Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization

Salaneck, Erik; Larsson, Tomas; Larson, Earl T.; Larhammar, Dan

doi:10.1016/j.gene.2007.11.011

Cited by 48 publications

(39 citation statements)

References 77 publications

(82 reference statements)

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“…To date, research on the biology of bony fish spermatozoa has mainly focused on the spermatozoon ultrastructure, sperm motility, and sperm cryopreservation [5, 50]. Tetraploidization in fish during culture is most common in cyprinids, salmonids, and catostomids [51–53]. However, there are rarely existence bisexual fertile allotetraploid fish, especially fertile male allotetraploid are difficult to produce.…”

Section: Discussionmentioning

confidence: 99%

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Zhou

et al. 2017

Biology of Reproduction

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Sperm motility is an important standard to measure the fertility of male. In our previous study, we found that the diploid spermatozoa from allotetraploid hybrid (4nAT) had longer durations of rapid and slow progressive motility than haploid spermatozoa from common carp (COC). In this study, to explore sperm motility-related molecular mechanisms, we compared the testis tissues transcriptomes from 2-year-old male COC and 4nAT. The RNA-seq data revealed that 2985 genes were differentially expressed between COC and 4nAT, including 2216 upregulated and 769 downregulated genes in 4nAT. Some differentially expressed genes, such as tubulin genes, dynein, axonemal, heavy chain(dnah) genes, mitogen-activated protein kinase(mapk) genes, tektin 4, FOX transcription factors, proteasome genes, and ubiquitin carboxyl-terminal hydrolase(uchl) genes, are involved in the regulation of cell division, flagellar and ciliary motility, gene transcription, cytoskeleton, energy metabolism, and the ubiquitin–proteasome system, suggesting that these genes were related to sperm motility of the 4nAT. We confirmed the differential expression of 12 such genes in 4nAT by quantitative PCR. By western blotting, we also confirmed increased expression of Uchl3 in 4nAT testis. In addition, we identified 1915 and 2551 predicted long noncoding RNA (lncRNA) transcripts from testis tissue transcriptomes of COC and 4nAT, respectively. Of these, 1575 lncRNAs were specifically expressed in 4nAT and 939 were specifically expressed in COC. This study provides insights into the transcriptome profile of testis tissues from diploid and tetraploid, which are useful for research on regulatory mechanisms behind sperm motility in male polyploidy.

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Section: Discussionmentioning

confidence: 99%

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Zhou

et al. 2017

Biology of Reproduction

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“…However, receptor losses are extremely seldom in these animals, and we are aware of only one example, where three (out of originally seven) neuropeptide Y receptor subtypes have been lost in some teleost fishes (32). To our knowledge, there are no examples of losses of whole hormonal (receptor plus ligand) systems in vertebrates, such as we have seen for the ACP system in branches of the Hymenoptera and Diptera (Fig.…”

Section: Discovery Of a Novel Hormonal Signaling System In Insectsmentioning

confidence: 94%

Discovery of a Novel Insect Neuropeptide Signaling System Closely Related to the Insect Adipokinetic Hormone and Corazonin Hormonal Systems

Hansen

Stafflinger

Schneider

et al. 2010

Journal of Biological Chemistry

157

217

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Neuropeptides and their G protein-coupled receptors (GPCRs) play a central role in the physiology of insects. One large family of insect neuropeptides are the adipokinetic hormones (AKHs), which mobilize lipids and carbohydrates from the insect fat body. Other peptides are the corazonins that are structurally related to the AKHs but represent a different neuropeptide signaling system. We have previously cloned an orphan GPCR from the malaria mosquito Anopheles gambiae that was structurally intermediate between the A. gambiae AKH and corazonin GPCRs. Using functional expression of the receptor in cells in cell culture, we have now identified the ligand for this orphan receptor as being pQVTFSRDWNAamide, a neuropeptide that is structurally intermediate between AKH and corazonin and that we therefore named ACP (AKH/corazonin-related peptide). ACP does not activate the A. gambiae AKH and corazonin receptors and, vice versa, AKH and corazonin do not activate the ACP receptor, showing that the ACP/ receptor couple is an independent and so far unknown peptidergic signaling system. Because ACP is structurally intermediate between AKH and corazonin and the ACP receptor between the AKH and corazonin receptors, this is a prominent example of receptor/ligand co-evolution, probably originating from receptor and ligand gene duplications followed by mutations and evolutionary selection, thereby yielding three independent hormonal systems. The ACP signaling system occurs in the mosquitoes A. gambiae, Aedes aegypti, and Culex pipiens (Diptera), the silkworm Bombyx mori (Lepidoptera), the red flour beetle Tribolium castaneum (Coleoptera), the parasitic wasp Nasonia vitripennis (Hymenoptera), and the bug Rhodnius prolixus (Hemiptera). However, the ACP system is not present in 12 Drosophila species (Diptera), the honeybee Apis mellifera (Hymenoptera), the pea aphid Acyrthosiphon pisum (Hemiptera), the body louse Pediculus humanus (Phthiraptera), and the crustacean Daphnia pulex, indicating that it has been lost several times during arthropod evolution. In particular, this frequent loss of hormonal systems is unique for arthropods compared with vertebrates.

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“…The physiological functions of NPY are mediated by Y receptors, belonging to the rhodopsin-like Gi coupled Gprotein coupled receptor (GPCR) family and four subtypes, Y1R, Y2R, Y4R and Y5R have been identified in humans. [4][5][6] Y1R is expressed abundantly in both central and peripheral sympathetic nervous systems, and the NPY/Y1R signalling cascade is implicated in various physiological responses, including regulation of feeding behaviour, 7,8 stimulation of ethanol intake, 9,10 vasoconstriction 11,12 and initiation of anxiety and depression. 13,14 In addition, breast carcinomas, including primary tumours and lymph node metastases, have also been found to over-express Y1R.…”

Section: Identification Of a Cyanine-dye Labelled Peptidic Ligand Formentioning

confidence: 99%

Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y₁R and Y₄R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15

et al. 2016

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Traceable truncated Neuropeptide Y (NPY) analogues with Y 1 receptor (Y 1 R) affinity and selectivity are highly desirable tools in studying receptor location, regulation, and biological functions. A range of fluorescently labeled analogues of a reported Y 1 R/Y 4 R preferring ligand BVD-15 have been prepared and evaluated using high content imaging techniques. One peptide, [Lys 2 (sCy5), Arg 4 ]BVD-15, was characterized as an Y 1 R antagonist with a pK D of 7.2 measured by saturation analysis using fluorescent imaging. The peptide showed 8-fold lower affinity for Y 4 R (pK D = 6.2) and was a partial agonist at this receptor. The suitability of [Lys 2 (sCy5), Arg 4 ]BVD-15 for Y 1 R and Y 4 R competition binding experiments was also demonstrated in intact cells. The nature of the label was shown to be critical with replacement of sCy5 by the more hydrophobic Cy5.5 resulting in a switch from Y 1 R antagonist to Y 1 R partial agonist.

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Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization

Cited by 48 publications

References 77 publications

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Discovery of a Novel Insect Neuropeptide Signaling System Closely Related to the Insect Adipokinetic Hormone and Corazonin Hormonal Systems

Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y₁R and Y₄R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15

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Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization

Cited by 48 publications

References 77 publications

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Different expression patterns of sperm motility-related genes in testis of diploid and tetraploid cyprinid fish†

Discovery of a Novel Insect Neuropeptide Signaling System Closely Related to the Insect Adipokinetic Hormone and Corazonin Hormonal Systems

Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15

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Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y₁R and Y₄R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15