Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa

Kıran, İsmail; Akar, Tamer; Gorgulu, Asli; Kazaz, Cavit

doi:10.1007/s10529-005-7868-y

Cited by 9 publications

(4 citation statements)

References 11 publications

(12 reference statements)

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“…The biotransformation of (+)-curdione (66) was also investigated [29] under the same conditions and the same three metabolites were found, i.e. two epimeric secondary alcohols (67 and 68) and one spirocyclic glycol lactone (69). Site-specific hydroxylation and epoxidation of (+)-curdione 66 75:…”

Section: Fermentation Of Cedrolmentioning

confidence: 93%

“…Germacrone (64) yielded the metabolite 61, along with a very unstable allylic alcohol (65). Incubation of 66 with Aspergillus niger yielded two hydroxylated ketones (67 and 68) and a spirolactone (69), as represented in Scheme 12. The biotransformation of (+)-curdione (66) was also investigated [29] under the same conditions and the same three metabolites were found, i.e.…”

Section: Fermentation Of Cedrolmentioning

confidence: 99%

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Microbial Transformation of Sesquiterpenoids

Bhatti

Zubaır

Rasool

et al. 2009

Natural Product Communications

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Biotransformations are useful methods for producing medicinal and agricultural chemicals from both active and inactive natural products with the introduction of chemical functions into remote sites of the molecules. Research on microbial biotransformations of commonly available sesquiterpenoids into more valuable derivatives has always been of interest because of their economical potential to the perfume, food, chemical and pharmaceutical industries. Fungal transformations of sesquiterpenoids have been less frequently studied compared with many other natural products. In recent years, however, much attention has been given to the exploitation of new products with enhanced biological activity using microorganisms. This review, covering the period from 1990 to 2006, summarizes our knowledge of the biotransformations of sesquiterpenoids by various fungi. Such transformations could lead to the discovery of new reaction pathways that might be useful in the design of new value-added products.

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Section: Fermentation Of Cedrolmentioning

confidence: 93%

Section: Fermentation Of Cedrolmentioning

confidence: 99%

Microbial Transformation of Sesquiterpenoids

Bhatti

Zubaır

Rasool

et al. 2009

Natural Product Communications

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“…A portion of protein is a component of the pore system with an outside diameter of 40-70Å embedded in the matrix of the wall. 20 This fungus has recently been used for not only the microbial hydroxylation of a sesquiterpene, diisophorone, 21 but also the removal of Cr(VI), 22 Pb(II) and Cu(II) ions from aqueous solutions. 23 To our knowledge, it has not been used for the removal of dyes from aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

Biosorption potential of Neurospora crassa cells for decolorization of Acid Red 57 (AR57) dye

Akar

Demir

Kıran

et al. 2006

J of Chemical Tech & Biotech

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Biosorption of Acid Red 57 (AR57) on to Neurospora crassa was studied with variation of pH, contact time, biosorbent and dye concentrations and temperature to determine equilibrium and kinetic models. The AR57 biosorption was fast and equilibrium was attained within 40 min. Langmuir, Freundlich and Dubinin-Radushkevich (D-R) isotherm models were applied to experimental equilibrium data for AR57 biosorption at various temperatures. The equilibrium data fitted very well to all the equilibrium models in the studied concentration range of AR57. Maximum biosorption capacity (q max ) of AR57 on to N. crassa was 2.16 × 10 −4 mol g −1 at 20 • C. The kinetics of biosorption of AR57 were analyzed and rate constants were derived. The overall biosorption process was best described by a pseudo-second-order kinetic model. The changes in Gibbs free energy, enthalpy and entropy of biosorption were also evaluated for the biosorption of AR57 on to N. crassa. The results indicate that the biosorption was spontaneous and exothermic in nature.

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“…The fungus C. aphidicola promotes hydroxylations in different classes of organic compounds and has been widely used in biotransformations of kaurane diterpenes [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Di-And Tri-Hydroxylated Kaurane Derivatives From Microbial Transformation Of Ent-Kaur-16-En-19-Ol By Cephalosporium Aphidicola And Their Allelopathic Activity On Lactuca Sativa (Lettuce)

2009

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The use of microorganisms to induce chemical modifications in organic molecules is a very useful tool in organic synthesis, to obtain biologically active substances. The fungus Cephalosporium aphidicola is known by its ability to hydroxylate several skeleton positions of many classes of organic compounds. In this work, the microbial transformation of ent-kaur-16-en-19-ol (1) by C. aphidicola, afforded two hydroxylated compounds, ent-kauran-16b,19-diol (2) and ent-kauran-16b,17,19-triol (3). Their structures were established by 1D and 2D-NMR studies. Both compounds were tested for their action on the growth of radical and shoot of Lactuca sativa.

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Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa

Cited by 9 publications

References 11 publications

Microbial Transformation of Sesquiterpenoids

Microbial Transformation of Sesquiterpenoids

Biosorption potential of Neurospora crassa cells for decolorization of Acid Red 57 (AR57) dye

Di-And Tri-Hydroxylated Kaurane Derivatives From Microbial Transformation Of Ent-Kaur-16-En-19-Ol By Cephalosporium Aphidicola And Their Allelopathic Activity On Lactuca Sativa (Lettuce)

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