Biosynthetic Study of Amphidinolide W.

The Biosynthesis of Polyketide Metabolites by Dinoflagellates

“…Stable isotope incorporation experiments have been performed on amphidinolide B, C, H, J, T1, W, X, and Y (Fig. 5) (Kobayashi et al, 1995Kubota et al, 2001b;Sato et al, 2000;Tsuda et al, 2001Tsuda et al, ,2002Tsuda et al, ,2003a. These studies have revealed that all carbons of the amphidinolides, including pendent methyl groups, which are more typically derived from S-adenosylmethionine (SAM) or propionate incorporation, are derived from acetate.…”

Biosynthetic Study of Amphidinin A and Amphidinolide P

“…[2][3][4][5][6][7] The carbon skeletons of dinoflagellate polyketides are unique and unavailable from other organisms, since they might be generated by unexplained one-carbon extension machinery in addition to the ordinary polyketide biosynthesis. 8) In our continuing biosynthetic study of dinoflagellate polyketides, [9][10][11][12][13][14][15][16] we have recently re-isolated amphidinin A (1) 17,18) and amphidinolide P (2) 19,20) from the cultured marine dinoflagellate Amphidinium sp. (2012-7-4A strain) which were isolated from an acoel flatworm Amphiscolops sp.…”

(3S)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbutan-1-ol—A universal building block for the synthesis of principal fragments of amphidinolides G and H

“…All solvents were dried according to standard procedures and distilled before use. (14). A solution of 1.47 g (7.8 mmol) of alcohol 9 in 10 mL of anhydrous methylene chloride was added in one portion to a suspension of 4.28 g (11.7 mmol) of pyridinium dichromate (PDC) in 25 mL of anhydrous methylene chloride, and the mixture was stirred for 10 h until the reaction was complete.…”

“…They have occupied the leading position in the search for new drugs and base model structures in life sciences for the determination of mechanisms of functioning of biosystems [2,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23].…”