Preventive agents for neurodegenerative diseases from resin of Dracaena cochinchinensis attenuate LPS-induced microglia over-activation

Tang, Yingzhan; Su, Guangyue; Li, Ning; Li, Wenjie; Chen, Gang; Chen, Ru; Zhou, Di; Hou, Yue

doi:10.1007/s11418-018-1266-y

Cited by 20 publications

(7 citation statements)

References 49 publications

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“…The first group includes the flavonoids 1 – 4 and liquiritigenin, and the stilbene resveratrol, among which the flavanes are well known constituents of the stem and red resin of Dracaena cochinchinensis (Agavaceae) [23,27,29,30,39,46]. The red resinous material, known as Chinese dragon’s blood, is a popular folk medicine used for treatment of fractures, wounds, stomach ulcers, etc.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae

et al. 2019

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Propolis produced by the stingless bee Lisotrigona cacciae was studied for the first time. Using different chromatographic procedures, a total of eighteen constituents (phenols and triterpenes) were isolated, among which flavane 1 , homoisoflavanes 2 – 4 , and xanthones 5 and 6 were new for propolis. Propolis extract was also characterized by gas chromatography/mass spectrometry and other fifteen constituents were identified. The xanthone α -mangostin ( 8 ) demonstrated significant activity against Staphylococcus aureus with MIC and MBC 0.31 μg/ml, followed by 7,4'-dihydroxy-5-methoxy-8-methylflavane ( 1 ) with MIC 78 μg/ml and MBC 156 μg/ml. 10,11- Dihydroxydracaenone C ( 4 ), a component bearing ortho -hydroxyl groups, was the only compound displaying radical scavenging ability. Triple botanical origin of the sample was defined, consisting of Dracaena cochinchinensis , Cratoxylum cochinchinense and Mangifera indica . D . cochinchinensis is a new resin source of propolis.

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Section: Resultsmentioning

confidence: 99%

Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae

et al. 2019

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“…Through SAR, the relationship between the chemical structure of compounds and its biological activity can be assessed, and easily determine the particular chemical group inducing a particular biological effect. In Chinese dragon's blood chalcone, homoisoflavanone and flavone were found to suppress the neuroinflammatory process in neurodegenerative diseases [130]. By SAR analysis, it was observed that the active moiety (1-(2,4-dimethoxy-phenyl)-propenone), substituent position in the phenyl ring was the key component in imparting the anti-inflammatory effect of pyrazole chalcones [131].…”

Section: Phytochemicals Inhibiting Tnf-α For Lowering the Neuroinflammentioning

confidence: 99%

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Subedi

Lee

Madiha

et al. 2020

IJMS

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Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p55 and p75, respectively. Normally, the functions of soluble TNF-α-induced TNFR1 activation are reported to be pro-inflammatory and apoptotic. While TNF-α mediated TNFR2 activation has a dual role. Several synthetic drugs used as inhibitors of TNF-α for diverse inflammatory diseases possess serious adverse effects, which make patients and researchers turn their focus toward natural medicines, phytochemicals in particular. Phytochemicals targeting TNF-α can significantly improve disease conditions involving TNF-α with fewer side effects. Here, we reviewed known TNF-α inhibitors, as well as lately studied phytochemicals, with a role in inhibiting TNF-α itself, and TNF-α-mediated signaling in inflammatory diseases focusing mainly on CNS disorders.

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“…Anti-inflammatory, Cytotoxic, Antipyretic [25,33,34] Heliciopsis terminalis (Kurz) Sleumer (Proteaceae)…”

Section: Discussionmentioning

confidence: 99%

Exploring in vitro anti-proliferative and anti-inflammatory activities of Prasachandaeng remedy, and its bioactive compounds

Prommee

Itharat

Thongdeeying

et al. 2022

BMC Complement Med Ther

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Background Prasachandaeng (PSD) remedy has been empirically used in Thai traditional medicine to treat fever in bile duct and liver and cancer patients through Thai folk doctors. However, there have been no scientific reports on the bioactive compounds and bioactivities related to inflammation-associated carcinogenesis or cytotoxicity against cancer cell lines. In this study, we investigated the chemical content of the remedy, and evaluated its cytotoxic activity against two cancer cell lines in comparison with a non-cancerous cell line and determined tumor necrosis factor-alpha (TNF-α) production in a murine macrophage cell line (RAW 264.7) to evaluate anti-inflammatory activity. A novel HPLC method was used for quality control of its chemical content. Methods Pure compounds from the EtOH extract of D. cochinchinensis were isolated using bioassay-guided fractionation and chemical content of the PSD remedy was determined using HPLC. The cytotoxic activity against the hepatocarcinoma cell line (HepG2) and cholangiocarcinoma cell line (KKU-M156), in comparison with non-cancerous cell line (HaCaT), were investigated using antiproliferative assay (SRB). The anti-inflammatory activity measured by TNF-α production in RAW 264.7 was determined using ELISA. Results All crude extracts and isolated compounds exhibited significant differences from vincristine sulfate (****p < 0.0001) in their cytotoxic activity against HepG2, KKU-M156, and HaCaT. The PSD remedy exhibited cytotoxic activity against HepG2 and KKU-M156 with IC50 values of 10.45 ± 1.98 (SI = 5.3) and 4.53 ± 0.74 (SI = 12.2) µg/mL, respectively. Some constituents from C. sappan, D. cochinchinensis, M. siamensis, and M. fragrans also exhibited cytotoxic activity against HepG2 and KKU-M156, with IC50 values less than 10 µg/mL. The isolated compounds, i.e., Loureirin B (1), 4-Hydroxy-2,4’-dimethoxydihydrochalcone (2), and Eucomol (3) exhibited moderate cytotoxicity against two cancer cell lines. None of the crude extracts and isolated compounds showed cytotoxicity against HaCaT. D. cochinchinensis and PSD remedy exhibited higher anti-inflammatory activity measured as TNF-α production than acetaminophen. Conclusion The findings provide evidence of bioactivity for EtOH extracts of PSD remedy and the isolated compounds of D. Cochinchinensis. The results consistent the use clinical activity and use of PSD remedy as a antipyretic treatment for liver and bile duct cancer patients by Thai traditional practitioners.

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Preventive agents for neurodegenerative diseases from resin of Dracaena cochinchinensis attenuate LPS-induced microglia over-activation

Cited by 20 publications

References 49 publications

Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae

Phytochemical analysis of Vietnamese propolis produced by the stingless bee Lisotrigona cacciae

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases

Exploring in vitro anti-proliferative and anti-inflammatory activities of Prasachandaeng remedy, and its bioactive compounds

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