Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery

Huang, Yi‐Cheng; Li, Rou‐Ying; Chen, Jiun-Yu; Chen, Jen‐Kun

doi:10.1016/j.carbpol.2015.11.072

Cited by 95 publications

(50 citation statements)

References 61 publications

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“…From Figure , it would reach rapidly to the effective concentration of drug owing to the burst release in the course of 12 h and keep the release sustained then after. Several studies reported the sustained release of MTX‐loaded nanoparticles,and biphasic release of gentamicin from chitosan/fucoidan nanoparticles revealing that our results were in agreement with these reports …”

Section: Discussionsupporting

confidence: 93%

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Wang

Kankala

Chen

et al. 2018

J Biomedical Materials Res

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Herein, we fabricated the novel drug delivery system based on the self‐assembly of two polyelectrolytes, poly‐allylamine hydrochloride (PAH) and fucoidan, as the polycation and polyanion, respectively, under mild conditions for cancer therapeutics. Furthermore, the designed polyelectrolyte complex nanoparticles as well as the methotrexate (MTX) disodium salt‐loaded composites were systematically characterized using various techniques. The MTX loading in the nanoparticles was confirmed by zeta potential values that changed from −36.2 ± 2.2 to −28.3 ± 3.1 mV at a loading amount of 13.3 ± 1.2%. Furthermore, the obtained eventual particle sizes of nanoparticles were various with different concentrations and ratios of polyelectrolytes. The particle size also has increased from 130 ± 2.6 to 162.9 ± 2.3 nm after loading MTX. The drug release investigations in vitro at a pH value of 6.0 (acid environment) showed that the release of MTX was sustained in the conditions provided. Finally, we investigated the anticancer efficacy of MTX‐loaded nanoparticles on MCF‐7 cells and HeLa cells and the satisfactory results were obtained. Together, these self‐assembled PAH/fucoidan nanoparticles with sustained drug release property will become the promising delivery system for cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 339–347, 2019.

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Section: Discussionsupporting

confidence: 93%

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Wang

Kankala

Chen

et al. 2018

J Biomedical Materials Res

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“…[78][79][80][81] Gentamicin undergoes controlled release from CS/fucoidan NPs, which renders the NPs into a multiple-function drug delivery system with antibacterial and antioxidant activities that can be used to treat pneumonia. 82 In addition, CS-coated alginate NPs increase the ability of daptomycin to permeate the limbal epithelium of the eye and also increase its ocular accumulation and effect duration. The key features of a drug delivery system are biodegradability, biocompatibility, controlled drug transport, and delivery to the target tissue.…”

Section: Np-based Antibiotic Delivery Systemsmentioning

confidence: 99%

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang¹,

Hu²,

Shao³

2017

IJN

2,929

1,792

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Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed.

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“…Another report illustrated that gentamicin‐loaded chitosan/fucoidan NPs were developed to provide multiple antimicrobial capabilities against K . pneumoniae , representing an improvement in antimicrobial efficacy (Huang et al, ). Synthetic polymers have been used for targeted delivery of antibiotics to macrophages for the treatment of intracellular ESKAPE infections.…”

Section: Treatments For Eskape Pathogensmentioning

confidence: 99%

Nanodelivery strategies for the treatment of multidrug‐resistant bacterial infections

Jiang

Lin

Taggart

et al. 2018

J of Interdiscip Nanomed

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One of the most important health concerns in society is the development of nosocomial infections caused by multidrug‐resistant pathogens. The purpose of this review is to discuss the issues in current antibiotic therapies and the ongoing progress of developing new strategies for the treatment of ESKAPE pathogen infections, which is acronymized for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. We not only examine the current issues caused by multidrug resistance but we also examine the barrier effects such as biofilm and intracellular localization exploited by these pathogens to avoid antibiotic exposure. Recent innovations in nanomedicine approaches and antibody antibiotic conjugates are reviewed as potential novel approaches for the treatment of bacterial infection, which ultimately may expand the useful life span of current antibiotics.

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Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery

Cited by 95 publications

References 61 publications

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

Poly‐allylamine hydrochloride and fucoidan‐based self‐assembled polyelectrolyte complex nanoparticles for cancer therapeutics

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Nanodelivery strategies for the treatment of multidrug‐resistant bacterial infections

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