Biotransformation of Flavonoids by Terrestrial and Marine Microorganisms

Matos, Iara Lisboa de; Nitschke, Monika; Fonseca, Luís P.; Porto, André Luiz Meleiro

doi:10.1002/9781119143802.ch87

Cited by 3 publications

(4 citation statements)

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“…(ii) The second way is biotransformation, which allows modifying the structure of organic molecules with specific enzymes, enabling the catalysis of different reactions [11], including hydroxylation, dehydroxylation, methylation and demethoxylation. This method is a great alternative to organic synthesis and offers the advantage of high stereoselectivity [12].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

et al. 2022

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Actinobacteria isolated from untapped environments and exposed to extreme conditions such as saltpans are a promising source of novel bioactive compounds. These microorganisms can provide new molecules through either the biosynthetic pathway or the biotransformation of organic molecules. In the present study, we performed a chemical metabolic screening of secondary metabolites secreted by the new strain CG3, which was isolated from a saltpan located in the Sahara of Algeria, via high-performance liquid chromatography coupled with high-resolution mass spectrometry (HPLC-ESI-HRMS). The results indicated that this strain produced five new polyene macrolactams, kenalactams A–E, along with two known compounds, mitomycin C and 6″-hydroxy-4,2′,3′,4″ tetramethoxy-p-terphenyl. Furthermore, the CG3 isolate could have excellent properties for converting the aglycone isoflavone glycitein to the compounds 6,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one (50) and 6,7-dimethoxy-3-phenylchromen-4-one (54), and the isoflavone genistein can be converted to 5,7-dimethoxy-3-(4-methoxyphenyl)chromen-4-one (52). Docking studies and molecular dynamics simulations indicated that these three isoflavones, generated via biotransformation, are potent inhibitors of the target protein aromatase (CYP19A1); consequently, they can be used to prevent breast cancer risk in postmenopausal women.

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Section: Introductionmentioning

confidence: 99%

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

et al. 2022

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“…Currently, hundreds of enzymes have industrial applications in biocatalysis and biotransformation processes. The source of more than half of those enzymes is fungal strains, more than a third are derived from bacteria, while the others come from animals and plants [17].…”

Section: Introductionmentioning

confidence: 99%

“…These organisms show the ability to live in an environment with variable temperature, extreme pH values, high salt concentration, and high pressure. For this reason, they are characterized by the production of a variety of unique enzymes with a wide range of potential industrial applications [17]. Marine microorganisms are able to carry out various modifications of flavonoid compounds, e.g., hydroxylation, hydrolysis of glycosidic bonds, or reduction of chalcones [17,25].…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, they are characterized by the production of a variety of unique enzymes with a wide range of potential industrial applications [17]. Marine microorganisms are able to carry out various modifications of flavonoid compounds, e.g., hydroxylation, hydrolysis of glycosidic bonds, or reduction of chalcones [17,25]. The last reaction is of particular interest because it leads to highly bioactive dihydrochalcones with possible use as sweeteners in the food industry [17,26,27].…”

Section: Introductionmentioning

confidence: 99%

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The Callus of Phaseolus coccineus and Glycine max Biotransform Flavanones into the Corresponding Flavones

2020

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In vitro plant cultures are gaining in industrial importance, especially as biocatalysts and as sources of secondary metabolites used in pharmacy. The idea that guided us in our research was to evaluate the biocatalytic potential of newly obtained callus tissue towards flavonoid compounds. In this publication, we describe new ways of using callus cultures in the biotransformations. In the first method, the callus cultures grown on a solid medium are transferred to the water, the reaction medium into which the substrate is introduced. In the second method, biotransformation is carried out on a solid medium by growing callus cultures. In the course of the research, we have shown that the callus obtained from Phaseolus coccineus and Glycine max is capable of converting flavanone, 5-methoxyflavanone and 6-methoxyflavanone into the corresponding flavones.

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Screening of Beta-glucosidase inhibitors and their Chemical Profiles from Marine sediment Bacteria

et al. 2022

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Biotransformation of Flavonoids by Terrestrial and Marine Microorganisms

Cited by 3 publications

References 50 publications

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

Metabolic Profile, Biotransformation, Docking Studies and Molecular Dynamics Simulations of Bioactive Compounds Secreted by CG3 Strain

The Callus of Phaseolus coccineus and Glycine max Biotransform Flavanones into the Corresponding Flavones

Screening of Beta-glucosidase inhibitors and their Chemical Profiles from Marine sediment Bacteria

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