Biotechnology in the development of vaccines for animal parasites

Gamble, H. Ray; Zarlenga, Dante S.

doi:10.1016/0304-4017(86)90103-2

Cited by 10 publications

(4 citation statements)

References 48 publications

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“…Gamble (19856) suggested that a cocktail of adult antigens and ES antigens from muscle larvae could provide a potential vaccine for swine trichinosis. In a subsequent paper, Gamble & Zarlenga (1986) showed that a mixture of muscle larvae ES antigen and adult worm extract reduced the number of adult worms by 92%, newborn larvae by 7 1 % and muscle larvae by 96%, compared with controls.…”

Section: Trichinella Spiralismentioning

confidence: 97%

Excretory–secretory products of helminth parasites: effects on host immune responses

1988

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SUMMARYParasitic helminths excrete or secrete (ES) a variety of molecules into their mammalian hosts. The effects of these ES products on the host's immune responses are reviewed. Investigations into the source of antigenic or immunoregulatory ES products have identified the cuticular and tegumental surfaces of some nematodes and trematodes respectively as being important sources of ES products; other ES molecules are released through specialized excretory or secretory organs. It is proposed that the active shedding of surface antigens may serve as an important source of parasite antigens available to the immune system in a form in which they can be taken up and processed by antigen-presenting dendritic cells, macro-phages and certain B cells for presentation to T helper cells. The ES products of nematodes, trematodes and cestodes contribute to immune evasion strategies of the parasites through mechanisms including shedding of surface-bound ligands and cells, alteration of lymphocyte, macrophage and granulocyte functions and modulation of complement and other host inflammatory responses. Immunopathology may be induced by ES products as in the development of granulomas around entrapped schistosome eggs. In some host – parasite systems ES antigens may induce host-protective immune responses and this source of protective antigens has been utilized in the successful vaccination against helminth infections, particularly against infection with trichurid nematodes and the metacestode stage of cestode parasites. The use of ES antigens in immunodiagnosis of helminth infection is also briefly discussed.

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Section: Trichinella Spiralismentioning

confidence: 97%

Excretory–secretory products of helminth parasites: effects on host immune responses

1988

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“…Further, much of the knowledge gained in research into these areas of animal health may be directly applicable to control of similar diseases in humans. The applications of MAbs in parasitic diseases have been reviewed with respect to diagnosis (Gamble, 1984) and vaccine development (Gamble and Zarlenga, 1986;Gamble, 1987). However, two publications in these fields are noteworthy as they illustrate the relationships between MAb applications shown by solid fine arrows in Figure 1.…”

Section: Parasitesmentioning

confidence: 99%

Applications of Monoclonal Antibodies in Animal Health and Production

Raybould¹

1989

Animal Biotechnology

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“…Gastrointestinal nematodes are one of the most costly parasites in terms of production losses in ruminants and poultry (Gamble and Zarlenga;1986). Helminthiasis especially ascaridiasis is a concern for poultry industry globally as it leads to very high degree of pathogenicity.…”

Section: Introductionmentioning

confidence: 99%

Experimental Ascaridiasis Induced Immunosuppression in WLH Chicks: Biochemical Parameters

Tyagi¹,

Kumar²,

Panwar³

2021

The Scientific Temper

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This study was conducted to determine the effect of Ascaridia galli infection on immune system of White Leg Horn chicks. Impact on the immune system of the bird was studied in terms of biochemical parameters, i.e. blood sugar level, cholesterol level, urea level, acid phosphatase level, and alkaline phosphatase level in control group and in two other groups which were experimentally infected with 25 and 500 embryonated eggs of A. galli. Results obtained were statistically analyzed and presented in graphical form.

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Biotechnology in the development of vaccines for animal parasites

Cited by 10 publications

References 48 publications

Excretory–secretory products of helminth parasites: effects on host immune responses

Excretory–secretory products of helminth parasites: effects on host immune responses

Applications of Monoclonal Antibodies in Animal Health and Production

Experimental Ascaridiasis Induced Immunosuppression in WLH Chicks: Biochemical Parameters

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