Biotransformation of isofraxetin-6- O - β - d -glucopyranoside by Angelica sinensis (Oliv.) Diels callus

Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential

“…The 1 H NMR spectrum showed two meta-coupled protons of an aromatic ring at d , and C-8a and from OCH 3 -7 to C-7 were further conrmed the 5,6-dioxo-7-methoxycoumarin moiety. 6 Furthermore, the location of the another methoxy group of a tetrasubstituted aromatic ring at C-3 0 (d C 149.8) was further conrmed by the HMBC cross-peaks of H-2 0 to C-3 0 and C-4 0 (d C 136.1), H-6 0 to C-4 0 and C-5 0 (d C 147.1), and OCH 3 -3 0 to C-3 0 . The fragments of C-7 0 (d C 78.8)-C-8 0 (d C 79.9)-C-9 0 (d C 62.3) were observed by COSY analysis (Fig.…”

“…The known compounds, simplidin (7), 9 5-O-demethylbilagrewin (8), 14 malloapelin C (9), 15 syringaresinol (10), 16 pinoresinol (11), 16 3-(a,4-dihydroxy-3-methoxy-benzyl)-4-(4-hydroxy-3methoxybenzyl)tetrahydrofuran (12), 17 secoisolariciresinol (13), 18 rosmarinic acid (14), 19 clinopodic acid A (15), 19 cis-7hydroxycalamenene (16), 20 trans-7-hydroxycalamenene (17), 20 7hydroxycadalene (18), 21 33 27-O-trans-caffeoylcylicodiscic acid (36), 11 3-epi-betulinic acid (37), 34 3-epi-betulinic acid acetate (38), 35 betulonic acid (39), 36 lupeol (40), 37 oleanolic acid (41), 38 3b-hydroxysitost-5-en-7-one (42), 39 ergosterol peroxide (43), 40 Table 1. The results indicated that 3a,27-di-O-trans-caffeoylbetulinic acid (6) and secoisolariciresinol (13) displayed weak but selective cytotoxicity toward NCI-H460 and HepG2 cancer cell lines, respectively. While three cardenolides: strophanthojavoside (31) and ascleposide (32) with IC 50 < 1 mM and strophalloside (33) displayed selective cytotoxicity to NCI-H460 with IC 50 0.62 AE 0.06 mM as well.…”

“…In this study, we investigated the stem of R. formosana and the remaining fractions of the root of R. formosana. From these two parts led to the isolation of six new compounds including three lignanoids: reevesiacoumarin (1), reevesic acid (2), and reevesilignan (3), and three terpenoids: reevesiterpenol A (4), reevesiterpenol B (5), and 3a,27-di-O-trans-caffeoylbetulinic acid (6) (Fig. 1), along with 40 known compounds.…”

“…The bioassay indicated three cardenolides: strophanthojavoside (31) and ascleposide (32) with IC 50 < 1 mM and strophalloside (33) displayed selective cytotoxicity to NCI-H460 with IC 50 0.62 AE 0.06 mM as well. 3a,27-Di-O-trans-caffeoylbetulinic acid (6) and secoisolariciresinol (13) also showed weak but selective cytotoxicity to NCI-H460 and HepG2 cancer cell lines, respectively. All the structures were elucidated and conrmed through the 1D and 2D spectroscopic techniques.…”

Indole-3-Carboxylic Acid From the Endophytic Fungus Lasiodiplodia pseudotheobromae LPS-1 as a Synergist Enhancing the Antagonism of Jasmonic Acid Against Blumeria graminis on Wheat

“…ST4, Streptomyces sp. CT37, Aeromicrobium ponti LGMB491, Janthinobacterium lividum , Clitocybe nuda LA82, Angelica sinensis callus, and Marinomonas sp., has inhibitory effects on the growth of Sporisorium scitamineum , Ustilago maydis , Candida albicans ATCC 10231, Staphylococcus aureus , and Batrachochytrium dendrobatidis JEL215, on zoospore germination of Phytophthora capsici PCM81, on neuroinflammation, and on the biofilm formation of Vibrio cholerae O1, respectively ( Brucker et al., 2008 ; Chen et al., 2012 ; Rajalaxmi et al., 2016 ; Gos et al., 2017 ; Zhou et al., 2017 ; Liu et al., 2020 ; Fang et al., 2020 ). However, other reports about indole-3-carbaldehyde did not indicate its antimicrobial activity against pathogens.…”