Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery

Wu, Li Bang; Hsu, Jen Fang; Shigeto, Shinsuke; Hsu, Hsin-Yun

doi:10.1016/j.actbio.2015.05.006

Cited by 15 publications

(17 citation statements)

References 51 publications

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“…Up to now, commercially available bridged silanes containing disulfide bonds were only of two kinds: 1) bis(triethoxysilyl propyl) disulfide (BTEPDS, (H 5 C 2 O) 3 Si(CH 2 ) 3 SS(CH 2 ) 3 Si(OC 2 H 5 ) 3 ) or bis(trimethoxysilyl propyl) disulfide (BTMPDS, (H 3 CO) 3 Si(CH 2 ) 3 SS(CH 2 ) 3 Si(OCH 3 ) 3 ) and 2) bis(3‐triethoxysilyl propyl) tetrasulfide (BTEPTS, (H 5 C 2 O) 3 Si(CH 2 ) 3 SSSS(CH 2 ) 3 Si(OC 2 H 5 ) 3 ) (Figure a,b). Other bridged silanes containing disulfide bonds are synthesized by smart molecular design, as shown in Figure c–h . In the case of MONs with the different bridged groups of “(CH 2 ) 3 S 2 (CH 2 ) 3 ”, “(CH 2 ) 3 S 4 (CH 2 ) 3 ”, or other groups with disulfide bond in Figure , we abbreviate them into disulfide‐bridged MONs.…”

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

“…Molecular formulae of bridged silanes containing disulfide bond: a,b) commercially available and c–h) smartly designed …”

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

“…Hsu and co‐workers synthesized NPs with a combined bis(propylamide‐ethyl)disulfide‐bridged and aminopropyl‐modified organosilica scaffold in the NH 3 ·H 2 O–ethanol–water system by co‐condensation of 3‐aminopropyltrimethoxysilane (APTMS) and the silane in Figure f at room temperature (Figure B). The S/Si molar ratio increased from the particle surface (1/8.7) to the core (1/2) . Croissant et al prepared disulfide‐bridged nanospheres containing two‐photon electron donor (2PS) and porphyrin (POR) groups in CTAB–NaOH–water system at 80 °C for two photon‐excited (TPE) imaging and therapy (Figure C) .…”

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

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Disulfide‐Bridged Organosilica Frameworks: Designed, Synthesis, Redox‐Triggered Biodegradation, and Nanobiomedical Applications

Kleitz

et al. 2018

Adv Funct Materials

155

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Over the past few years, silica‐based nanotheranostics have demonstrated their great potential for nano/biomedical applications. However, the uncontrollable and difficult degradability of their pure silica framework and long‐time in vivo retention still cause severe and unpredictable toxicity risks. Therefore, it is highly desirable to design and synthesize materials with safer framework structures and compositions. To this aim, the introduction of disulfide bonds into the silica framework can not only maintain high stability in physiological conditions, but also achieve a stimuli‐responsive biodegradation triggered by intracellular reducing microenvironment in living cells, especially in cancer cells. Once nanotheranostics with disulfide (i.e., thioether)‐bridged silsesquioxane framework are taken up by tumor cells via passive or active targeting, the disulfide bonds in the hybrid silica matrix can be cleaved by a high concentration of intracellular glutathione, enabling redox‐triggered biodegradation of the nanosystems for both concomitant release of the loaded therapeutic cargo and in vivo clearance. It is envisioned that such hybrid materials comprised of disulfide‐bridged silsesquioxane frameworks can become promising responsive and biodegradable nanotheranostics. This review summarizes the recent advances in the synthesis of hybrid organosilicas with disulfide‐bridged silsesquioxane frameworks, and discuss their redox‐triggered biodegradation behaviors combined with their biocompatibility and nanobiomedical applications.

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Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

“…Molecular formulae of bridged silanes containing disulfide bond: a,b) commercially available and c–h) smartly designed …”

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

Section: Controlled Synthesis Of Hybrid Nanomaterials With Disulfide‐mentioning

confidence: 99%

See 2 more Smart Citations

Disulfide‐Bridged Organosilica Frameworks: Designed, Synthesis, Redox‐Triggered Biodegradation, and Nanobiomedical Applications

Kleitz

et al. 2018

Adv Funct Materials

155

View full text Add to dashboard Cite

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“…Copyright 2014 Wiley decomposition-assembly of micelles show significantly higher cytotoxicity. It should be mentioned that some works also focus on developing nano-platforms with low [37] or tunable [38] stimuli-responsive cytotoxicity.…”

Section: Intracellular-responsive Cytotoxicitymentioning

confidence: 99%

Recent advances in cell imaging and cytotoxicity of intracellular stimuli-responsive nanomaterials

Zhang

Gao

2015

Science Bulletin

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Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles

2017

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The biorelated degradability and clearance of siliceous nanomaterials have been questioned worldwide, since they are crucial prerequisites for the successful translation in clinics. Typically, the degradability and biocompatibility of mesoporous silica nanoparticles (MSNs) have been an ongoing discussion in research circles. The reason for such a concern is that approved pharmaceutical products must not accumulate in the human body, to prevent severe and unpredictable side-effects. Here, the biorelated degradability and clearance of silicon and silica nanoparticles (NPs) are comprehensively summarized. The influence of the size, morphology, surface area, pore size, and surface functional groups, to name a few, on the degradability of silicon and silica NPs is described. The noncovalent organic doping of silica and the covalent incorporation of either hydrolytically stable or redox- and enzymatically cleavable silsesquioxanes is then described for organosilica, bridged silsesquioxane (BS), and periodic mesoporous organosilica (PMO) NPs. Inorganically doped silica particles such as calcium-, iron-, manganese-, and zirconium-doped NPs, also have radically different hydrolytic stabilities. To conclude, the degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanomaterial in this large family according to the targeted applications and the required clearance kinetics.

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Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery

Cited by 15 publications

References 51 publications

Disulfide‐Bridged Organosilica Frameworks: Designed, Synthesis, Redox‐Triggered Biodegradation, and Nanobiomedical Applications

Disulfide‐Bridged Organosilica Frameworks: Designed, Synthesis, Redox‐Triggered Biodegradation, and Nanobiomedical Applications

Recent advances in cell imaging and cytotoxicity of intracellular stimuli-responsive nanomaterials

Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles

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