Biotransformation an Polymer‐Peptid‐Konjugaten – ein universelles Werkzeug zur Mikrostrukturkontrolle

Kühnle, Hans; Börner, Hans G.

doi:10.1002/ange.200805768

Cited by 20 publications

(11 citation statements)

References 40 publications

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“…The combination of peptides and synthetic polymers results in the formation of hybrid structures, merging unique attributes of the biological and the synthetic elements. [124][125][126][127][128][129] For biological applications, the close resemblance of mf-PEG to the PEG homopolymer is a bonus. Frey and Obermeier recently demonstrated an efficient route to PEG-based bioconjugates with multiple peptides attached homogeneously to the mf-PEG backbone.…”

Section: High-capacity Peptide Conjugationmentioning

confidence: 99%

Multifunctional Poly(ethylene glycol)s

et al. 2011

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In the rapidly evolving multidisciplinary field of polymer therapeutics, tailored polymer structures represent the key constituent to explore and harvest the potential of bioactive macromolecular hybrid structures. In light of the recent developments for anticancer drug conjugates, multifunctional polymers are becoming ever more relevant as drug carriers. However, the potentially best suited polymer, poly(ethylene glycol) (PEG), is unfavorable owing to its limited functionality. Therefore, multifunctional linear copolymers (mf-PEGs) based on ethylene oxide (EO) and appropriate epoxide comonomers are attracting increased attention. Precisely engineered via living anionic polymerization and defined with state-of-the-art characterization techniques-for example real-time (1)H NMR spectroscopy monitoring of the EO polymerization kinetics-this emerging class of polymers embodies a powerful platform for bio- and drug conjugation.

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Section: High-capacity Peptide Conjugationmentioning

confidence: 99%

Multifunctional Poly(ethylene glycol)s

et al. 2011

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“…Under aqueous conditions, the conjugates were observed to interdigitate with peptide segments and form fi brils up to 1 μ m in length. Kühnle and Börner [ 115 ] also reported a similar construct with only one peptide chain per polymer. This material was designed as a switchable system, in which fi bril formation could be controlled enzymatically.…”

Section: Peptides As Self-assembling Unitsmentioning

confidence: 99%

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

Borchmann

Carberry

Weck

2013

Macromol. Rapid Commun.

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Polymer-protein conjugates are biohybrid macromolecules derived from covalently connecting synthetic polymers with polypeptides. The resulting materials combine the properties of both worlds: chemists can engineer polymers to stabilize proteins, to add functionality, or to enhance activity; whereas biochemists can exploit the specificity and complexity that Nature has bestowed upon its macromolecules. This has led to a wealth of applications, particularly within the realm of biomedicine. Polymer-protein conjugation has expanded to include scaffolds for drug delivery, tissue engineering, and microbial inhibitors. This feature article reflects upon recent developments in the field and discusses the applications of these hybrids from a biomaterials standpoint.

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“…wässrigen Medien zu erhalten. Enzymatisch induzierte Anordnung wurde ebenfalls demonstriert [178] sowie zerstçrungsfreie chemische Modifizierung nach Aggregation. [179] Dieselbe Gruppe führte Oligothiophen-Einheiten ein [180] mit dem endgültigen Ziel der kontrollierten Anordnung von Nanostrukturen zu molekularen Drähten.…”

Section: Funktionale Materialien Aus Oligomer/polymer-peptid-hybridenunclassified

Modulares Design in natürlichen und biomimetischen elastischen Materialien

Kushner

Guan

2011

Angewandte Chemie

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Unter Verwendung der zwanzig natürlichen Aminosäuren als Grundbausteine haben biologische Systeme während der Jahrmillionen unter evolutionärem und umweltbedingtem Druck stabile und leichte Peptid‐basierte Materialien entwickelt. Diese Materialien übertreffen ihre synthetischen Gegenstücke in mehrfacher Hinsicht: 1) Multifunktionalität/Abstimmbarkeit, 2) Anpassungsfähigkeit/Reizempfindlichkeit, 3) Synthese und Weiterverarbeitung bei Umgebungsbedingungen in wässrigem Medium und 4) Wiederverwertung und biologische Abbaubarkeit. Diese besonderen Eigenschaften können durch eine “Bottom‐up”‐Synthese und die hierarchische Organisation auf verschiedenen Längenskalen erreicht werden. Das Arbeitsgebiet der “Biomimikry” beschäftigt sich damit, die Gestaltungsprinzipien natürlicher Materialien und deren molekulare Bausteine aufzuklären und zu kopieren. Hier beschreiben wir, was bereits über Struktur und molekulare Mechanismen natürlicher polymerer Materialien erforscht wurde, sowie den Fortschritt in Richtung synthetischer “Nachbildungen” dieser bemerkenswerten Systeme.

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Biotransformation an Polymer‐Peptid‐Konjugaten – ein universelles Werkzeug zur Mikrostrukturkontrolle

Cited by 20 publications

References 40 publications

Multifunctional Poly(ethylene glycol)s

Multifunctional Poly(ethylene glycol)s

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

Modulares Design in natürlichen und biomimetischen elastischen Materialien

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