Biotechnological approaches in Stevia rebaudiana and its Therapeutic Applications

Karimi, Roghaye

doi:10.19046/abp.v04i01.05

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…Apart from the sweetening glycosides, the leaves of stevia also contain essential amino acids, minerals such as phosphorus, potassium, sodium and calcium as well as phytochemicals such as flavonoids, alkaloids, hydroxycynnamic acids and triterpenes [2,3]. Karimi et al (2017) reported that the plant's various secondary metabolites have given it a range of therapeutic properties including anti-hypercglycaemic, anti-hypertensive, anti-oxidative, anti-microbial, anti-cariogenic and anti-carcinogenic (Table 1). It is thus referred as a sweetening plant with great pharmaceutical significance in comparison to other natural and synthetic sweeteners following its assorted chemical and nutritional constituents and their medicinal attributes [10].…”

Section: Stevia Rebaudianamentioning

confidence: 99%

“…butenyl-4-diphosphate synthase (HDS) and 1-hydroxy-2-methyl-2(E)-butenyl-4diphosphate reductase (HDR) [18,20]. technology [21]. These methods are robust, widely applicable, fast, efficient and costeffective [44].…”

Section: Biosynthesis Of Steviol Glycosidesmentioning

confidence: 99%

“…A vast range of molecular marker technologies have also been used to develop functional molecular markers for diversity characterization and genetic improvement of the plant [18]. Apart from that molecular breeding approaches also have been implemented to increase the dry weight of stevia leaves thus increasing the sweetening compounds yields [21]. These biotechnological approaches not only have significant role in the improvement of SGs production in stevia, but can be extended in improving the plant's overall agronomy, biochemistry, evolutionary studies, genome mapping, morphology and physiology as well.…”

Section: Biosynthesis Of Steviol Glycosidesmentioning

confidence: 99%

“…technology [21]. These methods are robust, widely applicable, fast, efficient and costeffective [44].…”

Section: Biotechnologıcal Approaches For Stevıol Glycosıdes Improvement In Stevıa Rebaudıanamentioning

confidence: 99%

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A Review of Approaches in Steviol Glycosides Synthesis

Samsulrizal

Zainuddin

Noh

et al. 2019

International Journal of Life Sciences and Biotechnology

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Stevia rebaudiana (Bertoni) is a commercially important plant worldwide. The leaves of Stevia rebaudiana contain steviol glycosides which are non-caloric, high-potency sweeteners. They are suitable for substituting sucrose and other artificial sweetening agents. Stevia rebaudiana also has many different therapeutic uses, with antidiabetic, anti-cariogenic, antimicrobial, anticancer and antioxidative properties. Rebaudioside A and stevioside are the major glycosides produced in its leaves. However, development of new varieties of Stevia rebaudiana with a greater content of rebaudioside A and decreased content of stevioside is the main concern lately. This is due to rebaudioside A having a more desirable sweet flavour taste than stevioside which possesses bitter aftertaste. In respect to that many biotechnological approaches are being used for the industrial improvement and manipulation of steviol glycosides content of Stevia rebaudiana. Transcriptome profiling has emerged as a useful tool to identify target genes involved in the steviol glycosides biosynthesis pathway. Understanding the mechanism and biosynthesis pathway of these compounds has further helped to improve the glycosides profile by up-regulating and down-regulating the desired genes. The aim of this paper is to describe the latest development in the transcriptome profiling in Stevia rebaudiana as well as to discuss the methods used in this endeavour.

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Section: Stevia Rebaudianamentioning

confidence: 99%

Section: Biosynthesis Of Steviol Glycosidesmentioning

confidence: 99%

Section: Biosynthesis Of Steviol Glycosidesmentioning

confidence: 99%

“…technology [21]. These methods are robust, widely applicable, fast, efficient and costeffective [44].…”

Section: Biotechnologıcal Approaches For Stevıol Glycosıdes Improvement In Stevıa Rebaudıanamentioning

confidence: 99%

See 2 more Smart Citations

A Review of Approaches in Steviol Glycosides Synthesis

Samsulrizal

Zainuddin

Noh

et al. 2019

International Journal of Life Sciences and Biotechnology

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A review on current conventional and biotechnical approaches to enhance biosynthesis of steviol glycosides in Stevia rebaudiana

Basharat

Huang

Gong

et al. 2021

Chinese Journal of Chemical Engineering

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Callus induction and somatic embryogenesis in Stevia rebaudiana Bertoni as a medicinal plant

Keshvari

Najaphy

Kahrizi

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Stevia rebaudiana (Bert.) from Asteraceae family is a useful medicinal plant that prevents and cures diabetes, blood pressure, weight gain and tooth decay. Due to self-incompatibility in stevia, somatic embryo investigation for artificial seed production is valuable in this plant. In order to evaluate the callus induction characteristics in stevia, a factorial experiment was laid out based on a completely randomized design with three replications. The factors included ten hormone combinations and control, two kinds of media (MS and B5) and two types of explants (leaf and internode). Callus induction characters including the percentage of callus formation, days to callus induction, fresh and dry callus weight were recorded. Analysis of variance showed significant differences (p<0.01) among hormone combinations, media and explant types as well as their interactions. The best treatment for callus induction with minimum time to callus formation was 1 mg/l NAA+1 mg/l BAP. The highest fresh and dry callus weight were obtained on B5 medium supplemented by 1 mg/l 2,4-D+1 mg/l BAP (in leaf explant) and 0.25 mg/l 2,4-D+ 0.1 mg/l BAP (in internode explant). These results can be used in suspension culture. To induce somatic embryogenesis in suspension culture, six hormone treatments were investigated. The highest somatic embryogenesis percentage was obtained in MS medium supplemented by 2 mg/l 2,4-D+ 0.5 mg/l NAA+0.5 mg/l BAP.

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Biotechnological approaches in Stevia rebaudiana and its Therapeutic Applications

Cited by 3 publications

References 52 publications

A Review of Approaches in Steviol Glycosides Synthesis

A Review of Approaches in Steviol Glycosides Synthesis

A review on current conventional and biotechnical approaches to enhance biosynthesis of steviol glycosides in Stevia rebaudiana

Callus induction and somatic embryogenesis in Stevia rebaudiana Bertoni as a medicinal plant

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