Bioverfahrensentwicklung

Storhas, Winfried

doi:10.1002/9783527673834

Cited by 19 publications

(20 citation statements)

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“…The material surface, which constitutes the substratum of the biofilm, affects not only the vitality and stability of the culture, but probably also has an impact on its productivity. Thus, the question is which material surfaces and surface structures are best for long-term stability and productivity of biofilms [31] Glycolic acid Pseudomonas diminuta Trickle bed reactor [37] Octanol Pseudomonas putida PpS81 (R) Membrane reactor [36] Pyruvate Acetobacter xylinum (R) Stirred tank reactor [34] Tryptophan synthase Escherichia coli PHL644 Shake flask [32] polymeric matrix can also be a disadvantage for mass transfer. Although the observed 3D architecture with channels and pores in mature biofilms promotes the cell supply, it also influences the stability of the system [5].…”

Section: Biofilms In Biotechnologymentioning

confidence: 99%

“…Hence, biofilms have been successfully applied in microbiological treatment and remediation for years, e.g., in wastewater treatment and removal of heavy metals from contaminated soil [36]. Furthermore, continuous efforts in the establishment of biofilm processes for the production of valuable substances are done [31,[37][38][39][40].…”

Section: Biofilms In Biotechnologymentioning

confidence: 99%

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Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

et al. 2015

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For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.

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Section: Biofilms In Biotechnologymentioning

confidence: 99%

Section: Biofilms In Biotechnologymentioning

confidence: 99%

Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

et al. 2015

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“…Aus wirtschaftlichen Gründen, d. h. hohe Standzeiten, geringer Personal-aufwand bei gleichzeitig hoher Prozessautomatisierung etc., werden in der industriellen Anwendung vornehmlich kontinuierliche Verfahren angestrebt. B. in der Abwasserbehandlung und Bindung von Schwermetallen [36]. Als robuste Systeme, die gleichzeitig eine schonende Zellrückhaltung ermöglichen, können Biofilme als Produktionssysteme Nachteile der kontinuierlichen Betriebsart verringern [31 -33].…”

Section: Biofilme In Der Biotechnologieunclassified

Biotechnologie und Bioverfahrenstechnik – Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen

Al‐Kaidy

Duwe

Huster

et al. 2014

Chemie Ingenieur Technik

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Biotechnologie und die mit ihr verbundenen technischen Prozesse prägen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und täglichen Gebrauchsgütern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verständnis zellulärer Vorgänge können mittlerweile Produktionsstämme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik können so eine Vielzahl von Bulk‐ und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.

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“…For decades, biofilms have been successfully used in bioremediation, mainly in the treatment of wastewater and off-gas (Storhas, 2013;Tsoligkas et al, 2011). Recently, the interest in productive biofilms has greatly increased, since the application of biofilm technology has been extended to the production of bulk and fine chemicals (Gross, Schmid, & Buehler, 2012;Rosche, Li, Hauer, Schmid, & Buehler, 2009).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of productive biofilms for continuous lactic acid production

Cuny

Pfaff

Luther

et al. 2019

Biotech & Bioengineering

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In white biotechnology research, the putative superiority of productive biofilms to conventional biotransformation processes based on planktonic cultures has been increasingly discussed in recent years. In the present study, we chose lactic acid production as a model application to evaluate biofilm potential. A pure culture of Lactobacillus bacteria was grown in a tubular biofilm reactor. The biofilm system was cultivated monoseptically in a continuous mode for more than 3 weeks. The higher cell densities that could be obtained in the continuous biofilm system compared with the planktonic culture led to a significantly increased space-time yield. The productivity reached 80% of the maximum value 10 days after start-up and no subsequent decline was observed, confirming the suitability of the system for long-term fermentation. The analysis of biofilm performance revealed that productivity increases with the flow velocity. This is explained by the reduced retention time of the liquid phase in the reactor, and, thus, a minor pH drop caused by the released lactic acid. At low flow velocities, the pH drops to a value where growth and production are significantly inhibited. The biofilm was visualized by magnetic resonance imaging to analyze biofilm thickness. To deepen the understanding of the biofilm system, we used a simple model for cell growth and lactic acid production. K E Y W O R D Slactic acid production, long-term fermentation, magnetic resonance imaging, productive biofilm, simulation, tubular biofilm reactor

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Bioverfahrensentwicklung

Cited by 19 publications

References 0 publications

Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

Biotechnology and Bioprocess Engineering – From the First Ullmann's Article to Recent Trends

Biotechnologie und Bioverfahrenstechnik – Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen

Evaluation of productive biofilms for continuous lactic acid production

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