Biotechnological Production of Natural Calorie Free Steviol Glycosides in Stevia rebaudiana: An Update on Current Scenario

Kazmi, Abeer; Khan, Mubarak Ali; Mohammad, Sher; Ali, Amir; Ali, Huma

doi:10.2174/2211550108666191210100751

Cited by 12 publications

(4 citation statements)

References 84 publications

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“…Nature has the best remedy for microbial infections. Plants which exist in nature contain various plant-specific secondary metabolites which can have robust bioactivities including anticancer, antiinflammatory, antiviral, antibacterial and antidiabetic functions 36,37…”

Section: Vaccines and Traditional Chinese Medicines (Tcms)mentioning

confidence: 99%

SARS-CoV-2 epidemic: causes and current situation, historical lessons, and strategical therapeutic interventions

Shereen

Kazmi

2020

Biomed. Res. Ther.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused an initial outbreak in China, now has 40 strains with infections in more than 200 countries worldwide, according to scientists. To date, 4,121,777 people have become infected and 280,868 people died as a result of corona virus disease of 2019 (COVID-19), with many patients still under critical condition. The SARS-CoV-2 is phylogenetically similar to SARS-like bat viruses and, thus, bats can be a key host for SARS-CoV-2. Many viruses have been transmitted to humans due to the consumption of wild birds and animals as a food source. The lack of vaccine, improper containment, and diagnostic strategies by various countries have converted COVID-19 into a global pandemic. The lockdown conditions in developing countries may produce economic crises. COVID-19 patients can suffer from mental distress, partly resulting from quarantine restrictions, and therefore, there is dire need for mental counseling. The combination of previously used broad-spectrum antibiotics, antiviral and anti-parasite agents, and interferon have reduced viral infection at higher and frequent doses. Many patients have been discharged after clinical recovery, though COVID-19 can still leave severe adverse effects on patients. The use of traditional Chinese medicines (TCMs) has led to recovery of 90% of COVID-19 patients in China. The current review article highlights the current situation, the major causes which have led to the COVID-19 pandemic, as well as strategical interventions to control the pandemic and cure infected patients.

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Section: Vaccines and Traditional Chinese Medicines (Tcms)mentioning

confidence: 99%

SARS-CoV-2 epidemic: causes and current situation, historical lessons, and strategical therapeutic interventions

Shereen

Kazmi

2020

Biomed. Res. Ther.

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“…Under sterile, regulated growth conditions, callus and tissuecultures can be used to generate SGs on a long-term basis. The variety of explants used, the category and concentration of plant growth hormones, and the in vitro growth environmental impact the formation of callus culture in stevia [37]. Callus tissues can maintain cell division capacity for longer periods of time, making them ideal as resources for bioactive compound generation, germplasm survival, and genetic manipulation, including gene editing and genetic engineering [38][39][40].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Regeneration of Stevia (Stevia rebaudiana Bertoni) and Evaluation of the Impacts of Growth Media Nutrients on the Biosynthesis of Steviol Glycosides (SGs)

et al. 2022

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A plant tissue culture protocol from stevia was optimized for the production of planting materials and the natural sweetener, rebaudioside A. The highest survivability (88.90% ± 5.55) of explants was achieved at 15 and 30 days after culture initiation (DACI) on Murashige and Skoog (MS) media by sterilization with 30% Clorox (5 min) and 10% Clorox (10 min), respectively. Supplementation of MS with 0.50 mg/L 2,4-Dichlorophenoxyacetic acid (2,4-D) and 0.10 mg/L zeatin produced 50% callus at 15 DACI while 1.50 mg/L 2,4-D and 0.10 mg/L zeatin at 30 DACI increased callus production to 76.67%. The highest shoot proliferation per callus was achieved with 10.00 mg/L 6-benzyl amino purine (BAP) in MS at 15 DACI (5.80) and 30 DACI (12.33). The longest shoots of 4.31 cm and 6.04 cm at 15 and 30 DACI, respectively, were produced using BAP (10.00 mg/L) and 1.00 mg/L naphthalene acetic acid (NAA). MS media (0.50 strength) induced 2.86 and 6.20 roots per shoot and produced 3.25 cm and 7.82 cm long roots at 15 and 30 DACI, respectively. Stevia grown on 0.25 MS accumulated the highest concentration of rebaudioside A (6.53%), which correlated with the expression level of its biosynthetic gene uridine-diphosphate-dependent (UDP)-glycosyltransferase (UGT76G1).

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“…It was named after M.S Bertoni, who first identified this plant. [4]. It is cultivated primarily in South America and Asia.…”

Section: Introductionmentioning

confidence: 99%

Study Of Some Anatomical Features Of Stevia Rebaudiana (Bertoni) Bertoni Grown In Iraq

AL-Taie¹

2021

JUAPS

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The leaves of Stevia rebaudiana, from Asteraceae family, are a source of steviol glycosides, which are utilized as a sweeter, more favorite addition. Among the most important anatomical results that were reached through the research and which distinguish the plant from an anatomical point of view are uniseriate-multicellular of non-glandular trichomes that are covered the epidermis of stem and leaves. Also, the vertical walls of the ordinary epidermis cells in the upper and lower epidermis that are heavily sinuous and the stomata scattered in both of it, the type of the stomata anomocytic. In addition, the mesophyll which differentiated into 2-3 layers of palisade cells under the upper epidermis and the spongy cells after it and the cross-section of midrib region of the leaf as crescent shape and the vascular bundle central, crescent shape. .

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Biotechnological Production of Natural Calorie Free Steviol Glycosides in Stevia rebaudiana: An Update on Current Scenario

Cited by 12 publications

References 84 publications

SARS-CoV-2 epidemic: causes and current situation, historical lessons, and strategical therapeutic interventions

SARS-CoV-2 epidemic: causes and current situation, historical lessons, and strategical therapeutic interventions

In Vitro Regeneration of Stevia (Stevia rebaudiana Bertoni) and Evaluation of the Impacts of Growth Media Nutrients on the Biosynthesis of Steviol Glycosides (SGs)

Study Of Some Anatomical Features Of Stevia Rebaudiana (Bertoni) Bertoni Grown In Iraq

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