Birth defects in medically assisted reproduction pregnancies in the city of Barcelona

Gutarra-Vilchez, Rosa; Santamariña-Rubio, Elena; Salvador, Joaquín; Borrell, Antoni

doi:10.1002/pd.4286

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…In Israel, the percentage of major malformations in infants conceived by ART in 1986ART in -1994ART in and 1995ART in -2002 was also double that of the general population during the same periods. 36 Similar reports have been observed in Spain, 37 France, 38 Canada 39 and the United States 40,41 (summarized in Table 2). Large meta-analyses have been conducted and show that children born after ART have a 30-40% increased risk of birth defects compared with spontaneous conceptions.…”

Section: Birth Defects In Art Singleton Pregnanciessupporting

confidence: 79%

The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

Chen

Heilbronn

2017

J Dev Orig Health Dis

134

122

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Concerns have been raised about the health and development of children conceived by assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked with adverse obstetric and perinatal outcomes, an increased risk of birth defects, cancers, and growth and development disorders. Emerging evidence suggests that ART treatment may also predispose individuals to an increased risk of chronic ageing related diseases such as obesity, type 2 diabetes and cardiovascular disease. This review will summarize the available evidence on the short-term and long-term health outcomes of ART singletons, as multiple pregnancies after multiple embryos transfer, are associated with low birth weight and preterm delivery, which can separately increase risk of adverse postnatal outcomes, and impact long-term health. We will also examine the potential factors that may contribute to these health risks, and discuss underlying mechanisms, including epigenetic changes that may occur during the preimplantation period and reprogram development in utero, and adult health, later in life. Lastly, this review will consider the future directions with the view to optimize the long-term health of ART children.

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Section: Birth Defects In Art Singleton Pregnanciessupporting

confidence: 79%

The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

Chen

Heilbronn

2017

J Dev Orig Health Dis

134

122

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“…The PRISMA statement was used for reporting the Methods, Results and Discussion sections of the current review. Extracted data from all included articles are shown in Table S1.…”

Section: Methodsmentioning

confidence: 99%

Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta‐analysis

Giorgione

Parazzini

Fesslová

et al. 2018

Ultrasound in Obstet & Gyne

153

103

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Objective There is no consensus in current practice guidelines on whether conception by in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) techniques is an indication for performing a fetal echocardiogram.The aim of the study was to assess whether congenital heart defects (CHD) occur more often in pregnancies conceived after IVF/ICSI as compared with those conceived spontaneously. Methods

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“…Some studies report an almost threefold increased risk of congenital malformations in pregnancies conceived by artificial techniques compared to natural conception [12,13], whereas others fail to identify this association [14]. All categories of birth defects are observed except those of head, face, neck, and eye.…”

Section: Methods Of Conceptionmentioning

confidence: 99%

Fetal Dysmorphology

Puri

2015

Journal of Fetal Medicine

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Examination of the fetus with congenital anomalies is essential to identify the nature of the defects and determine if they constitute a part of a recognized abnormality of development and morphogenesis. A structured approach, including a comprehensive history and details of the anomalies present, assists in making a definitive diagnosis. Dysmorphic diagnosis in the fetus is a challenge as the complete phenotype may not be manifested, coupled with the possibility of subtle dysmorphism that is difficult to recognize. Correlation of the antenatal scan findings with those at autopsy, combined with the experienced eye of a clinical geneticist, is helpful in making a syndrome diagnosis. Specialized databases, reference textbooks, and previously published malformation syndromes are important aids for the geneticist. An accurate diagnosis is important to counsel families of the prognosis, available treatment options, and recurrence risks in future conceptions. New technologies for genetic testing are available to confirm a syndrome diagnosis and consequently, it is vital that appropriate fetal samples are stored in all cases. A team approach with expert input from a fetal medicine specialist, perinatal pathologist, geneticist, radiologist, and the genetics laboratory are important components of fetal dysmorphic syndrome identification.

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Birth defects in medically assisted reproduction pregnancies in the city of Barcelona

Abstract: This study demonstrated a strong association between ART and BD, with an almost threefold increased risk for overall BD after ART, as compared with natural conception. Increased associations were also observed for almost all structural BD categories.

Cited by 11 publications

References 27 publications

The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta‐analysis

Fetal Dysmorphology

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