the etiology of this malformation is not currently known 1, 4…”

Section: Introductionmentioning

confidence: 99%

Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance

Baruteau

Abrams

et al. 2017

JAHA

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“…Congenital heart disease (CHD) is the most common category of birth defect, with an incidence rate between 0.3% and 0.8% 1, 2. Critical CHD (CCHD)—defined as requiring neonatal intervention—is reported to have an incidence rate of 0.17% 3.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Steurer

Baer

Burke

et al. 2018

JAHA

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BackgroundInfants with critical congenital heart disease (CCHD) are more likely to be small for gestational age (GA). It is unclear how this affects mortality. The authors investigated the effect of birth weight Z score on 1‐year mortality separately in preterm (GA <37 weeks), early‐term (GA 37–38 weeks), and full‐term (GA 39–42 weeks) infants with CCHD.Methods and ResultsLive‐born infants with CCHD and GA 22 to 42 weeks born in California 2007–2012 were included in the analysis. The primary predictor was Z score for birth weight and the primary outcome was 1‐year mortality. Multivariable logistic regression was used. Results are presented as adjusted odds ratios and 95% confidence intervals (CIs). The authors identified 6903 infants with CCHD. For preterm and full‐term infants, only a Z score for birth weight <−2 was associated with increased mortality compared with the reference group (Z score 0–0.5, adjusted odds ratio, 2.15 [95% CI, 1.1–4.21] and adjusted odds ratio, 3.93 [95% CI, 2.32–6.68], respectively). In contrast, in early‐term infants, the adjusted odds ratios for Z scores <−2, −2 to −1, and −1 to −0.5 were 3.42 (95% CI, 1.93–6.04), 1.78 (95% CI, 1.12–2.83), and 2.03 (95% CI, 1.27–3.23), respectively, versus the reference group.Conclusions GA seems to modify the effect of birth weight Z score on mortality in infants with CCHD. In preterm and full‐term infants, only the most severe small‐for‐GA infants (Z score <−2) were at increased risk for mortality, while, in early‐term infants, the risk extended to mild to moderate small‐for‐GA infants (Z score <−0.5). This information helps to identify high‐risk infants and is useful for surgical planning.

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Birth Prevalence of Congenital Heart Disease Worldwide

Cited by 2,666 publications

References 21 publications

Cardiac anomalies and associated comorbidities in a large adolescent population

Cardiac anomalies and associated comorbidities in a large adolescent population

Cardiac Conduction System in Congenitally Corrected Transposition of the Great Arteries and Its Clinical Relevance

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

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